Patents by Inventor David Álvaro Cebrián Muñoz

David Álvaro Cebrián Muñoz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Macrocyclic compounds as protein kinase inhibitors
    Patent number: 9808466
    Abstract: There is provided compounds of formula I, wherein R1, R2a, R2b, R2c, X, Y, Z, R3 and ring A/B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. PI3-K, particularly class I PI3K, PIM family kinase and/or mTOR) is desired and/or required, and particularly in the treatment of cancer. The invention also relates to combinations containing such compounds.
    Type: Grant
    Filed: January 26, 2016
    Date of Patent: November 7, 2017
    Inventors: Joaquín Pastor Fernández, Rosa María Álvarez Escobar, Rosario Concepción Riesco Fagundo, Ana Belén García García, Antonio Rodríguez Hergueta, Jose Ignacio Martín Hernando, Carmen Blanco Aparicio, David Álvaro Cebrián Muñoz
  • MACROCYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS
    Publication number: 20160296528
    Abstract: There is provided compounds of formula I, wherein R1, R2a, R2b, R2c, X, Y, Z, R3 and ring A/B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. PI3-K, particularly class I PI3K, PIM family kinase and/or mTOR) is desired and/or required, and particularly in the treatment of cancer. The invention also relates to combinations containing such compounds.
    Type: Application
    Filed: January 26, 2016
    Publication date: October 13, 2016
    Inventors: Joaquin Pastor Fernández, Rosa María Álvarez Escobar, Rosario Concepción Riesco Fagundo, Ana Belén García García, Antonio Rodríguez Hergueta, Jose Ignacio Martín Hernando, Carmen Blanco Aparicio, David Álvaro Cebrián Muñoz
  • Chemical entities
    Patent number: 9453031
    Abstract: Provided are chemical entities selected from compounds of formula (I), wherein R1, R2 and m have meanings given in the description, and pharmaceutically acceptable salts, solvates and stereoisomers thereof, which are inhibitors of ATR and are potentially useful in the treatment of cancer. Further provided are pharmaceutical compositions of the chemical entities, combination products containing the chemical entities, the use of the compositions as therapeutic agents, and methods of treatment using these compositions.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: September 27, 2016
    Assignee: Fundación Centro Nacional de Investigaciones Oncológicas Carlos III
    Inventors: Joaquín Pastor Fernández, Oscar Fernández-Capetillo Ruiz, Sonia Martínez González, Carmen Blanco Aparicio, María del Rosario Rico Ferreira, Luis Ignacio Toledo Lázaro, Sonsoles Rodríguez Arísteguí, Matilde Murga Costa, Carmen Varela Busto, Andrés Joaquín Lopez Contreras, Oliver Renner, María Nieto Soler, David Alvaro Cebrián Muñoz
  • Macrocyclic compounds as protein kinase inhibitors
    Patent number: 9284334
    Abstract: There is provided compounds of formula I, wherein R1, R2a, R2b, R2c, X, Y, Z, R3 and ring A/B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. PI3-K, particularly class I PI3K, PIM family kinase and/or mTOR) is desired and/or required, and particularly in the treatment of cancer. The invention also relates to combinations containing such compounds.
    Type: Grant
    Filed: May 18, 2012
    Date of Patent: March 15, 2016
    Assignee: Fundación Centro Nacional de Investigaciones Oncologicas Carlos III
    Inventors: Joaquin Pastor Fernández, Rosa Maria Álvarez Escobar, Rosario Concepción Riesco Fagundo, Ana Belén García García, Antonio Rodriguez Hergueta, Jose Ignacio Martín Hernando, Carmen Blanco Aparicío, David Álvaro Cebrián Muñoz
  • CHEMICAL ENTITIES
    Publication number: 20160024112
    Abstract: Provided are chemical entities selected from compounds of formula (I), wherein R1, R2 and m have meanings given in the description, and pharmaceutically acceptable salts, solvates and stereoisomers thereof, which are inhibitors of ATR and are potentially useful in the treatment of cancer. Further provided are pharmaceutical compositions of the chemical entities, combination products containing the chemical entities, the use of the compositions as therapeutic agents, and methods of treatment using these compositions.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 28, 2016
    Inventors: Joaquín Pastor Fernández, Oscar Fernández-Capetillo Ruiz, Sonia Martínez González, Carmen Blanco Aparicio, María del Rosario Rico Ferreira, Luis Ignacio Toledo Lázaro, Sonsoles Rodríguez Arísteguí, Matilde Murga Costa, Carmen Varela Busto, Andrés Joaquín Lopez Contreras, Oliver Renner, María Nieto Soler, David Alvaro Cebrián Muñoz
  • MACROCYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS
    Publication number: 20140256717
    Abstract: There is provided compounds of formula I, wherein R1, R2a, R2b, R2c, X, Y, Z, R3 and ring A/B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. PI3-K, particularly class I PI3K, PIM family kinase and/or mTOR) is desired and/or required, and particularly in the treatment of cancer. The invention also relates to combinations containing such compounds.
    Type: Application
    Filed: May 18, 2012
    Publication date: September 11, 2014
    Applicant: Centro Nacional de Investigaciones Oncológicas (CNIO)
    Inventors: Joaquín Pastor Fernández, Rosa Maria Álvarez Escobar, Rosario Concepción Riesco Fagundo, Ana Belén García García, Antonio Rodríguez Hergueta, Jose Ignacio Martin Hernando, Carmen Blanco Aparicio, David Álvaro Cebrián Muñoz