Abstract: The present invention relates to methods for the detection of nucleic acids of defined sequence and kits and devices for use in said methods. The methods employ restriction enzymes. polymerase and oligonucleotide primers to produce an amplification product in the presence of a target nucleic acid. which is contacted with oligonucleotide probes to produce a detector product.

Abstract: The present invention relates to methods for the detection of nucleic acids of defined sequence and kits and devices for use in said methods. The methods employ restriction enzymes, polymerase and oligonucleotide primers to produce an amplification product in the presence of a target nucleic acid, which is contacted with oligonucleotide probes to produce a detector product.

Abstract: The invention relates to parathyroid hormone (PTH) variants and pharmaceutical compositions comprising same. The invention further relates to PTH compositions with improved serum half-life and peak-trough ratios, and methods of controlling serum calcium levels with the PTH variants and compositions of the invention. The invention further relates to methods of treating hypoparathyroidism and/or hypocalcemia due to hypoparathyroidism with the PTH variants and compositions of the invention.

Abstract: Rechargeable electrochemical battery cells are disclosed. In particular, are disclosed discharge state assembled rechargeable electrochemical cells, which, when in discharged state, comprises an electrically conductive anodic current collector and a cathode that comprises metallic material as an active material.

Abstract: The present invention relates to methods for the detection of nucleic acids of defined sequence and kits and devices for use in said methods. The methods employ restriction enzymes, polymerase and oligonucleotide primers to produce an amplification product in the presence of a target nucleic acid, which is contacted with oligonucleotide probes to produce a detector product.

Abstract: Provided herein are GLP-1 receptor modulator compounds, pharmaceutical compositions, methods of their preparation, and methods of their use in treatment, and/or diagnosis.

Abstract: The present invention relates to methods for the detection of nucleic acids of defined sequence and kits and devices for use in said methods. The methods employ restriction enzymes, polymerase and oligonucleotide primers to produce an amplification product in the presence of a target nucleic acid, which is contacted with oligonucleotide probes to produce a detector product.

Abstract: A modular stator for a torque converter includes a stator hub, an outer ring, and a plurality of blades extending radially between the stator hub and the outer ring. Each blade is releasably securable to the stator hub in at least two different orientations. A blade angle of the plurality of blades can be predetermined by selecting one of the at least two orientations. A lock member secures each blade at the selected orientation.

Abstract: An asynchronous finite state machine circuit comprising state circuitry configured to be in one of a plurality of states, and transition between states, wherein the asynchronous finite state machine is configured to detect that a current state is stable before the state circuitry can transition to a next state.

Abstract: A method of making a paper product can comprise making one or more sheets at least by, for each of the sheet(s), forming a web from one or more furnishes that comprise fibers dispersed in water. The fibers of the furnish(es) can comprise a plurality of first fibers that are hardwood fibers and a plurality of second fibers that include softwood fibers and surface enhanced pulp fibers (SEPF), the SEPF having a length weighted average fiber length of at least 0.20 mm. The method can comprise at least partially dewatering the web to form the sheet. The sheet(s) can be laminated and/or embossed such that a total dry tensile strength of the paper product is less than or equal to 90% of the sum of the total dry tensile strength(s) of the sheet(s).

Abstract: The present application relates to an electrochemical cell comprising a nitrile-based solvent based electrolyte, wherein the electrochemical cell includes an electrolyte salt that comprises NaClO4, and the electrolyte salt has a maximum electrolyte conductivity at a discharge state Molar concentration greater than 1.

Abstract: Paper products can comprise a first plurality of fibers that are hardwood fibers and a second plurality of fibers that include softwood fibers and surface enhanced pulp fibers (SEPF). The paper product can include one or more first fiber layers that comprise the first fibers, at least one of the first fiber layer(s) defining one of opposing upper and lower surfaces of the paper product, and one or more second fiber layers that comprise the second fibers. When a tissue, by weight, between 50% and 80% of the tissue's fibers can be the first fibers and at least 20% of the tissue's fibers can be the second fibers. The tissue's basis weight can be less than or equal to 21 gsm per ply.

Abstract: Provided herein are GLP-1 receptor modulator compounds, pharmaceutical compositions, methods of their preparation, and methods of their use in treatment, and/or diagnosis.

Abstract: The invention relates to parathyroid hormone (PTH) variants and pharmaceutical compositions comprising same. The invention further relates to PTH compositions with improved serum half-life and peak-trough ratios, and methods of controlling serum calcium levels with the PTH variants and compositions of the invention. The invention further relates to methods of treating hypoparathyroidism and/or hypocalcemia due to hypoparathyroidism with the PTH variants and compositions of the invention.

Abstract: Components and structures for a rechargeable electrochemical cell and an electrochemical cell having an S02 solvent based electrolyte comprising any of said components and structures are provided. The cathode (2) may comprise one or more elemental transition metals and/or one or more partially oxidized transition metals. The S02 solvent based electrolyte (3) may comprise halide-containing salt additive as an SEI-forming additive. The anode current collector (5) may comprise a carbon coated metal, an alloy of two or more metals or a carbon coated alloy of two or more metals. The electrochemical cell may comprise excess non-dissolved/solid alkali halides. The components, structures and cell may bay used in a device.

Abstract: Disclosed herein are several embodiments of a negative pressure system and methods of using the same in the treatment of wounds. Some embodiments are directed to a system that utilizes a wound dressing with at least three layers. These embodiments are directed toward improved distribution of negative pressure to a wound and periwound site surrounding the wound. Some embodiments are directed to a fixation strip for sealing a wound dressing to a wound and periwound site. The fixation strip can comprise multiple layers including an adhering layer, a wound sealing layer and at least one protective liner.

Abstract: A method of calculating in vivo force on an anterior cruciate ligament (ACL) by measuring one or more biomechanical properties during a biomechanical screening task to obtain one or more biomechanical datum from the measured one or more biomechanical properties, and calculating a total load on an anterior cruciate ligament from an ACL force model using the one or more biomechanical datum as inputs to the ACL force model. The ACL force model is defined by FACL=FACLsag+FACLfront+FACLtrans+?jCTj, wherein FACL is the total force on the ACL, FACLsag is the force on the ACL in a sagittal plane, FACLfront is the force on the ACL in the frontal plane, FACLtrans is the force on the ACL in the transverse plane, and CTj is the ACL force interaction relationships among the sagittal-frontal (SF), sagittal-transverse (ST), and frontal-transverse (FT) planes, where j=SF, ST, FT.

Abstract: A system includes a memory, a processor in communication with the memory, and a compiler. The compiler is configured to initialize at least one class for an application at compilation time, start a framework at compilation time, and serialize a framework container of the framework into a native image at compilation time. The processor is configured to run the native image to start the application.

Abstract: Provided herein are GLP-1 receptor modulator compounds, pharmaceutical compositions, methods of their preparation, and methods of their use in treatment, and/or diagnosis.

Abstract: The present invention relates to methods for the detection of nucleic acids of defined sequence and kits for use in said methods. The methods employ nicking agent(s), polymerase and oligonucleotide probes to produce probe fragments in the presence of a target nucleic acid.