Patents by Inventor David Lust

David Lust has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PEDIATRIC NIRAPARIB FORMULATIONS AND PEDIATRIC TREATMENT METHODS
    Publication number: 20210030735
    Abstract: The present invention relates to methods of treating cancer in pediatric subjects comprising administration of compound niraparib in a suitable oral dosage form and optionally in combination with a second therapeutic agent such as a PD-1 inhibitor.
    Type: Application
    Filed: February 5, 2019
    Publication date: February 4, 2021
    Inventors: Simon McGurk, David Lust, Kevin Johnston, Duantel Verwijs, Aaron Nelson, Clare Medendorp, Melanie Ronsheim, John Chaber, Steve Ruddy, Katie Poutsiaka, Danny van Hoorn, Aileen Dowling
  • Band device for a wheel rim
    Patent number: 7040365
    Abstract: An assembly (10) for location around a wheel rim (32) includes an annular support band (12) being formed of a relatively inextensible material. The support band (12) is split at at least one circumferential location to define a pair of opposed ends (16, 18). Adjustment bolt (24) is operably connected to the opposed ends (16, 18) for enabling adjustment of the diameter of the support band (12), and feet (14) depend from the radially inner face (34) of the support band (12). The feet (14) are formed from a relatively non-compressible material and, in use, are seated upon the wheel rim (32) to maintain the support band (12) in a spaced apart relationship with the wheel rim (32). The assembly may be adapted for use as a runflat assembly or as a beadlock assembly.
    Type: Grant
    Filed: May 16, 2001
    Date of Patent: May 9, 2006
    Assignee: Tyron Automotive Group Limited
    Inventor: Richard David Lüst
  • Band device for a wheel rim
    Publication number: 20030160501
    Abstract: An assembly (10) for location around a wheel rim (32) comprises an annular support band (12) being formed of a relatively inextensible material. The support band (12) is split at at least one circumferential location to define a pair of opposed ends (16, 18). Adjustment means (24, 26, 28) are operably connected to said opposed ends (16, 18) for enabling adjustment of the diameter of the support band (12), and spacing means (14) depend from the radially inner face (34) of the support band (12). The spacing means (14) is formed from a relatively non-compressible material and, in use, is seated upon the wheel rim (32) to maintain the support band (12) in a spaced apart relationship with the wheel rim (32). The assembly may be adapted for use as a runflat assembly or as a beadlock assembly.
    Type: Application
    Filed: March 31, 2003
    Publication date: August 28, 2003
    Inventor: Richard David Lust
  • Enzymatic oxidative deamination process
    Patent number: 6515170
    Abstract: The present invention concerns an enzymatic oxidative deamination process of a dipeptide monomer to prepare an intermediate useful to prepare compounds having endopeptidase and angiotensin converting enzyme inhibition activity.
    Type: Grant
    Filed: April 26, 2001
    Date of Patent: February 4, 2003
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Ramesh N. Patel, Amit Banerjee, Venkata B. Nanduri, Steven L. Goldberg, Robert M. Johnston, Thomas P. Tully, Laszlo J. Szarka, Shankar Swaminathan, John J. Venit, Jerome L. Moniot, William J. Winter, Neal G. Anderson, David A. Lust, Gerard Crispino, Sushil K. Srivastava
  • Enzymatic oxidative deamination process
    Patent number: 6261810
    Abstract: The present invention concerns an enzymatic oxidative deamination process of a dipeptide monomer to prepare an intermediate useful to prepare compounds having endopeptidase and angiotensin converting enzyme inhibition activity.
    Type: Grant
    Filed: August 31, 1999
    Date of Patent: July 17, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: Ramesh N. Patel, Amit Banerjee, Venkata B. Nanduri, Laszlo J. Szarka, Shankar Swaminathan, John J. Venit, Jerome L. Moniot, David A. Lust, Sushil K. Srivastava
  • Process for direct isolation of captopril
    Patent number: 5026873
    Abstract: A process is disclosed for direct isolation of captopril from a substrate of the formula ##STR1## wherein R is lower alkyl or lower alkoxy. In this process, the substrate is first treated with an aqueous alkali metal hydroxide capable of forming a water-soluble salt of the substrate, wherein the alkali metal hydroxide has a concentration of 4M or greater. The substrate is then neutralized, preferably with a mineral acid. By this process, captopril may be directly crystallized from an aqueous solution, avoiding the prior art use of organic solvents and zinc treatment to reduce levels of sulfide and disulfide impurities, respectively. In an alternative embodiment, neutralization is carried out by use of a hydrogen-supplying ion exchange resin.
    Type: Grant
    Filed: November 6, 1989
    Date of Patent: June 25, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Neal G. Anderson, David A. Lust, Barbara J. Bennett, Alan F. Feldman, Robert E. Polomski
  • Process for stereochemically inverting a hydroxy function of an ester by a modified Mitsunobu reaction process
    Patent number: 4912230
    Abstract: A process is provided for inverting a hydroxy function of a L-trans-hydroxy proline derivative to the corresponding L-cis-hydroxy proline sulfonate by a Modified Mitsunobu reaction process.
    Type: Grant
    Filed: September 16, 1988
    Date of Patent: March 27, 1990
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Neal G. Anderson, Christopher M. Cimarusti, David A. Lust