Patents by Inventor David M. Blum

David M. Blum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for preparing glutamic acid derivatives
    Patent number: 7541485
    Abstract: The present invention relates to novel methods for the preparation of glutamic acid derivatives and intermediates thereof, and such compounds prepared by the novel methods.
    Type: Grant
    Filed: July 11, 2006
    Date of Patent: June 2, 2009
    Assignee: Wyeth
    Inventors: Ronald S. Michalak, Joseph Zeldis, Mel Jennings, David M. Blum, Timothy Doyle
  • Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts
    Patent number: 7419982
    Abstract: The present invention relates to crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts; processes for the production thereof; pharmaceutical compositions thereof; and methods for inhibiting tumor growth therewith.
    Type: Grant
    Filed: May 19, 2006
    Date of Patent: September 2, 2008
    Assignee: Wyeth Holdings Corporation
    Inventors: Fang Fang Qi, Mannching Sherry Ku, Yanzhong Wu, David M. Blum
  • Methods for preparing glutamic acid derivatives and intermediates thereof
    Publication number: 20080119670
    Abstract: The present invention relates to novel methods for the preparation of glutamic acid derivatives and intermediates thereof, and such compounds prepared by the novel methods.
    Type: Application
    Filed: June 1, 2007
    Publication date: May 22, 2008
    Applicant: Wyeth
    Inventors: Timothy Doyle, Joseph Zeldis, Ronald S. Michalak, David M. Blum, Mel Jennings, Julianne Blum
  • Synthesis and purification of [R-(R*,R*)]-5-[2-[5-(3-chloro-phenyl)-2-oxo-3-oxazolidinyl]-propyl]-1,-3 -benzodiozole-2,2-dicarboxylic acid dimethyl ester
    Patent number: 5461163
    Abstract: The invention relates to a process improvement for making [R-(R*,R*)]-5-[2-[5-(3-chlorophenyl)-2-oxo-3-oxazolidinyl]propyl]-1,3-benz odioxole-2,2-dicarboxylic acid dimethyl ester an intermediate used in the synthesis of beta-3 agonist, [R-(R*,R*)]-5-[2-[5-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benz odioxole-2,2-dicarboxylic acid disodium salt.
    Type: Grant
    Filed: June 6, 1994
    Date of Patent: October 24, 1995
    Assignee: American Cyanamid Company
    Inventors: Christine P. Bellon, David M. Blum, William T. Cain
  • Process for the synthesis [R-(R*-,R*-)]-5-(3-chlorophenyl-3-[2-(3,4-dihydroxyphenyl)-1-methylethyl]- 2
    Patent number: 5438148
    Abstract: The invention is the simultaneous addition of boron tribromide and a solution of [R-(R*,R*)]-5-(3-chlorophenyl-3-[2-(3,4-dimethoxyphenyl)-1-methylethyl]-2- oxazolidinone in methylene chloride to methylene chloride while maintaining a constant ratio of 2.10:1.00 of boron tribromide to the substrate [R-(R*,R*)]-5-(3-chlorophenyl-3-[2-(3,4-dimethoxyphenyl)-1-methylethyl]-2- oxazolidinone at a temperature of -5.degree. C. to 10.degree. C. gives [R-(R*,R*)]-5-(3-chlorophenyl-3-[2-(3,4-hydroxyoxyphenyl)-1-methylethyl]-2 -oxazolidinone in an isolated yield of 86.7% and a purity of 98.7%.
    Type: Grant
    Filed: September 20, 1994
    Date of Patent: August 1, 1995
    Assignee: American Cyanamid Company
    Inventors: Arthur G. Mohan, David M. Blum
  • Process for the synthesis of acetic acid, (dimethoxyphosphinyl) [[1,1-dimethylethyl)dimethylsilyl]-oxy]-, (4-nitrophenyl) methyl ester
    Patent number: 5288888
    Abstract: The invention is an improved process for the large scale production of acetic acid, (dimethoxyphosphinyl) [[1,1-dimethylethyl)dimethylsilyl]oxy]-, (4-nitrophenyl)methyl ester.
    Type: Grant
    Filed: April 28, 1993
    Date of Patent: February 22, 1994
    Assignee: American Cyanamid Company
    Inventors: Kenneth E. Green, Edward R. Ruso, Mellard N. Jennings, Alex R. Jurgens, David M. Blum, Gregg B. Feigelson
  • Process for the synthesis of 5-[(substituted amino]-8-[phenyl or substituted-phenyl]-3H,6H-1,4,5A,8A-tetraazaace-naphthylen-3-ones and intermediates therefor
    Patent number: 5247086
    Abstract: A novel process for producing 5-[(substituted)amino]-8-[phenyl or substituted-phenyl]-3H,6H-1,4,5a,8a-tetraazaace-naphthylen-3-ones of the formula: ##STR1## Where R.sub.1, R.sub.2 and R.sub.3 are defined in the specification by reacting a 4,5-dihydro-7-[phenyl or substituted phenyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide with carbon disulfide and a suitable base and a lower alkyl iodide to give a 5-(lower alkylthio)-8-[phenyl or substituted phenyl]-3H,6H-1,4,5a,8a-tetraazaacenaphthylen-3-one which is further reacted with an amine of the formula: ##STR2## to give the desired compounds is disclosed as well as 5-(loweralkylthio)-8-phenyl-3H,6H,1,4,5a,8a-tetra azaacenaphthylen-3-ones useful as intermediates in the process.
    Type: Grant
    Filed: January 27, 1993
    Date of Patent: September 21, 1993
    Assignee: American Cyanamid Company
    Inventors: William T. Cain, Edward Ruso, David M. Blum, Ian Cutting
  • Process for the preparation of 3'- or 2'-halo-substituted-2',3'-dideoxynucleosides
    Patent number: 5231175
    Abstract: A process for the preparation of 2' and 3'-(halo-substituted)-2',3'-dideoxy nucleosides by reacting a protected anhydrothymidine compound with a halogenating composition containing a transition metal or lanthanide compound.
    Type: Grant
    Filed: February 10, 1992
    Date of Patent: July 27, 1993
    Assignee: American Cyanamid Company
    Inventors: Kenneth E. Green, David M. Blum, Michael P. Trova
  • Process for producting 10-phenyl-10H-phenoxaphoshine
    Patent number: 4698447
    Abstract: An improved, simplified process for producing 10-phenyl-10H-phenoxaphosphine in a yield of about 55% comprising reacting n-butyl lithium in a nonpolar hydrocarbon with diphenyl ether in tetramethylethylenediamine and diethyl ether, adding phenyl phosphonous dichloride and then water, and recovering the final product.
    Type: Grant
    Filed: March 14, 1986
    Date of Patent: October 6, 1987
    Assignee: American Cyanamid Company
    Inventor: David M. Blum