Abstract: The present disclosure provides methods of treating an ocular disease or disorder. The methods involve direct administration into the eye of a conjugate comprising a biologically active polypeptide and a biocompatible polymer.

Abstract: The present application relates to plasma cells and plasma cell precursors that express a macromolecule, such as a protein, protein mimetic or a peptide and compositions comprising these plasma cells or plasma cell precursors. The application further relates to methods of using and making the plasma cells and plasma cell precursors that express the macromolecule. Methods of treatment comprising administering the plasma cells or plasma cell precursors are also contemplated.

Abstract: Hemp-based absorbent articles are disclosed. The absorbent article can be a tampon or pad for feminine hygiene. The absorbent article can be flushable or compostable. In one example, the absorbent article is a flushable tampon for feminine hygiene having a nonwoven material comprising hemp with a hemp fiber length in a range of about 8 mm to about 15 mm. The nonwoven material can include an absorbent ribbon, a string, and an overwrap.

Abstract: A severed nerve may be surgically rejoined and severed axons fused via sequential administrations of solutions. The solutions may include a priming solution comprising methylene blue in a Ca2+-free saline solution, a fusion solution comprising about 50% (w/w) PEG, and a sealing solution comprising Ca2+-containing saline. The PEG fusion solution may be applied in a nerve treatment device configured to isolate the injured segment of the nerve. The device may include a containment chamber for creating a fluid containment field around the anastomosis. The device may have slits, slots, and/or apertures in opposing endwalls of the device designed to receive the nerve. The device may have an open bath configuration or may include separable lower and upper bodies to create a closed bath configuration. The device may include one or more fluid ports in fluid communication with the containment chamber for introducing and/or removing fluid.

Abstract: A severed nerve may be surgically rejoined and severed axons fused via sequential administrations of solutions. The solutions may include a priming solution comprising methylene blue in a Ca2+-free saline solution, a fusion solution comprising about 50% (w/w) PEG, and a sealing solution comprising Ca2+-containing saline. The PEG fusion solution may be applied in a nerve treatment device configured to isolate the injured segment of the nerve. The device may include a containment chamber for creating a fluid containment field around the anastomosis. The device may have slits, slots, and/or apertures in opposing endwalls of the device designed to receive the nerve. The device may have an open bath configuration or may include separable lower and upper bodies to create a closed bath configuration. The device may include one or more fluid ports in fluid communication with the containment chamber for introducing and/or removing fluid.

Abstract: The present disclosure is directed to a wiping product well suited to absorbing a solvent and releasing the solvent onto an adjacent surface. The wiping product can also be constructed so as to have excellent abrasion resistance. The wiping product can be used in numerous applications and is particularly well suited for wiping unfinished surfaces, such as metal surfaces and composite surfaces for removing contaminants, such as oil and grease. The wiping product is made from a hydroentangled and thermally bonded web containing staple fibers and conjugated fibers.

Abstract: A severed nerve may be surgically rejoined and severed axons fused via sequential administrations of solutions. The solutions may include a priming solution comprising methylene blue in a Ca2+-free saline solution, a fusion solution comprising about 50% (w/w) PEG, and a sealing solution comprising Ca2+-containing saline. The PEG fusion solution may be applied in a nerve treatment device configured to isolate the injured segment of the nerve. The device may include a containment chamber for creating a fluid containment field around the anastomosis. The device may have slits, slots, and/or apertures in opposing endwalls of the device designed to receive the nerve. The device may have an open bath configuration or may include separable lower and upper bodies to create a closed bath configuration. The device may include one or more fluid ports in fluid communication with the containment chamber for introducing and/or removing fluid.

Abstract: The present invention relates to a nonwoven acquisition distribution layer comprising: a) layered carded webs wherein the first layer comprises a carded web with high denier fibers wherein the denier is greater than about 5 d and a second layer comprising a carded web with low denier fibers wherein the denier is less than about 5 d and is positioned just below and in direct contact with the first layer; and b) a deflection layer comprising a fibrous nonwoven web wherein the fibrous nonwoven web has at least one component comprising meltblown, said meltblown having a basis weight of from about 15 gsm to about 50 gsm and having an air permeability of from about 45 ft3/min/ft2 to about 350 ft3/min/ft2; and wherein the deflection layer is positioned just below and in direct contact with said second layer of said layered carded web.

Abstract: The present invention relates to a nonwoven acquisition distribution layer comprising: a) layered carded webs wherein the first layer comprises a carded web with high denier fibers wherein the denier is greater than about 5 d and a second layer comprising a carded web with low denier fibers wherein the denier is less than about 5 d and is positioned just below and in direct contact with the first layer; and b) a deflection layer comprising a fibrous nonwoven web wherein the fibrous nonwoven web has at least one component comprising meltblown, said meltblown having a basis weight of from about 15 gsm to about 50 gsm and having an air permeability of from about 45 ft3/min/ft2 to about 350 ft3/min/ft2; and wherein the deflection layer is positioned just below and in direct contact with said second layer of said layered carded web.

Abstract: A resilient coform nonwoven web that contains a matrix of meltblown fibers and an absorbent material is provided. The meltblown fibers may constitute from 45 wt % to about 99 wt % of the web and the absorbent material may constitute from about 1 wt % to about 55 wt % of the web. The meltblown fibers may be formed from a thermoplastic composition that contains at least one propylene/?-olefin copolymer having a propylene content of from about 60 mole % to about 99.5 mole % and an ?-olefin content of from about 0.5 mole % to about 40 mole %. The copolymer may have a density of from about 0.86 to about 0.90 grams per cubic centimeter and the thermoplastic composition may have a melt flow rate of from about 200 to about 6000 grams per 10 minutes, determined at 230° C. in accordance with ASTM Test Method D1238-E. The coform web may be imparted with a three-dimensional texture by, for example, using a three-dimensional forming surface.

Abstract: The present disclosure is directed to a wiping product well suited to absorbing a solvent and releasing the solvent onto an adjacent surface. The wiping product can also be constructed so as to have excellent abrasion resistance. The wiping product can be used in numerous applications and is particularly well suited for wiping unfinished surfaces, such as metal surfaces and composite surfaces for removing contaminants, such as oil and grease. The wiping product is made from a hydroentangled and thermally bonded web containing staple fibers and conjugated fibers.

Abstract: Disclosed herein is a cellulosic textile filament made from microfibrillar cellulose fibers and a thickening agent as well as the precursor dope for forming such filaments, nonwoven webs made from such cellulosic textile filaments and the process for forming such filaments and nonwoven webs including such filaments. One of the advantages of these filaments is the eco-sensitive way in which they are made as they utilize a water-based dope that does not require any chemical solvents unlike other processes such as those used to make Lyocell fibers. In addition, the process does not involve any washing or extraction steps and it employs a cellulosic fiber source that is broadly based and renewable.

Abstract: A resilient coform nonwoven web that contains a matrix of meltblown fibers and an absorbent material is provided. The meltblown fibers may constitute from 45 wt % to about 99 wt % of the web and the absorbent material may constitute from about 1 wt % to about 55 wt % of the web. The meltblown fibers may be formed from a thermoplastic composition that contains at least one propylene/?-olefin copolymer having a propylene content of from about 60 mole % to about 99.5 mole % and an ?-olefin content of from about 0.5 mole % to about 40 mole %. The copolymer may have a density of from about 0.86 to about 0.90 grams per cubic centimeter and the thermoplastic composition may have a melt flow rate of from about 200 to about 6000 grams per 10 minutes, determined at 230° C. in accordance with ASTM Test Method D1238-E. The coform web may be imparted with a three-dimensional texture by, for example, using a three-dimensional forming surface.

Abstract: A flexible coform nonwoven web that contains a matrix of meltblown fibers and an absorbent material is provided. The meltblown fibers may constitute from about 2 wt % to about 40 wt % of the coform web. The absorbent material may constitute from about 60 wt % to about 98 wt % of the coform web. The Cup Crush Energy/Thickness ratio of the nonwoven structure is desirably less than about 600. The coform web may be imparted with a three-dimensional texture by, for example, using a three-dimensional forming surface. The coform web is suitable for forming absorbent articles such as wipers and personal care absorbent products.

Abstract: Disclosed herein is a cellulosic textile filament made from microfibrillar cellulose fibers and a thickening agent as well as the precursor dope for forming such filaments, nonwoven webs made from such cellulosic textile filaments and the process for forming such filaments and nonwoven webs including such filaments. One of the advantages of these filaments is the eco-sensitive way in which they are made as they utilize a water-based dope that does not require any chemical solvents unlike other processes such as those used to make Lyocell fibers. In addition, the process does not involve any washing or extraction steps and it employs a cellulosic fiber source that is broadly based and renewable.

Abstract: The present invention provides a soft, bulky, and absorbent hydroentangled nonwoven including regenerated cellulose fibers and staple or wood pulp fibers and a method of making the same that includes the steps of a) placing regenerated cellulose fibers on a forming surface; b) depositing staple or wood pulp fibers on the regenerated cellulose fibers; c) hydroentangling the regenerated cellulose fibers and the staple or wood pulp fibers together to form a hydroentangled composite; d) drying the hydroentangled composite; then, e) creping the hydroentangled composite with a frothed creping solution or dispersion.

Abstract: A coform nonwoven web that contains a matrix of meltblown fibers and an absorbent material is provided. The meltblown fibers are formed from a thermoplastic composition that contains at least one propylene/?-olefin copolymer of a certain monomer content, density, melt flow rate, etc. The selection of a specific type of propylene/?-olefin copolymer provides the resulting composition with improved thermal properties for forming a coform web. For example, the thermoplastic composition crystallizes at a relatively slow rate, thereby allowing the fibers to remain slightly tacky during formation. This tackiness may provide a variety of benefits, such as enhancing the ability of the meltblown fibers to adhere to the absorbent material during formation of the coform web. In certain embodiments, the coform web may also be imparted with texture using a three-dimensional forming surface.

Abstract: A textured coform nonwoven web is provided that includes a matrix of meltblown fibers and an absorbent material. The coform nonwoven web is textured in that it includes first offsets that extend from the coform web. Further, the first offsets are themselves textured in that upper surfaces of the first offsets include a foundation texture. A continuous region from which the offsets extend further includes a secondary texture that may or may not be different from the foundation texture. The offsets may further include side walls that include a side wall texture. The side wall texture may or may not be different than both the foundation texture and the secondary texture.

Abstract: Disclosed is an absorbent article including a temperature change member. The temperature change member includes a matrix of fibers and temperature change material intermixed within the matrix of fibers.

Abstract: An elastic laminate that contains a nonwoven web bonded to an elastic layer is provided. The elastic layer contains one or more elastomeric polymers that are generally polar in nature, such as polyurethanes. To the contrary, the nonwoven web is formed from a material that is non-polar in nature. Nevertheless, one or more surfaces of the nonwoven web are fluorinated so that the resulting surface tension is increased. In this manner, the present inventors have discovered that, despite the difference in polarity between the layers, good attachment may be achieved without necessarily requiring an adhesive. Not only will such layers remained attached, but the functionality of the resulting laminate is also not adversely affected.