Patents by Inventor David M. Barnes

David M. Barnes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SALT AND CRYSTALLINE FORMS THEREOF OF A DRUG
    Publication number: 20100286397
    Abstract: A crystalline form of a drug, ways to make it, compositions containing it and methods of treatment of diseases and inhibition of adverse physiological events using it are disclosed.
    Type: Application
    Filed: April 20, 2010
    Publication date: November 11, 2010
    Inventors: Geoff G.Z. Zhang, Michael F. Bradley, David M. Barnes, Rodger Henry
  • SALT AND CRYSTALLINE FORMS THEREOF OF A DRUG
    Publication number: 20100261703
    Abstract: A crystalline form of a drug, ways to make it, compositions containing it and methods of treatment of diseases and inhibition of adverse physiological events using it are disclosed.
    Type: Application
    Filed: February 5, 2010
    Publication date: October 14, 2010
    Applicant: Abbott Laboratories
    Inventors: Geoff G.Z. Zhang, Michael F. Bradley, David M. Barnes, Rodger Henry
  • OCTAHYDRO-PYRROLO[3,4-B]PYRROLE DERIVATIVES
    Publication number: 20100222358
    Abstract: Octahydro-pyrrolo[3,4-b]pyrrole derivatives are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Octahydro-pyrrolo[3,4-b]pyrrole compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein.
    Type: Application
    Filed: March 2, 2010
    Publication date: September 2, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Marlon D. Cowart, Chen Zhao, Minghua Sun, Lawrence A. Black, Guo Zhu Zheng, Robert J. Gregg, Geoff G.Z. Zhang, Ahmad Y. Sheikh, Xiaochun Lou, Rodger F. Henry, David M. Barnes, Lawrence Kolaczkowski, Anthony R. Haight, Sou-Jen Chang, Steven J. Wittenberger, Michael G. Fickes
  • Salt and crystalline forms thereof of a drug
    Patent number: 7728143
    Abstract: A crystalline form of a drug, ways to make it, compositions containing it and methods of treatment of diseases and inhibition of adverse physiological events using it are disclosed.
    Type: Grant
    Filed: October 7, 2005
    Date of Patent: June 1, 2010
    Assignee: Abbott Laboratories
    Inventors: Geoff G. Z. Zhang, Michael F. Bradley, David M. Barnes, Rodger Henry
  • PREPARATION OF PYRIDONECARBOXYLIC ACID ANTIBACTERIALS
    Publication number: 20100041890
    Abstract: A process for making 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid, and therapeutically acceptable salts thereof, and intermediates used in the process are disclosed.
    Type: Application
    Filed: August 18, 2009
    Publication date: February 18, 2010
    Inventors: Anthony Haight, David M. Barnes, Geoff G.Z. Zhang
  • Preparation of pyridonecarboxylic acid antibacterials
    Patent number: 7576216
    Abstract: A process for making 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid, and therapeutically acceptable salts thereof, and intermediates used in the process are disclosed.
    Type: Grant
    Filed: July 28, 2005
    Date of Patent: August 18, 2009
    Assignee: Abbott Laboratories
    Inventors: Anthony Haight, David M. Barnes, Geoff G. Z. Zhang
  • VITAMIN D RECEPTOR ACTIVATORS AND METHODS OF MAKING
    Publication number: 20090131379
    Abstract: The invention relates to compounds that are vitamin D receptor activators, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.
    Type: Application
    Filed: September 8, 2008
    Publication date: May 21, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: Thomas W. Von Geldern, Jufang H. Barkalow, David M. Barnes, Anthony R. Haight, John E. Hengeveld, Xiaofeng Li, Maureen A. McLaughlin, William T. Noonan, Zhonghua Pei, Jinshyun Ruth Wu-Wong
  • Sulfonamides having antiangiogenic and anticancer activity
    Patent number: 7491718
    Abstract: Compounds having methionine aminopeptidase-2 inhibitory (MetAP2) are described. Also described are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.
    Type: Grant
    Filed: October 8, 2003
    Date of Patent: February 17, 2009
    Assignee: Abbott Laboratories
    Inventors: Kenneth M. Comess, Scott A. Erickson, Jack Henkin, Douglas M. Kalvin, Megumi Kawai, Ki H. Kim, Nwe Y. BaMaung, Chang Hoon Park, George S. Sheppard, Anil Vasudevan, Jieyi Wang, David M. Barnes, Steve D. Fidanze, Lawrence Kolaczkowski, Robert A. Mantei, David C. Park, William J. Sanders, Jason S. Tedrow, Gary T. Wang
  • Deposition of samples and sample matrix for enhancing the sensitivity of matrix assisted laser desorption/ionization mass spectrometry
    Patent number: 7095018
    Abstract: The present invention relates to small sample spots for MALDI targets and methods for producing the same. The sample spots are composed of a layer of matrix material and a layer of analyte. In some instances, the samples spots have diameters of no more than 50 micrometers or even smaller. The sample spots are deposited onto a MALDI target substrate using ultrasonic deposition from a nozzle.
    Type: Grant
    Filed: December 29, 2004
    Date of Patent: August 22, 2006
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: David M. Barnes, Bradley J. Larson, Max G. Lagally, Martha M. Vestling
  • Method and composition for prolonging the residence time of drugs in the gut
    Publication number: 20040192638
    Abstract: The present invention provides methods and compositions for slowing the transit time of foodstuffs, pharmaceutical compounds, nutritional supplements, and vitamins through the gastrointestinal tract using cyclic GMP (cGMP) alone and cGMP in combination with succinate. The method and corresponding compositions prolong residence time of such compounds, and thereby increase absorption through the small intestine, increase bioavailability, and improve feed conversion ratios.
    Type: Application
    Filed: April 7, 2004
    Publication date: September 30, 2004
    Inventors: John A. Oaks, Paul Bass, David M. Barnes, Noah P. Zimmerman
  • Sulfonamides having antiangiogenic and anticancer activity
    Publication number: 20040167128
    Abstract: Compounds having methionine aminopeptidase-2 inhibitory (MetAP2) are described. Also described are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.
    Type: Application
    Filed: October 8, 2003
    Publication date: August 26, 2004
    Inventors: Kenneth M. Comess, Scott A. Erickson, Jack Henkin, Douglas M. Kalvin, Megumi Kawai, Ki H. Kim, Nwe Y. BaMaung, Chang Hoon Park, George S. Sheppard, Anil Vasudevan, Jieyi Wang, David M. Barnes, Steve D. Fidanze, Lawrence Kolaczkowski, Robert A. Mantei, David C. Park, William J. Sanders, Jason S. Tedrow, Gary T. Wang
  • Sulfonamides having antiangiogenic and anticancer activity
    Publication number: 20040157836
    Abstract: Compounds having methionine aminopeptidase-2 inhibitory (MetAP2) are described. Also described are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.
    Type: Application
    Filed: September 23, 2003
    Publication date: August 12, 2004
    Inventors: Kenneth M. Comess, Scott A. Erickson, Jack Henkin, Douglas M. Kalvin, Megumi Kawai, Ki H. Kim, Nwe Y. BaMaung, Chang Hoon Park, George S. Sheppard, Anil Vasudevan, Jieyi Wang, David M. Barnes, Steve D. Fidanze, Lawrence Kolaczkowski, Robert A. Mantei, David C. Park, William J. Sanders, Jason S. Tedrow, Gary T. Wang
  • Stereoselective process for producing nitro compounds
    Patent number: 6329536
    Abstract: The present invention relates to producing stereoselective nitro compounds by reacting a dicarbonyl compound with a nitrostyrene compound in the presence of a catalyst complex and a base.
    Type: Grant
    Filed: September 16, 1999
    Date of Patent: December 11, 2001
    Assignee: Abbott Laboratories
    Inventors: Jianguo Ji, David M. Barnes, Steve King, Frederick A. Plagge, Steven J. Wittenberger, Ji Zhang