Abstract: An aqueous pharmaceutical composition comprising a lipophilic oligosaccharide antibiotic salt, e.g., the N-methylglucamine salt of the everninomicin-type antibiotic of Formula III together with a binding agent such as human serum albumin or recombinant human albumin and a tonicity agent such as mannitol, is disclosed.

Abstract: Pharmaceutically acceptable compositions of matter comprising a lipophilic oligosaccharide antibiotic, e.g., the everninomicin-type antibiotic of Formula III, at least a stoichiometric amount of a base, e.g., N-methylglucamine, an amount of, e.g., hydroxypropyl-.beta.-cyclodextrin, and optionally a pharmaceutically acceptable non-ionic surfactant, e.g., Tween-80, pharmaceutical compositions containing such compositions of matter, methods of treating and preventing susceptible bacterial infections in animals especially human beings as well as a method of preventing adverse reaction syndrome while simultaneously delivering an antiinfective amount of a lipophilic oligosaccharide antibiotic such as that of Formula III to said animals as well as the use of the compositions of matter for the preparation of a medicament for such treating or preventing are disclosed.

Abstract: The present invention relates to topical compositions and methods of use utilizing compounds of the formula ##STR1## wherein X is oxygen or sulfur;W is a bridge group of the formulae ##STR2## wherein R is hydrogen alkyl of 1 to 7 carbon atoms, cycloalkyl of 4-8 carbon atoms, cycloalkenyl of 5-8 carbon atoms, polyfluoroalkyl of 1-4 carbon atoms, phenyl, benzyl or alkoxycarbonylmethyl; R.sub.1 is hydrogen or alkyl of 1-7 carbon atoms; m is 0-2; n is 1-4; with the proviso that m+n is 3-5; andA.sub.1, A.sub.2, A.sub.3, A.sub.4, B.sub.1, B.sub.2, B.sub.3, and B.sub.4 are independently selected from the group consisting of hydrogen, methyl, cyano, nitro, polyfluoroalkyl of 1-3 carbon atoms, chloro, bromo, fluoro and alkylthio, with the proviso that 2-5 of there are hydrogen of which at least one of A.sub.1, A.sub.2, A.sub.3 and A.sub.4 and at least one of B.sub.1, B.sub.2, B.sub.3 and B.sub.4 is hydrogen.