Patents by Inventor David M. Fink
David M. Fink has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120305083Abstract: A co-extruded multi-layer plastic pipe and method of manufacture are disclosed in which a first extruder melts and extrudes a first plastic material into the outer annulus of a coaxial extrusion die to form an outer pipe layer, and a second extruder melts and extrudes a highly oxidation-resistant plastic material into the inner annulus of said coaxial extrusion die under a blanket of inert gas to create an inner pipe layer, whereby the outer and inner pipe layers are fused together under the protection of the inert gas blanket which prevents premature degradation of the oxidation-resistant inner layer until the finished extruded pipe has cooled and solidified.Type: ApplicationFiled: June 4, 2011Publication date: December 6, 2012Applicant: WLP HOLDING CORPORATIONInventors: Michael E. Dahl, David M. Fink
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Patent number: 7511046Abstract: The compounds are of the class thienoisoxazolyl- and thienylpyrrazolyl-phenoxy substituted propyl derivatives, useful as D4 antagonists. Said compounds are useful for the treatment of medical conditions mediated by inhibition of D4 receptor. These conditions comprise, for example, Attention Deficit Hyperactivity Disorder, Obsessive-Compulsive Disorder, Psychoses, Substance Abuse, Substance Dependence, Parkinson's Disease, Parkinsonism, Tardive Diskinesia, Gilles de la Tourette Syndrome, Conduct Disorder, and Oppositional Defiant Disorder. A further aspect of the invention is to provide a pharmaceutical composition, intermediates, and a method of making said class of compounds.Type: GrantFiled: July 21, 2006Date of Patent: March 31, 2009Assignee: Aventis Hoklings Inc.Inventors: David M Fink, Brian S Freed, Nicholas J Hrib, Raymond W Kosley, George E Lee, Gregory H Merriman, Barbara S Rauckman
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Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as Dantagonists
Patent number: 7125903Abstract: The compounds are of the class thienoisoxazolyl- and thienylpyrrazolyl-phenoxy substituted propyl derivatives, useful as D4 antagonists. Said compounds are useful for the treatment of medical conditions mediated by inhibition of D4 receptor. These conditions comprise, for example, Attention Deficit Hyperactivity Disorder, Obsessive-Compulsive Disorder, Psychoses, Substance Abuse, Substance Dependence, Parkinson's Disease, Parkinsonism, Tardive Diskinesia, Gilles de la Tourette Syndrome, Conduct Disorder, and Oppositional Defiant Disorder. A further aspect of the invention is to provide a pharmaceutical composition, intermediates, and a method of making said class of compounds.Type: GrantFiled: September 13, 2000Date of Patent: October 24, 2006Assignee: Aventis Pharmaceuticals Inc.Inventors: David M. Fink, Brian S. Freed, Nicholas J. Hrib, Raymond W. Kosley, Jr., George E. Lee, Gregory H. Merriman, Barbara S. Rauckman -
Patent number: 6004977Abstract: Novel N-(pyridinylamino)isoindolines and related compounds, intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction and treating depression utilizing the N-(pyridinylamino)isoindolines and related compounds, the intermediates or compositions thereof are disclosed.Type: GrantFiled: October 29, 1997Date of Patent: December 21, 1999Assignee: Hoechst Marion Roussel, Inc.Inventors: Barbara E. Kurys, David M. Fink, Brian S. Freed, Gregory H. Merriman
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Patent number: 5948798Abstract: Novel pyridiniminyl-1,2-benzisoxazoles and -benzisothiazoles, intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction and treating depression utilizing the 1,2-benzisoxazoles and -benzisothiazoles and intermediates, or compositions thereof are disclosed.Type: GrantFiled: October 30, 1997Date of Patent: September 7, 1999Assignee: Hoechst Marion Roussel, Inc.Inventors: David M. Fink, Barbara E. Kurys, Gregory M. Shutske, John D. Tomer, IV
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Patent number: 5728717Abstract: Novel pyridiniminyl-1,2-benzisoxazoles and -benzisothiazoles, intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction and treating depression utilizing the 1,2-benzisoxazoles and -benzisothiazoles and intermediates, or compositions thereof are disclosed.Type: GrantFiled: February 26, 1997Date of Patent: March 17, 1998Assignee: Hoechst Marion Roussel Inc.Inventors: David M. Fink, Barbara E. Kurys, Gregory M. Shutske, John D. Tomer, IV
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Patent number: 5668154Abstract: Novel pyridiniminyl-1,2-benzisoxazoles and -benzisothiazoles, intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction and treating depression utilizing the 1,2-benzisoxazoles and -benzisothiazoles and intermediates, or compositions thereof are disclosed.Type: GrantFiled: May 2, 1996Date of Patent: September 16, 1997Assignee: Hoechst Marion Roussel Inc.Inventors: David M. Fink, Barbara E. Kurys, Gregory M. Shutske, John D. Tomer, IV
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Patent number: 5340936Abstract: This invention relates to compounds of the formula ##STR1## where X is --0--, --S--or --NH--;Y is hydrogen, halogen and loweralkoxy;p is 1 or 2;n is 2, 3 or 4;R is hydrogen, loweralkyl, loweralkoxy, hydroxy, halogen, amino, loweralkylamino, nitro, loweralkylthio, trifiuoromethoxy, cyano, trifluoromethyl, ##STR2## where aryl is ##STR3## R.sub.1 is hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, carboxyl, loweralkylamino, nitro, loweralkylthio, cyano, and trifluoromethyl;m is 1 or 2; a pharmaceutically acceptable acid addition salt thereof and, where applicable the geometric and optical isomers and racemic mixtures thereof.The compounds and compositions of this invention are useful as antipsychotic agent, as 5-HT.sub.3 receptor antagonists and as inhibitors of the reuptake of serotonin.Type: GrantFiled: March 25, 1993Date of Patent: August 23, 1994Assignee: Hoechst-Roussel Pharmaceuticals Inc.Inventors: Edward J. Glamkowski, David M. Fink, Barbara E. Kurys, Yulin Chiang
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Patent number: 5334599Abstract: This invention relates to compounds of the formula ##STR1## where X is --O--, --S-- or --NH--;Y is hydrogen, halogen and loweralkoxy;p is 1 or 2;n is 2, 3 or 4;R is hydrogen, loweralkyl, loweralkoxy, hydroxy, halogen, amino, loweralkylamino, nitro, loweralkylthio, trifiuoromethoxy, cyano, trifiuoromethyl, ##STR2## R.sub.1 is hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, carboxyl, loweralkylamino, nitro, loweralkylthio, cyano, and trifiuoromethyl;m is 1 or 2; a pharmaceutically acceptable acid addition salt thereof and, where applicable the geometric and optical isomers and racemic mixtures thereof.The compounds and compositions of this invention are useful as antipsychotic as 5-HT.sub.3 receptor antagonists and as inhibitors of the reuptake of serotonin.Type: GrantFiled: March 25, 1993Date of Patent: August 2, 1994Assignee: Hoechst-Roussel Pharmaceuticals Inc.Inventors: Edward J. Glamkowski, David M. Fink, Barbara E. Kurys, Yulin Chiang
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Patent number: 5264575Abstract: Novel 2,6-methano-1,3-benzodiazocines, intermediates, processes for the preparation thereof, and methods for alleviating pain and for alleviating various memory dysfunctions characterized by a decreased cholinergic function, such as Alzheimer's disease, utilizing compounds or compositions thereof are disclosed.Type: GrantFiled: June 19, 1992Date of Patent: November 23, 1993Assignee: Hoechst-Roussel Pharmaceuticals Inc.Inventors: Richard C. Allen, Marc N. Agnew, David M. Fink
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Patent number: 5234931Abstract: This invention relates to compounds of the formula ##STR1## where X is --O--, --S-- or --NH--;Y is hydrogen, halogen and loweralkoxy;p is 1 or 2;n is 2, 3 or 4;R is hydrogen, loweralkyl, loweralkoxy, hydroxy, halogen, amino, loweralkylamino, nitro, loweralkylthio, trifluoromethoxy, cyano, trifluoromethyl, ##STR2## R.sub.1 is hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, carboxyl, loweralkylamino, nitro, loweralkylthio, cyano, and trifluoromethyl;m is 1 or 2; a pharmaceutically acceptable acid addition salt thereof and, where applicable the geometric and optical isomers and racemic mixtures thereof.The compounds and compositions of this invention are useful as antipsychotic agents, as 5-HT.sub.3 receptor antagonists and as inhibitors of the reuptake of serotonin.Type: GrantFiled: February 4, 1992Date of Patent: August 10, 1993Assignee: Hoechst-Roussel Pharmaceuticals IncorporatedInventors: Edward J. Glamkowski, David M. Fink, Barbara E. Kurys, Yulin Chiang
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Patent number: 5204480Abstract: There are described compounds of the formula ##STR1## where n is 1, 2 or 3;R.sub.1 is hydrogen, formyl, loweralkylcarbonyl, arylloweralkylcarbonyl, loweralkyl, arylloweralkyl, ##STR2## R.sub.5 and R.sub.6 being independently loweralkyl or alternatively the group ##STR3## taken as a whole is ##STR4## R.sub.2 is hydrogen, loweralkyl, loweralkenyl, arylloweralkyl, --CH.sub.2 C.tbd.CH, ##STR5## R.sub.7 and R.sub.8 being independently loweralkyl or alternatively the group ##STR6## taken as a whole is ##STR7## R.sub.3 is hydrogen is loweralkyl; and R.sub.4 is hydrogen or loweralkyl;which compounds are useful as analgesic agents and also for treating various memory dysfunctions.Type: GrantFiled: February 21, 1992Date of Patent: April 20, 1993Assignee: Hoechst-Roussel Pharmaceuticals Inc.Inventors: Richard C. Effland, David M. Fink
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Patent number: 5112981Abstract: There are described compounds of the formula ##STR1## where n is 1, 2 or 3;R.sub.1 is hydrogen, formyl, loweralkylcarbonyl, arylloweralkylcarbonyl, loweralkyl, arylloweralkyl, ##STR2## R.sub.5 and R.sub.6 being independently loweralkyl or alternatively the group ##STR3## taken as a whole is ##STR4## R.sub.2 is hydrogen, loweralkyl, loweralkenyl, arylloweralkyl, --CH.sub.2 C.tbd.CH, ##STR5## R.sub.7 and R.sub.8 being independently loweralkyl or alternatively the group ##STR6## taken as a whole is ##STR7## R.sub.3 is hydrogen or loweralkyl; and R.sub.4 is hydrogen or loweralkyl;which compounds are useful as analgesic agents and also for treating various memory dysfunctions.Type: GrantFiled: June 5, 1991Date of Patent: May 12, 1992Assignee: Hoechst-Roussel Pharmaceuticals Inc.Inventors: Richard C. Effland, David M. Fink
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Patent number: 5097033Abstract: Novel 2,6-methano-1,3-benzodiazocines, intermediates, processes for the preparation thereof, and methods for alleviating pain and for alleviating various memory dysfunctions characterized by a decreased cholinergic function, such as Alzheimer's disease, utilizing compounds or compositions thereof are disclosed.Type: GrantFiled: January 9, 1991Date of Patent: March 17, 1992Assignee: Hoechst-Roussel Pharmaceuticals Inc.Inventors: Richard C. Allen, Marc N. Agnew, David M. Fink
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Patent number: 5039809Abstract: A compound of the formula: ##STR1## where n is 1, 2, or 3;R.sub.3 is hydrogen or loweralkyl;R.sub.4 is hydrogen or loweralkyl; andAr is a phenyl group optionally mono-substituted with a loweralkoxy, halogen or trifluoromethyl group which are useful as intermediates.Type: GrantFiled: October 9, 1990Date of Patent: August 13, 1991Assignee: Hoechst-Roussel Pharmaceuticals Inc.Inventors: Richard C. Effland, David M. Fink
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Patent number: 5010083Abstract: Novel 2,6-methano-1,3-benzodiazocines, intermediates, processes for the preparation thereof, and methods for alleviating pain and for alleviating various memory dysfunctions characterized by a decreased cholinergic function, such as Alzheimer's disease, utilizing compounds or compositions thereof are disclosed.Type: GrantFiled: December 6, 1989Date of Patent: April 23, 1991Assignee: Hoechst-Roussel Pharmaceuticals, Inc.Inventors: Richard C. Allen, Marc N. Agnew, David M. Fink
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Patent number: 4978663Abstract: There are described compounds of the formula ##STR1## where n is 1,2 or 3;R.sub.1 is hydrogen, formyl, loweralkylcarbonyl, arylloweralkylcarbonyl, loweralkyl, arylloweralkyl, ##STR2## R.sub.5 and R.sub.6 being independently loweralkyl or alternatively the group ##STR3## taken as a whole is ##STR4## R.sub.2 is hydrogen, loweralkyl, loweralkenyl, arylloweralkyl, --CH.sub.2 C.tbd.CH, R.sub.7 and R.sub.8 being independently loweralkyl or alternatively the group ##STR5## taken as a whole is ##STR6## R.sub.3 is hydrogen or loweralkyl; and R.sub.4 is hydrogen or loweralkyl;which compounds are useful as analgesic agents and also for treating various memory dysfunctions.Type: GrantFiled: August 16, 1989Date of Patent: December 18, 1990Assignee: Hoechst-Roussel Pharmaceuticals Inc.Inventors: Richard C. Effland, David M. Fink