Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

Abstract: A batch process produces unitary grains of propellant material. A constituent mixture of the material is prepared by mixing constituents while heating to at least a predetermined pouring temperature within a permissible temperature range. The constituent mixture is poured into a mold, while vibrating it to avoid voids or interfaces within the material, to cast a block of propellant. The cast block is cured for a predetermined period resulting in a cured, cast block of semirigid yet plasticly deformable material. A hydraulic press with a ram carrying a tubular cutting die is positioned, as by transferring the mold without its bottom to the press bed, for permitting grains to be cut by movement of the press ram by forcing the cutting die into the cast block to cut from the block a grain of the propellant material, then extracting the grain for further use. The cutting cycle is repeated until the cast block has yielded a satisfactory number of grains.