Abstract: A tip to be placed on a fluid-ejection device is filled with fluid. The fluid may be introduced into a substantially hollow body of the tip at a first end of the body. The body of the tip has a second end at which a fluid-ejection mechanism is disposed to eject the fluid as controlled by the fluid-ejection device. The fluid may be introduced into the substantially hollow body of the tip through of the fluid-ejection mechanism disposed at the second end of the body of the tip. The tip may further be identified and/or serviced, and the tip and/or the fluid-ejection device may further be validated.

Abstract: Endoprosthesis, such as a stent, includes at least one annular element defined by a first set of strut members interconnected to define apices proximate opposite sides of the annular element. The annular element further includes a foot extension extending between at least one pair of circumferentially-adjacent strut members. The foot extension has first and second foot portions extending circumferentially from corresponding ends of the circumferentially-adjacent strut members, and are contoured to provide at least two areas of flexure. The first and second foot portions are joined at a toe portion of the foot extension, and define a circumferentially-directed apex between the pair of circumferentially-adjacent strut members. Preferably, at least one or more additional annular elements, each defined by interconnected strut members, are provided. The annular elements are generally expandable between a delivery configuration and a deployed configuration.

Abstract: A kinetic energy rotation system is disclosed which comprises a plurality of wind powered generators. A motor rotates the wind powered generators in a horizontal plane and stores kinetic energy due to the rotating mass of the wind powered generators and its support platform. As electricity is generated by the wind powered generators, a portion of the generated electricity is fed back into the motor to maintain the rotation of the wind powered generators. Excess electricity may be redirected to the city's electrical grid, or other local electrical needs.

Abstract: Positioning instruments and related methods are described for implanting an energy absorbing system for treating joints. The positioning instruments and methods allow the energy absorbing system to be positioned at a joint such that the desired motion will occur for the particular design of a particular energy absorbing system which is to be implanted. The positioning instruments include a locating instrument for locating an anatomical feature and a target location for implantation of the energy absorbing system, a verification instrument for verification of the target location, a placement guide for guiding placement of a part of the energy absorbing system, and positioning device for aligning portions of the energy absorbing system.

Abstract: A fluid-ejection device includes a handheld and/or mountable enclosure, a pneumatic fitting, an electrical connector, and a controller. The pneumatic fitting extends from and/or through the enclosure and is receptive to placement of a tip thereon. The tip contains a supply of fluid, a fluid-ejection mechanism, and an electrical connector for the fluid-ejection mechanism. The electrical connector extends from and/or through the enclosure and is receptive to electrical coupling of the electrical connector of the tip. The controller is situated within the enclosure to cause the tip to eject the fluid via the electrical coupling of the electrical connectors of the tip and the fluid-ejection device.

Abstract: A system and method for electronic wallet conversion allows conversion of a basic electronic wallet to a more flexible wallet account, providing additional services and requiring additional authentication. The basic accountholder eventually requires the additional services provided by the more flexible wallet, typically editing rights and making purchases at sites requiring authentication beyond the basic level. To convert the account, the account holder is presented with a one-time challenge and response mechanism that requires the accountholder to summon information that only the account holder would know. If a successful match is made, the account is converted to the more flexible account for all time. The accountholder replaces the one-time challenge and response with a second-level password that grants the accountholder ongoing access to more sensitive wallet features, such as the ability to purchase at sites requiring a second-level password, and editing rights to the information stored in the wallet.

Abstract: Endoprosthesis, such as a stent, includes at least one annular element defined by a first set of strut members interconnected to define apices proximate opposite sides of the annular element. The annular element further includes a foot extension extending between at least one pair of circumferentially-adjacent strut members. The foot extension has first and second foot portions extending circumferentially from corresponding ends of the circumferentially-adjacent strut members, and are contoured to provide at least two areas of flexure. The first and second foot portions are joined at a toe portion of the foot extension, and define a circumferentially-directed apex between the pair of circumferentially-adjacent strut members. Preferably, at least one or more additional annular elements, each defined by interconnected strut members, are provided. The annular elements are generally expandable between a delivery configuration and a deployed configuration.

Abstract: The present invention relates to a class of small molecule hydroxamic acid compounds capable of inhibiting histone deacetylases (HDACs). The present invention also relates to methods of preparation of hydroxamic acid HDAC inhibitor compounds of the invention, which are N-substituted-1,2,3,4-tetrahydroisoquinoline hydroxamic acid derivatives, and their incorporation into pharmaceutical compositions and methods of administration. The present invention also relates to N-substituted-1,2,3,4-tetrahydroisoquinoline hydroxamic acid derivatives, which may be prepared as a hydroxamic acid HDAC inhibitor compound library that can be utilized in screening methods known in the art.

Abstract: Generally, the present disclosure includes a hybrid segmented endoprosthesis for delivery into a lumen of a body. The hybrid segmented endoprosthesis has different types of segments that are joined together. The segments are typically distinct and distinguishable from each other by each segment having a unique configuration different from at least one other segment. Additionally, the segments can be coupled together by various processes well known for interconnecting the materials of endoprostheses. The segmented endoprosthesis can provide improved deliverability, strength, flexibility, and/or functionality during and after deployment. The use of a segmented endoprosthesis can combine the configurations of multiple small endoprostheses into a standard- or regular-sized endoprosthesis.

Abstract: Internal braces and methods of implanting same. A brace can be implanted on one side of a joint, or a pair of braces can be implanted, one on each opposite side of a joint. Each brace supports the joint over at least a portion of its range of motion. Distraction may be provided, or load sharing can be accomplished without distraction. Relative axial rotation of the bones connected by the brace may be permitted. One or more compliant members may be provided in the brace.

Abstract: A stent crimping apparatus is provided which includes a crimping assembly adapted to crimp the stent, a clamp assembly configured to secure the medical device; and a control unit configured to control the movement of the crimp assembly. The clamp assembly includes a lower clamp device defining a seating groove formed and dimensioned to seat a portion of the medical device therein, and a retaining assembly having an elastomeric member. This elastomeric member defines a contacting groove oriented in an opposed manner proximate to at least a portion of the seating groove. The clamp assembly further includes an actuation mechanism associated with the retaining assembly and the lower clamp device such that operation thereof causes the retaining assembly to move between an opened condition and a closed condition.

Abstract: The present invention provides binding proteins and antigen-binding fragments thereof that specifically bind to the human interleukin-21 receptor (IL-21R). The binding proteins can act as, e.g., antagonists of IL-21R activity, thereby modulating immune responses in general, and those mediated by IL-21R in particular. The disclosed compositions and methods may be used, e.g., in diagnosing and/or treating IL-21R-associated disorders, e.g., inflammatory disorders, autoimmune diseases, allergies, transplant rejection, cancer, and other immune system disorders.

Abstract: Endoprosthesis, such as a stent, includes at least one annular element defined by a first set of strut members interconnected to define apices proximate opposite sides of the annular element. The annular element further includes a foot extension extending between at least one pair of circumferentially-adjacent strut members. The foot extension has first and second foot portions extending circumferentially from corresponding ends of the circumferentially-adjacent strut members, and are contoured to provide at least two areas of flexure. The first and second foot portions are joined at a toe portion of the foot extension, and define a circumferentially-directed apex between the pair of circumferentially-adjacent strut members. Preferably, at least one or more additional annular elements, each defined by interconnected strut members, are provided. The annular elements are generally expandable between a delivery configuration and a deployed configuration.