Abstract: The invention relates to parathyroid hormone (PTH) variants and pharmaceutical compositions comprising same. The invention further relates to PTH compositions with improved serum half-life and peak-trough ratios, and methods of controlling serum calcium levels with the PTH variants and compositions of the invention. The invention further relates to methods of treating hypoparathyroidism and/or hypocalcemia due to hypoparathyroidism with the PTH variants and compositions of the invention.

Abstract: Rechargeable electrochemical battery cells are disclosed. In particular, are disclosed discharge state assembled rechargeable electrochemical cells, which, when in discharged state, comprises an electrically conductive anodic current collector and a cathode that comprises metallic material as an active material.

Abstract: The present invention relates to methods for the detection of nucleic acids of defined sequence and kits and devices for use in said methods. The methods employ restriction enzymes, polymerase and oligonucleotide primers to produce an amplification product in the presence of a target nucleic acid, which is contacted with oligonucleotide probes to produce a detector product.

Abstract: Provided herein are GLP-1 receptor modulator compounds, pharmaceutical compositions, methods of their preparation, and methods of their use in treatment, and/or diagnosis.

Abstract: An electrical receptacle, that receives an electrical plug having a male terminal or a female terminal, includes the other of the male terminal or female terminal and a latch that, responsive to movement of the electrical plug toward the electrical receptacle resulting in movement of the male terminal into the female terminal, rides along serrations of the serrated insert such that the latch and one of the serrations cooperate to resist disengagement of the electrical plug from the electrical receptacle.

Abstract: The present invention relates to methods for the detection of nucleic acids of defined sequence and kits and devices for use in said methods. The methods employ restriction enzymes, polymerase and oligonucleotide primers to produce an amplification product in the presence of a target nucleic acid, which is contacted with oligonucleotide probes to produce a detector product.

Abstract: A method and apparatus therefor comprises: receiving an image data and a power metadata, wherein the power metadata includes information relating to a power consumption or an expected power consumption; determining, based on the power metadata, an amount and a duration of a drive modification that may be performed by a target display in response to the power consumption or the expected power consumption; and performing a power management of the target display based on the power metadata to modify a driving of at least one light-emitting element associated with the target display relative to a manufacturer-determined threshold, based on a result of the determining, wherein the power metadata includes at least one of a temporal luminance energy metadata, a spatial luminance energy metadata, a spatial temporal fluctuation metadata, or combinations thereof.

Abstract: A modular stator for a torque converter includes a stator hub, an outer ring, and a plurality of blades extending radially between the stator hub and the outer ring. Each blade is releasably securable to the stator hub in at least two different orientations. A blade angle of the plurality of blades can be predetermined by selecting one of the at least two orientations. A lock member secures each blade at the selected orientation.

Abstract: A system receives a vehicle transport instruction for transporting a vehicle. The system instructs display of an indicator related to the transport instruction, using a first vehicle output. Further, the system determines whether a vehicle is in a state designated for alert notification based on at least a transportation error detected by the vehicle and changes at least one of the first vehicle output or a second vehicle output to indicate the transportation error responsive to detection of the transportation error by the vehicle.

Abstract: An asynchronous finite state machine circuit comprising state circuitry configured to be in one of a plurality of states, and transition between states, wherein the asynchronous finite state machine is configured to detect that a current state is stable before the state circuitry can transition to a next state.

Abstract: A method of making a paper product can comprise making one or more sheets at least by, for each of the sheet(s), forming a web from one or more furnishes that comprise fibers dispersed in water. The fibers of the furnish(es) can comprise a plurality of first fibers that are hardwood fibers and a plurality of second fibers that include softwood fibers and surface enhanced pulp fibers (SEPF), the SEPF having a length weighted average fiber length of at least 0.20 mm. The method can comprise at least partially dewatering the web to form the sheet. The sheet(s) can be laminated and/or embossed such that a total dry tensile strength of the paper product is less than or equal to 90% of the sum of the total dry tensile strength(s) of the sheet(s).

Abstract: A smart hose system includes a hose and a clamp monitor secured to the hose and in proximity to a portion of the hose at which a clamp is to be secured. The clamp monitor is configured to responsively interact with the clamp and includes a signal generator configured to provide a first response to an inquiry signal with the clamp being in a first state and provide a second response with the clamp being in a second state.

Abstract: The present application relates to an electrochemical cell comprising a nitrile-based solvent based electrolyte, wherein the electrochemical cell includes an electrolyte salt that comprises NaClO4, and the electrolyte salt has a maximum electrolyte conductivity at a discharge state Molar concentration greater than 1.

Abstract: Paper products can comprise a first plurality of fibers that are hardwood fibers and a second plurality of fibers that include softwood fibers and surface enhanced pulp fibers (SEPF). The paper product can include one or more first fiber layers that comprise the first fibers, at least one of the first fiber layer(s) defining one of opposing upper and lower surfaces of the paper product, and one or more second fiber layers that comprise the second fibers. When a tissue, by weight, between 50% and 80% of the tissue's fibers can be the first fibers and at least 20% of the tissue's fibers can be the second fibers. The tissue's basis weight can be less than or equal to 21 gsm per ply.

Abstract: The present invention relates to a novel chemical compound for use in the treatment of cancer, to compositions containing said compound, methods of manufacture and combinations with other therapeutic agents.

Abstract: Provided herein are GLP-1 receptor modulator compounds, pharmaceutical compositions, methods of their preparation, and methods of their use in treatment, and/or diagnosis.

Abstract: A system receives a vehicle transport instruction for transporting a vehicle. The system instructs display of an indicator related to the transport instruction, using a first vehicle output. Further, the system determines whether a vehicle is in a state designated for alert notification based on at least a transportation error detected by the vehicle and changes at least one of the first vehicle output or a second vehicle output to indicate the transportation error responsive to detection of the transportation error by the vehicle.

Abstract: The invention is directed towards a battery. The battery includes a cathode, an anode, a separator between the cathode and the anode, and an electrolyte. The cathode includes a conductive additive and an electrochemically active cathode material. The electrochemically active cathode material includes a beta-delithiated layered nickel oxide. The beta-delithiated layered nickel oxide has a chemical formula. The chemical formula is LixAyNi1+a?zMzO2·nH2O where x is from about 0.02 to about 0.20; y is from about 0.03 to about 0.20; a is from about 0 to about 0.2; z is from about 0 to about 0.2; and n is from about 0 to about 1. Within the chemical formula, A is an alkali metal. The alkali metal includes potassium, rubidium, cesium, and any combination thereof. Within the chemical formula, M comprises an alkaline earth metal, a transition metal, a non-transition metal, and any combination thereof. The anode includes an electrochemically active anode material.

Abstract: The present invention relates to a novel chemical compound for use in the treatment of cancer, to compositions containing said compound, methods of manufacture and combinations with other therapeutic agents.