Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

Abstract: An apparatus includes an electroactive polymer member and a first electric terminal and a second electric terminal. The electroactive polymer member has a free portion configured to change position relative to a fixed portion in response to an external stimulus corresponding to at least one of a flow parameter or a fluid parameter. The first electric terminal and the second electric terminal are coupled to the electroactive polymer member. The first electric terminal and the second electric terminal provide an electrical signal in response to the change.

Abstract: An apparatus includes an electroactive polymer member and a first electric terminal and a second electric terminal. The electroactive polymer member has a free portion configured to change position relative to a fixed portion in response to an external stimulus corresponding to at least one of a flow parameter or a fluid parameter. The first electric terminal and the second electric terminal are coupled to the electroactive polymer member. The first electric terminal and the second electric terminal provide an electrical signal in response to the change.

Abstract: In one embodiment, the invention is a moment-based characterization waveform for static timing analysis. One embodiment of a method for mapping a timing waveform associated with a gate of an integrated circuit to a characterization waveform includes using a processor to perform steps including: computing one or more moments of the timing waveform and defining the characterization waveform in accordance with the moments.

Abstract: In one embodiment, the invention is a moment-based characterization waveform for static timing analysis. One embodiment of a method for mapping a timing waveform associated with a gate of an integrated circuit to a characterization waveform includes using a processor to perform steps including: computing one or more moments of the timing waveform and defining the characterization waveform in accordance with the moments.

Abstract: A method for controlling the start of combustion and peak burn rate of an internal combustion engine system on a cycle-to-cycle basis including multiple direct fuel injectors, multiple indirect fuel injectors, and multiple liquid fuels. The actual start of combustion and actual peak burn rate are calculated using in-cylinder pressure or ionization. A predetermined start of combustion and a predetermined peak burn rate are selected. The start of combustion and peak burn rate control algorithm includes controlling a fuel ratio, an injection ratio, and a residual gas recirculation ratio. A predetermined fuel ratio, a predetermined injection ratio, and a predetermined residual gas recirculation are calculated by combining feed forward ratios and closed loop control ratios corresponding to the three ratios. The predetermined ratios are employed so that the system achieves the predetermined start of combustion and predetermined peak burn rate.

Abstract: A method and apparatus for collecting information about an event in which a user accesses the Internet through the system of a first Internet Service Provider with whom the user does not have an account. The apparatus includes a first server that creates a record of the user's Internet usage and sends the record to a second server. The second server collects records from a plurality of Internet Service Providers and forwards the records to a third server on a regular basis. The third server processes the data in the plurality of records and generates a report showing how much money the first Internet Service Provider is owed for allowing the user to access the Internet through the system of the first Internet Service Provider.

Abstract: A method and apparatus for collecting information about an event in which a user accesses the Internet through the system of a first Internet Service Provider with whom the user does not have an account. The apparatus includes a first server that creates a record of the user's Internet usage and sends the record to a second server. The second server collects records from a plurality of Internet Service Providers and forwards the records to a third server on a regular basis. The third server processes the data in the plurality of records and generates a report showing how much money the first Internet Service Provider is owed for allowing the user to access the Internet through the system of the first Internet Service Provider.

Abstract: A fuel injection system for an internal combustion engine is disclosed, the fuel injection system including a plurality of injectors, wherein each of the injectors is adapted to inject at least one of an alternative fuel and a fossil fuel over a full range of operating conditions of the engine.

Abstract: A spanner comprises a box end that has an inner periphery consisting of a number of wall faces to define a first polygonal receiving space. Each wall face includes a groove defined therein. The grooves of the wall faces together define a second polygonal receiving space. At least one of the grooves includes a closed first end and an open second end.

Abstract: A nozzle for a low pressure fuel injection that improves the control and size of the spray angle, as well as enhances the atomization of the fuel delivered to the cylinder for an engine, at relatively low pressures. The nozzle includes a metering plate having inner and outer exit cavities in rings spaced circumferentially about a center exit cavity.

Abstract: A fuel injection system for an internal combustion engine is disclosed, the fuel injection system including a plurality of injectors, wherein each of the injectors is adapted to inject at least one of an alternative fuel and a fossil fuel over a full range of operating conditions of the engine.

Abstract: A fuel injector having a nozzle with depressions for increasing fluid turbulence and preventing deposit build up within the injector to increase performance, longevity and fuel economy.

Abstract: A low pressure fuel injector capable of atomizing fuel at relatively low pressure is configured to have reduced hydraulic resistance. Reduction in the hydraulic resistance minimizes the pressure drop within the fuel injector and thereby improves atomization of the fuel for improved fuel economy and performance, and decreased emissions.

Abstract: A nozzle for a low pressure fuel injection that improves the control and size of the spray angle, as well as enhances the atomization of the fuel delivered to the cylinder for an engine.

Abstract: A nozzle for a low pressure fuel injection that improves the control and size of the spray angle, as well as enhances the atomization of the fuel delivered to the cylinder for an engine.

Abstract: A nozzle for a low pressure fuel injector that improves the control and size of the spray angle, as well as enhances the atomization of the fuel delivered to a cylinder of an engine.

Abstract: A spanner comprises a box end that has an inner periphery consisting of a number of wall faces to define a first polygonal receiving space. Each wall face includes a groove defined therein. The grooves of the wall faces together define a second polygonal receiving space. At least one of the grooves includes a closed first end and an open second end.

Abstract: A spanner comprises a box end that has an inner periphery consisting of a number of wall faces to define a first polygonal receiving space. Each wall face includes a groove defined therein. The grooves of the wall faces together define a second polygonal receiving space. At least one of the grooves includes a closed first end and an open second end.

Abstract: A method and apparatus for collecting information about an event in which a user accesses the Internet through the system of a first Internet Service Provider with whom the user does not have an account. The apparatus includes a first server that creates a record of the user's Internet usage and sends the record to a second server. The second server collects records from a plurality of Internet Service Providers and forwards the records to a third server on a regular basis. The third server processes the data in the plurality of records and generates a report showing how much money the first Internet Service Provider is owed for allowing the user to access the Internet through the system of the first Internet Service Provider.