Abstract: The present disclosure provides antibodies specific for Mucin 1. Nucleic acids that encode one or both of the variable chains of an antibody of the present disclosure are also provided, as are cells that include such nucleic acids. Also provided are compositions that include the antibodies of the present disclosure, including in some instances, pharmaceutical compositions. Methods of making and using the antibodies of the present disclosure are also provided. In certain aspects, provided are methods that include administering to an individual having a cell proliferative disorder a therapeutically effective amount of an antibody of the present disclosure, where the antibody is administered to the individual to enhance an immune response, e.g., a T cell response, to abnormally proliferating cells of the cell proliferative disorder. The antibodies are also useful in various diagnostic, and monitoring applications, which are also provided.

Abstract: An infrared source for use in an infrared spectrometer includes an insulator core having a containment cavity, an outlet port in communication with the containment cavity, and an electrically heated infrared element mounted in the containment cavity with a portion thereof facing the outlet port and with the walls of the containment cavity closely spaced to the infrared element. The insulator core is formed of a ceramic fiber material which has excellent resistance to heat and very low thermal conductivity so that very little heat from the infrared element escapes from the insulator core except as infrared radiation through the outlet port. The insulator core is preferably mounted within a central cavity of a metal housing, and may be sealed off from the ambient atmosphere by an infrared transmissive window sealed to an outlet opening in the housing.