Abstract: The present invention features assays for co-culturing primary cells while maintaining key biological activities specific to the primary cells. The invention is based, at least in part, on the discovery that compositions and methods for primary cells in a high-throughput co-culture platform, image analysis for distinguishing cells in co-cultures and assays that are suitable for screening of agents in epithelial cells, such as hepatocytes.

Abstract: An apparatus includes a laser system that includes a first fiber having an output end and situated to propagate a first laser beam with a first beam parameter product (bpp) and a second fiber having an input end spliced to the output end of the first fiber at a fiber splice so as to receive the first laser beam and to form a second laser beam having a second bpp that is greater than the first bpp, wherein the output end of the first fiber and the input end of the second fiber are spliced at a tilt angle so as to increase the first bpp to the second bpp.

Abstract: An embodiment of the present invention is directed to an automated validation tool for migration from a source system to a target system. The system comprises: a memory component; an interactive interface that receives one or more user inputs; and a validation engine comprising a processor, coupled to the memory component and the interactive interface, the validation engine configured to perform the steps comprising: initiating a migration process from a source system to a target system; identifying a source identifier of the source system and a target identifier of the target system; performing validation of the migration process; comparing project configuration data of the source system and the target system; comparing project data of the source system and the target system; and providing, via the interactive interface, validation results.

Abstract: The present invention features assays for co-culturing primary cells while maintaining key biological activities specific to the primary cells. The invention is based, at least in part, on the discovery that compositions and methods for primary cells in a high-throughput co-culture platform, image analysis for distinguishing cells in co-cultures and assays that are suitable for screening of agents in epithelial cells, such as hepatocytes.

Abstract: An apparatus includes a laser system that includes a first fiber having an output end and situated to propagate a first laser beam with a first beam parameter product (bpp) and a second fiber having an input end spliced to the output end of the first fiber at a fiber splice so as to receive the first laser beam and to form a second laser beam having a second bpp that is greater than the first bpp, wherein the output end of the first fiber and the input end of the second fiber are spliced at a tilt angle so as to increase the first bpp to the second bpp.

Abstract: The present invention features assays for co-culturing primary cells while maintaining key biological activities specific to the primary cells. The invention is based, at least in part, on the discovery that compositions and methods for primary cells in a high-throughput co-culture platform, image analysis for distinguishing cells in co-cultures and assays that are suitable for screening of agents in epithelial cells, such as hepatocytes.

Abstract: An apparatus includes a laser system that includes a first fiber having an output end and situated to propagate a first laser beam with a first beam parameter product (bpp) and a second fiber having an input end spliced to the output end of the first fiber at a fiber splice so as to receive the first laser beam and to form a second laser beam having a second bpp that is greater than the first bpp, wherein the output end of the first fiber and the input end of the second fiber are spliced at a tilt angle so as to increase the first bpp to the second bpp.

Abstract: An embodiment of the present invention is directed to an automated validation tool for migration from a source system to a target system. The system comprises: a memory component; an interactive interface that receives one or more user inputs; and a validation engine comprising a processor, coupled to the memory component and the interactive interface, the validation engine configured to perform the steps comprising: initiating a migration process from a source system to a target system; identifying a source identifier of the source system and a target identifier of the target system; performing validation of the migration process; comparing project configuration data of the source system and the target system; comparing project data of the source system and the target system; and providing, via the interactive interface, validation results.

Abstract: Systems and methods utilize a distributed server network to allow for the optimization of the upload of a data stream from a computing device. Performance metrics are estimated for different network paths from the computing device to a variety of entry servers in the distributed server network. Based on the estimated performance metrics, one or more entry servers are then selected to receive the data stream from the computing device. As a result, the systems and methods described herein allow for high quality upload performance which addresses the first mile vulnerability issues of the data stream. The distributed server network can then transmit copies of the data stream in real-time to other computing devices.

Abstract: Systems and methods described herein utilize a distributed server network to allow for the real-time distribution of copies of a data stream uploaded from a computing device. The uploaded data stream corresponds to an environment surrounding a user (exam taker) of the computing device during execution of a testing routine for an examination. Providing copies of the data stream in real-time allows proctors as well as other test assessment authorities to ‘peek in’ on the exam taker's environment surrounding the exam. As a result, the environment surrounding the exam taker can be monitored in real-time to determine whether any visual or audio activity in the environment constitutes activity not in accordance with the exam protocol. Following an affirmative determination that the exam taker violated an exam taking protocol, the proctor or other test assessment authority can then make a final or early decision regarding disciplinary action.

Abstract: Systems and methods utilize a distributed server network to allow for the optimization of the upload of a data stream from a computing device. Performance metrics are estimated for different network paths from the computing device to a variety of entry servers in the distributed server network. Based on the estimated performance metrics, one or more entry servers are then selected to receive the data stream from the computing device. As a result, the systems and methods described herein allow for high quality upload performance which addresses the first mile vulnerability issues of the data stream. The distributed server network can then transmit copies of the data stream in real-time to other computing devices.

Abstract: Systems and methods utilize a distributed server network to allow for the optimization of the upload of a data stream from a computing device. Performance metrics are estimated for different network paths from the computing device to a variety of entry servers in the distributed server network. Based on the estimated performance metrics, one or more entry servers are then selected to receive the data stream from the computing device. As a result, the systems and methods described herein allow for high quality upload performance which addresses the first mile vulnerability issues of the data stream. The distributed server network can then transmit copies of the data stream in real-time to other computing devices.

Abstract: An apparatus includes a laser system that includes a first fiber having an output end and situated to propagate a first laser beam with a first beam parameter product (bpp) and a second fiber having an input end spliced to the output end of the first fiber at a fiber splice so as to receive the first laser beam and to form a second laser beam having a second bpp that is greater than the first bpp, wherein the output end of the first fiber and the input end of the second fiber are spliced at a tilt angle so as to increase the first bpp to the second bpp.

Abstract: An improved loudspeaker system includes an asymmetrical array of dissimilar drivers, namely a first driver and a second complementary driver configured in an array and driven in parallel so that the measured on-axis frequency response and the output power (SPL) is improved as compared to a symmetrical array (with similar or matched midrange or mid-bass drivers), while retaining a flat tonal balance. This speaker system and method for voicing was discovered to provide lower distortion, improved frequency response and greater clarity as compared to the prior art or traditional (e.g., MTM) loudspeaker configurations.

Abstract: Systems and methods described herein utilize a distributed server network to allow for the real-time distribution of copies of a data stream uploaded from a computing device. The uploaded data stream corresponds to an environment surrounding a user (exam taker) of the computing device during execution of a testing routine for an examination. Providing copies of the data stream in real-time allows proctors as well as other test assessment authorities to ‘peek in’ on the exam taker's environment surrounding the exam. As a result, the environment surrounding the exam taker can be monitored in real-time to determine whether any visual or audio activity in the environment constitutes activity not in accordance with the exam protocol. Following an affirmative determination that the exam taker violated an exam taking protocol, the proctor or other test assessment authority can then make a final or early decision regarding disciplinary action.

Abstract: Systems and methods described herein utilize a distributed server network to allow for the real-time distribution of copies of a data stream uploaded from a computing device. The uploaded data stream corresponds to an environment surrounding a user (exam taker) of the computing device during execution of a testing routine for an examination. Providing copies of the data stream in real-time allows proctors as well as other test assessment authorities to ‘peek in’on the exam taker's environment during the exam. As a result, the environment surrounding the exam taker can be monitored in real-time to determine whether any visual or audio activity in the environment constitutes activity not in accordance with the exam protocol. Following an affirmative determination that the exam taker violated an exam taking protocol, a proctor or other test assessment authority can then make a final or early decision regarding disciplinary action.

Abstract: High power fiber lasers include large or very large mode area active fibers. Mode preserving pump combiners are situated to counter-pump the active fiber using one or more pump sources. The mode preserving pump combiners preserve single mode propagation in a signal fiber, and such combiners can be identified based on optical spectra, beam quality, or temporal response. Active fibers can also be included in a pump combiner so that the active fiber is splice free from an input end that receives a seed pulse to an output end. Peak powers of over 100 kW can be obtained.

Abstract: Systems and methods utilize a distributed server network to allow for the optimization of the upload of a data stream from a computing device. Performance metrics are estimated for different network paths from the computing device to a variety of entry servers in the distributed server network. Based on the estimated performance metrics, one or more entry servers are then selected to receive the data stream from the computing device. As a result, the systems and methods described herein allow for high quality upload performance which addresses the first mile vulnerability issues of the data stream. The distributed server network can then transmit copies of the data stream in real-time to other computing devices.

Abstract: The present invention features assays for co-culturing primary cells while maintaining key biological activities specific to the primary cells. The invention is based, at least in part, on the discovery that compositions and methods for primary cells in a high-throughput co-culture platform, image analysis for distinguishing cells in co-cultures and assays that are suitable for screening of agents in epithelial cells, such as hepatocytes.

Abstract: Systems and methods described herein utilize a distributed server network to allow for the real-time distribution of copies of a data stream uploaded from a computing device. The uploaded data stream corresponds to an environment surrounding a user (exam taker) of the computing device during execution of a testing routine for an examination. Providing copies of the data stream in real-time allows proctors as well as other test assessment authorities to ‘peek in on the exam taker's environment during the exam. As a result, the environment surrounding the exam taker can be monitored in real-time to determine whether any visual or audio activity in the environment constitutes activity not in accordance with the exam protocol. Following an affirmative determination that the exam taker violated an exam taking protocol, a proctor or other test assessment authority can then make a final or early decision regarding disciplinary action.