Patents by Inventor David M. Kleinman
David M. Kleinman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9452156Abstract: Described herein are formulations and methods for treating, inhibiting, preventing, delaying onset, or causing regression of a disease or condition relating to vascular permeability.Type: GrantFiled: April 30, 2013Date of Patent: September 27, 2016Assignee: SANTEN PHARMACEUTICAL CO., LTD.Inventors: David M. Kleinman, Thierry Nivaggioli, Mary E. Gerritsen, David A. Weber
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Publication number: 20150265581Abstract: Described herein are formulations and methods for treating, inhibiting, preventing, delaying onset, or causing regression of a disease or condition relating to vascular permeability.Type: ApplicationFiled: April 30, 2013Publication date: September 24, 2015Inventors: David M. KLEINMAN, Thierry NIVAGGIOLI, Mary E. GERRITSEN, David A. WEBER
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Publication number: 20140267668Abstract: A portable hand-held ocular fundus camera system for imaging the fundus of the eye is disclosed. The camera system is comprised of a camera housing, one or more groups of lens in an internal cavity of the housing, a front group of lenses at the front end of the internal cavity, a contact member to contact at least a portion of the cornea, a light source configured to direct light from locations inside the camera through an annulus near the periphery of the front lens group, so that the light enters the eye through an annulus at the periphery of the pupil of the eye during contact with the cornea. Light from the light source that is reflected off of the fundus that passes through the center portion of the pupil of the eye is imaged onto an imager configured to acquire a sequence of images while an actuator coupled to the imager continuously varies the location of the imager along the optical axis of the camera.Type: ApplicationFiled: March 14, 2014Publication date: September 18, 2014Inventors: Filipp V. IGNATOVICH, Donald S. GIBSON, Michael A. MARCUS, David M. KLEINMAN
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Patent number: 8836778Abstract: A portable hand-held camera for imaging the fundus of an eye, the camera comprising a housing comprising an internal cavity terminating at a forward housing end, a forward lens, and a light source configured to direct light from locations distributed around the perimeter of the forward lens forwardly out of the housing end. In other embodiment, a portable hand-held camera for imaging the fundus of an eye includes optics configured to focus light reflected back from the fundus onto an image receptor, with the optics being capable of varying the field of view among differing portions of the fundus. Methods to ensure unique image identification and storage are described.Type: GrantFiled: December 4, 2010Date of Patent: September 16, 2014Assignee: Lumetrics, Inc.Inventors: Filipp V. Ignatovich, David M. Kleinman, Christopher T. Cotton, Todd Blalock
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Patent number: 8802075Abstract: The invention contemplates a copolymer which is a graft or block copolymer useful to change wettability and surface characteristics of biological surfaces. Methods for use of these formulations and coatings to change wettability and sterically stabilize, and lubricate biological surfaces in a subject, for example, in the treatment of dry eye syndrome, and to prevent adherence of unwanted proteins, for example in the treatment of contact lens intolerance, are provided.Type: GrantFiled: February 18, 2010Date of Patent: August 12, 2014Assignee: Eyeon Particle Sciences LLCInventors: Eugene R. Cooper, David M. Kleinman, Andrew Loxley, Mark Mitchnick
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Patent number: 8486960Abstract: Described herein are formulations and methods for treating, inhibiting, preventing, delaying onset, or causing regression of a disease or condition relating to vascular permeability.Type: GrantFiled: June 21, 2012Date of Patent: July 16, 2013Assignee: Santen Pharmaceutical Co., Ltd.Inventors: David M. Kleinman, Thierry Nivaggioli, Mary E. Gerritsen, David A. Weber
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Publication number: 20120329759Abstract: Described herein are formulations and methods for treating, inhibiting, preventing, delaying onset, or causing regression of a disease or condition relating to vascular permeability.Type: ApplicationFiled: June 21, 2012Publication date: December 27, 2012Applicant: Santen Pharmaceutical Co., Ltd.Inventors: David M. KLEINMAN, Thierry NIVAGGIOLI, Mary E. GERRITSEN, David A. WEBER
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Publication number: 20120287255Abstract: A portable hand-held camera for imaging the fundus of an eye, the camera comprising a housing comprising an internal cavity terminating at a forward housing end, a forward lens, and a light source configured to direct light from locations distributed around the perimeter of the forward lens forwardly out of the housing end. In other embodiment, a portable hand-held camera for imaging the fundus of an eye includes optics configured to focus light reflected back from the fundus onto an image receptor, with the optics being capable of varying the field of view among differing portions of the fundus. Methods to ensure unique image identification and storage are described.Type: ApplicationFiled: December 4, 2010Publication date: November 15, 2012Applicant: LUMETRICS, INC.Inventors: Filipp V. Ignatovich, David M. Kleinman, Christopher T. Cotton, Todd Blalock
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Patent number: 8222271Abstract: Described herein are formulations and methods for treating, inhibiting, preventing, delaying onset, or causing regression of a disease or condition relating to vascular permeability.Type: GrantFiled: March 23, 2007Date of Patent: July 17, 2012Assignee: Santen Pharmaceutical Co., Ltd.Inventors: David M. Kleinman, Thierry Nivaggioli, Mary E. Gerritsen, David A. Weber
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Publication number: 20120034279Abstract: Diseases associated with the tissues in the posterior segment of the eye can be effectively treated by administering therapeutic agents transsclerally to those tissues. Compositions, devices, and methods for delivering therapeutic agents so that they cross the sclera and reach these tissues include injecting solutions or suspensions adjacent to or within the sclera and implanting solid structures containing the therapeutic agent adjacent to or within the sclera. These methods may be used for administering rapamycin or related compounds to treat choroidal neovascularization associated with age-related macular degeneration.Type: ApplicationFiled: October 21, 2011Publication date: February 9, 2012Applicant: Santen Pharmaceutical Co., Ltd.Inventors: Eugene R. COOPER, David M. Kleinman, Thierry Nivaggioli, Philippe JM Dor, Sreenivasu Mudumba
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Publication number: 20110177169Abstract: The eye is effectively treated by providing it with formulations including uncoated cationically charged microparticles of reversed cubic phase or reversed hexagonal phase material. The treatment methods are effective; for a variety of diseases and conditions including dry eye. The structure, charge and components of the microparticles in dispersion, with or without an active ingredient, provide mucoadhesion, layering, protection and prolonged duration of ophthalmic action.Type: ApplicationFiled: July 9, 2010Publication date: July 21, 2011Inventors: David Anderson, Vince Conklin, Benjamin Cameransi, David M. Kleinman, Eugene R. Cooper
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Publication number: 20100226963Abstract: The invention contemplates a copolymer which is a graft or block copolymer useful to change wettability and surface characteristics of biological surfaces. Methods for use of these formulations and coatings to change wettability and sterically stabilize, and lubricate biological surfaces in a subject, for example, in the treatment of dry eye syndrome, and to prevent adherence of unwanted proteins, for example in the treatment of contact lens intolerance, are provided.Type: ApplicationFiled: February 18, 2010Publication date: September 9, 2010Applicant: Eyeon Particle Sciences LLCInventors: Eugene R. Cooper, David M. Kleinman, Andrew Loxley, Mark Mitchnick
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Publication number: 20100100194Abstract: A method and related apparatus to treat cataract where the cataractous lens is pierced and the resulting opening is mechanically maintained using a lens system device such as a pinhole device, expandable tubular lens, a stent or similar small diameter device, some of which are capable of supporting a secondary intraocular lens. The resulting passageway or lumen created in the cataractous lens allows visible light to better reach the retina, thus improving vision. This lens system device that can be placed into an in situ cataract provides for a much simpler surgical technique and reduces related pre and post operative procedures and potential complications. The method does not involve removal of the cataractous lens and replacement with an intraocular lens, but rather involves the addition of a device that maintains an improved passageway for light through the cataractous lens, reducing scatter and improving image formation on the retina. Intraocular lenses may also be used in concert with this invention.Type: ApplicationFiled: October 18, 2009Publication date: April 22, 2010Inventor: David M. Kleinman
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Publication number: 20090324689Abstract: Diseases associated with the tissues in the posterior segment of the eye can be effectively treated by administering therapeutic agents transsclerally to those tissues. Compositions, devices, and methods for delivering therapeutic agents so that they cross the sclera and reach these tissues include injecting solutions or suspensions adjacent to or within the sclera and implanting solid structures containing the therapeutic agent adjacent to or within the sclera. These methods may be used for administering rapamycin or related compounds to treat choroidal neovascularization associated with age-related macular degeneration.Type: ApplicationFiled: August 13, 2009Publication date: December 31, 2009Applicant: MacuSight, Inc.Inventors: Eugene R. COOPER, David M. Kleinman, Thierry Nivaggioli, Philippe J. M. Dor, Sreenivasu Mudumba
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Publication number: 20090324687Abstract: Diseases associated with the tissues in the posterior segment of the eye can be effectively treated by administering therapeutic agents transsclerally to those tissues. Compositions, devices, and methods for delivering therapeutic agents so that they cross the sclera and reach these tissues include injecting solutions or suspensions adjacent to or within the sclera and implanting solid structures containing the therapeutic agent adjacent to or within the sclera. These methods may be used for administering rapamycin or related compounds to treat choroidal neovascularization associated with age-related macular degeneration.Type: ApplicationFiled: July 31, 2009Publication date: December 31, 2009Applicant: MacuSight, Inc.Inventors: Eugene R. Cooper, David M. Kleinman, Thierry Nivaggioli, Philippe J. M. Dor, Sreenivasu Mudumba
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Publication number: 20090324690Abstract: Diseases associated with the tissues in the posterior segment of the eye can be effectively treated by administering therapeutic agents transsclerally to those tissues. Compositions, devices, and methods for delivering therapeutic agents so that they cross the sclera and reach these tissues include injecting solutions or suspensions adjacent to or within the sclera and implanting solid structures containing the therapeutic agent adjacent to or within the sclera. These methods may be used for administering rapamycin or related compounds to treat choroidal neovascularization associated with age-related macular degeneration.Type: ApplicationFiled: August 14, 2009Publication date: December 31, 2009Applicant: MacuSight, Inc.Inventors: Eugene R. Cooper, David M. Kleinman, Thierry Nivaggioli, Philippe J. M. Dor, Sreenivasu Mudumba
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Publication number: 20090324686Abstract: Diseases associated with the tissues in the posterior segment of the eye can be effectively treated by administering therapeutic agents transsclerally to those tissues. Compositions, devices, and methods for delivering therapeutic agents so that they cross the sclera and reach these tissues include injecting solutions or suspensions adjacent to or within the sclera and implanting solid structures containing the therapeutic agent adjacent to or within the sclera. These methods may be used for administering rapamycin or related compounds to treat choroidal neovascularization associated with age-related macular degeneration.Type: ApplicationFiled: July 29, 2009Publication date: December 31, 2009Applicant: MacuSight, Inc.Inventors: Eugene R. Cooper, David M. Kleinman, Thierry Nivaggioli, Philippe J.M. Dor, Sreenivasu Mudumba
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Patent number: 7585517Abstract: Diseases associated with the tissues in the posterior segment of the eye can be effectively treated by administering therapeutic agents transsclerally to those tissues. Compositions, devices, and methods for delivering therapeutic agents so that they cross the sclera and reach these tissues include injecting solutions or suspensions adjacent to or within the sclera and implanting solid structures containing the therapeutic agent adjacent to or within the sclera. These methods may be used for administering rapamycin or related compounds to treat choroidal neovascularization associated with age-related macular degeneration.Type: GrantFiled: September 20, 2004Date of Patent: September 8, 2009Assignee: Macusight, Inc.Inventors: Eugene R. Cooper, David M. Kleinman, Thierry Nivaggioli, Philippe J M Dor, Sreenivasu Mudumba