Abstract: Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3? or C4? modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.

Abstract: The application relates to a compound having Formula X: which modulates the activity of HER2 and/or a mutant thereof, and/or EGFR and/or a mutant thereof, a pharmaceutical composition comprising the compound, and a method of treating or preventing a disease in which HER2 and/or a mutant thereof, and/or EGFR and/or a mutant thereof, plays a role.

Abstract: Computer-implemented functionality is described herein for assisting a user in interacting with an environment. In one implementation, the functionality operates by: determining that a particular user is within a prescribed proximity to an electronic sign, or will be in prescribed proximity to the electronic sign, based on sensor information provided by one or more sensors within the environment; determining an identity of the user; determining at least one destination of the user based at least on calendar information; providing directions to the destination(s), to provide unfiltered direction information; optionally filtering the unfiltered direction information with respect to restriction information (e.g., privacy information, security information, etc.), to produce filtered direction information; composing sign information based on the filtered direction information; and sending the sign information to the electronic sign for presentation by the sign.

Abstract: A receiver receives a request to schedule a meeting from a user and in response, prompts the user to provide meeting information including time information and attendee information for scheduling the meeting. A meeting scheduler identifies potential dates and potential times based on the meeting information. The meeting scheduler further detects locations of the attendees based on the potential dates and identifies potential meeting locations based on attendees' location. The meeting scheduler also computes date scores for the potential dates, time scores for the potential times, and location scores for the meeting locations to select a date, a time, and a meeting location based on scores to determine a meeting schedule. The meeting scheduler further selects a conferencing mechanism for the meeting and provides the meeting schedule comprising the selected date, time, and meeting location, and the selected conferencing mechanism as a meeting invite option to the user.

Abstract: Computer-implemented functionality is described herein for assisting a user in interacting with an environment. In one implementation, the functionality operates by: determining that a particular user is within a prescribed proximity to an electronic sign, or will be in prescribed proximity to the electronic sign, based on sensor information provided by one or more sensors within the environment; determining an identity of the user; determining at least one destination of the user based at least on calendar information; providing directions to the destination(s), to provide unfiltered direction information; optionally filtering the unfiltered direction information with respect to restriction information (e.g., privacy information, security information, etc.), to produce filtered direction information; composing sign information based on the filtered direction information; and sending the sign information to the electronic sign for presentation by the sign.

Abstract: Computer-implemented functionality is described herein for assisting a user in interacting with an environment. In one implementation, the functionality operates by: determining that a particular user is within a prescribed proximity to an electronic sign, or will be in prescribed proximity to the electronic sign, based on sensor information provided by one or more sensors within the environment; determining an identity of the user; determining at least one destination of the user based at least on calendar information; providing directions to the destination(s), to provide unfiltered direction information; optionally filtering the unfiltered direction information with respect to restriction information (e.g., privacy information, security information, etc.), to produce filtered direction information; composing sign information based on the filtered direction information; and sending the sign information to the electronic sign for presentation by the sign.

Abstract: A technique is described for efficiently detecting a wireless beacon signal emitted from a beacon-emitting mechanism, and thereby reducing consumption of power. The technique operates by selectively increasing detection activity when a detection event is likely to occur, and decreasing it otherwise. The technique leverages calendar information as one factor in determining when a detection event is likely to occur. The technique can also vary the detection activity based on location information (identifying the location of a user) and/or motion information (describing the motion of the user).

Abstract: A receiver receives a request to schedule a meeting from a user and in response, prompts the user to provide meeting information including time information and attendee information for scheduling the meeting. A meeting scheduler identifies potential dates and potential times based on the meeting information. The meeting scheduler further detects locations of the attendees based on the potential dates and identifies potential meeting locations based on attendees' location. The meeting scheduler also computes date scores for the potential dates, time scores for the potential times, and location scores for the meeting locations to select a date, a time, and a meeting location based on scores to determine a meeting schedule. The meeting scheduler further selects a conferencing mechanism for the meeting and provides the meeting schedule comprising the selected date, time, and meeting location, and the selected conferencing mechanism as a meeting invite option to the user.

Abstract: A remote control service on a mobile device interrogates a program on another computing device to obtain metadata describing the structure of information being displayed on the computing device. The remote control service then calculates a different data structure that is used to display a subset of the data on the display screen of the mobile device.

Abstract: A technique is described for efficiently detecting a wireless beacon signal emitted from a beacon-emitting mechanism, and thereby reducing consumption of power. The technique operates by selectively increasing detection activity when a detection event is likely to occur, and decreasing it otherwise. The technique leverages calendar information as one factor in determining when a detection event is likely to occur. The technique can also vary the detection activity based on location information (identifying the location of a user) and/or motion information (describing the motion of the user).

Abstract: Computer-implemented functionality is described herein for assisting a user in interacting with an environment. In one implementation, the functionality operates by: determining that a particular user is within a prescribed proximity to an electronic sign, or will be in prescribed proximity to the electronic sign, based on sensor information provided by one or more sensors within the environment; determining an identity of the user; determining at least one destination of the user based at least on calendar information; providing directions to the destination(s), to provide unfiltered direction information; optionally filtering the unfiltered direction information with respect to restriction information (e.g., privacy information, security information, etc.), to produce filtered direction information; composing sign information based on the filtered direction information; and sending the sign information to the electronic sign for presentation by the sign.

Abstract: A remote control service on a mobile device interrogates a program on another computing device to obtain metadata describing the structure of information being displayed on the computing device. The remote control service then calculates a different data structure that is used to display a subset of the data on the display screen of the mobile device.

Abstract: A head testing apparatus is provided for testing an output of a magnetic data recording head. The apparatus includes first and second tester input terminals for coupling to the head, first and second input stages and an AC-coupled differential amplifier. The first input stage has a first buffer input, which is coupled to the first tester input terminal, a first buffer output and a plurality of parallel-connected buffer amplifiers coupled between the first buffer input and the first buffer output. The second input stage has a second buffer input, which is coupled to the second tester input terminal, a second buffer output and a plurality of parallel-connected buffer amplifiers coupled between the second buffer input and the second buffer output. The AC-coupled differential amplifier has first and second amplefier inputs coupled to the first and second buffer outputs through first and second capacitors, respectively, and has a measurement output.

Abstract: A balanced bi-directional current source is provided, which includes first and second current output terminals, a current control circuit, first and second amplifiers and first and second sense impedances. The current control circuit has a reference input, a feedback input, and a control output, which is based on the reference input and the feedback input. The first amplifier has a first amplifier input, which is coupled to the control output, and a first amplified output. The second amplifier has a second amplifier input, which is coupled to the control output, and a second amplified output, which is inverted relative to the first amplified output. The first sense impedance is coupled in series between the first amplified output and the first current output terminal and has a feedback output which is coupled to the feedback input. The second sense impedance is matched with the first impedance and is coupled in series between the second amplified output and the second current output terminal.

Abstract: A balanced bi-directional current source is provided, which includes first and second current output terminals, a current control circuit, first and second amplifiers and first and second sense impedances. The current control circuit has a reference input, a feedback input, and a control output, which is based on the reference input and the feedback input. The first amplifier has a first amplifier input, which is coupled to the control output, and a first amplified output. The second amplifier has a second amplifier input, which is coupled to the control output, and a second amplified output, which is inverted relative to the first amplified output. The first sense impedance is coupled in series between the first amplified output and the first current output terminal and has a feedback output which is coupled to the feedback input. The second sense impedance is matched with the first impedance and is coupled in series between the second amplified output and the second current output terminal.

Abstract: A voltage measurement circuit is provided, which is has an AC-coupled differential amplifier coupled to first and second input terminals for measuring a voltage across the first and second input terminals. The AC-coupled differential amplifier blocks a DC component of the voltage and presenting a low input bias current to the first and second input terminals while isolating the first and second input terminals from charge stored in capacitances in the AC-coupled differential amplifier.

Abstract: A head testing apparatus is provided for testing a magnetic data recording head. The apparatus includes a test volume adapted to receive the magnetic data recording head and a magnetic field source positioned to generate a magnetic field within the test volume. A Hall sensor is positioned relative to the test volume and has bias current input terminals, voltage output terminals, an operating temperature and an impedance between the bias current input terminals, which varies with the operating temperature. A bias current source is electrically coupled to the bias current input terminals and is adapted to provide a bias current, which is modulated based on the impedance of the Hall sensor.

Abstract: An improved cover assembly for an object disposed therein, such as a guy wire, is disclosed and includes a tube having inner and outer surfaces. Also, the tube is constructed with a tube hole formed adjacent an end thereof. Disposed within the tube is means for clamping the guy wire. The clamping means includes an actuating means. Coupled to the clamping means and extending outwardly through the hole in the tube, is means for maintaining the clamping means in a preselected position until it is desired to rotate the bolt to tighten or loosen the clamp. Also disclosed is a cover assembly including a plurality of clamping means and maintaining means.