Patents by Inventor David M. Lin

David M. Lin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220016629
    Abstract: A microfluidic chip for on-chip detection of the presence or absence of a target nucleic acid region in an isolated nucleic acid sample is disclosed. The microfluidic chip includes a nucleic acid entanglement array, an isolated nucleic acid sample immobilized in the nucleic acid entanglement array, and at least one probe specific to a target nucleic acid region. Systems and methods of using the microfluidic chip are disclosed.
    Type: Application
    Filed: November 29, 2019
    Publication date: January 20, 2022
    Applicant: CORNELL UNIVERSITY
    Inventors: Harold G. CRAIGHEAD, Harvey C. TIAN, David M. LIN, Adam J. BISOGNI
  • Publication number: 20220010360
    Abstract: A method for isolating one or more distinct analyte component from a cell sample is disclosed, as well as processes for testing and analyzing the distinct analyte components. The distinct analyte components include: (i) a total protein fraction; (ii) a plasma membrane protein fraction; (iii) a total RNA fraction; (iv) a cytosolic RNA fraction; (v) a cytosolic protein fraction; (vi) a nuclear RNA fraction; (vii) a nuclear protein fraction; (viii) a chromatin fraction comprising genomic DNA (gDNA); (ix) a gDNA markers fraction. This method involves the use of microfluidic device having a cell capture component and a nucleic acid entanglement component, where the cell capture component includes a cell capture array having a plurality of cell capture micropillars, where the nucleic acid entanglement component includes a nucleic acid entanglement array having a plurality of nucleic acid entanglement micropillars, and where the microfluidic device operates under continuous flow conditions.
    Type: Application
    Filed: November 29, 2019
    Publication date: January 13, 2022
    Applicant: CORNELL UNIVERSITY
    Inventors: Harold G. CRAIGHEAD, Harvey C. TIAN, David M. LIN, Adam J. BISOGNI
  • Patent number: 9493022
    Abstract: An apparatus for forming an array of deposits on a substrate is disclosed. The apparatus may include a stencil capable of releasable attached to the substrate and having an array of openings and at least one alignment mark. The apparatus may further include a high throughput deposition printer aligned with the stencil to form an array of deposits on the substrate. The array of deposits may be aligned with the array of openings through the at least one alignment mark and an optional alignment device. Methods of manufacturing the stencil and using it to generate multiplexed or combinatorial arrays are also disclosed.
    Type: Grant
    Filed: August 5, 2010
    Date of Patent: November 15, 2016
    Assignee: Cornell University
    Inventors: Christine P. Tan, David M. Lin, Harold G. Craighead
  • Patent number: 9184975
    Abstract: An imbalance compensation system includes a receiver, a first path and a second path electrically coupled to the receiver, and a 90 degree hybrid coupler electrically connected to the second path, wherein the first path is configured to convey an in-phase (I) signal and the second path is configured to convey a quadrature phase (Q) signal. A processor is configured to perform Finite Impulse Response (FIR) filtering upon the I signal and the Q signal, wherein the processor is configured with an inverse matrix of coefficients corresponding to a frequency-dependent phase imbalance and a frequency-dependent amplitude imbalance between the I signal and the Q signal. The processor is configured to perform FIR filtering to attenuate an image signal down to a system noise floor when the processor simultaneously receives signals in a primary Nyquist region and a conjugate Nyquist region.
    Type: Grant
    Filed: November 20, 2014
    Date of Patent: November 10, 2015
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventors: Lihyeh Liou, David M. Lin
  • Patent number: 8799345
    Abstract: A new approach for applying the multiple signal classification (MUSIC) method for high spectral resolution signal detection is described. The new approach uses a lower order covariance matrix, or, alternately, an autocorrelation matrix, to calculate only the number of eigenvalues and associated eigenvectors actually needed to solve for the number of signals sought.
    Type: Grant
    Filed: August 24, 2009
    Date of Patent: August 5, 2014
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventors: Lihyeh Liou, David M. Lin, James B. Tsui
  • Publication number: 20120180676
    Abstract: An apparatus for forming an array of deposits on a substrate is disclosed. The apparatus may include a stencil capable of releasable attached to the substrate and having an array of openings and at least one alignment mark. The apparatus may further include a high throughput deposition printer aligned with the stencil to form an array of deposits on the substrate. The array of deposits may be aligned with the array of openings through the at least one alignment mark and an optional alignment device. Methods of manufacturing the stencil and using it to generate multiplexed or combinatorial arrays are also disclosed.
    Type: Application
    Filed: August 5, 2010
    Publication date: July 19, 2012
    Applicant: CORNELL UNIVERSITY
    Inventors: Christine P. Tan, David M. Lin, Harold G. Craighead
  • Patent number: 7781378
    Abstract: An array is formed with a protective cover on a substrate. The protective cover is patterned to produce an array of openings to the substrate. Desired material is deposited on the substrate through the openings. The protective cover may then be removed. In one embodiment, the protective cover is a conformal polymer, such as di-para-xylylene. It may be removed by mechanical peeling. The material may be biological material such as DNA. The protective cover may be used to prevent non-specific hybridization in inter-spot regions by performing hybridization with the cover still in place. Hybridization that occurs in such regions between the spots may be removed with removal of the protective cover.
    Type: Grant
    Filed: September 10, 2004
    Date of Patent: August 24, 2010
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Reid N. Orth, David M. Lin, Theodore G. Clark, Yung-Fu Chang, Harold G. Craighead, Jose Manuel Moran-Mirabal
  • Patent number: 7769108
    Abstract: A moderate cost and complexity digital radio receiver system having enhanced instantaneous dynamic range response to the receipt of simultaneous signals and also providing large single signal dynamic range. Multiple signal instantaneous dynamic range improvement is achieved through use of a suppressed zero signal amplitude representation arrangement having a selected number of signal amplitude representing digital bits rather than the larger entire array of digital output bits of the receiver system's analog to digital converter. Digital apparatus for accomplishing the selection of desired high order bits from the analog to digital converter output is also disclosed in detail. Use of a “Monobit” and related simplified Fourier transformation radio receivers as disclosed in identified previous patents of the recited inventors and colleagues is preferred for embodying the digital radio receiver circuit included in a present system.
    Type: Grant
    Filed: December 17, 2004
    Date of Patent: August 3, 2010
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventors: James B. Y. Tsui, David M. Lin, Stephen L. Hary, Nicholas A. Pequignot, Keith M. Graves, John M. Emmert
  • Patent number: 7472152
    Abstract: A Fourier transformation algorithm implementation in which accommodation is provided for the output attenuation occurring when an input signal falls intermediate two terms of the transformation output series in its frequency. Corrected Fourier transformation terms, achieved by combining the magnitudes of attenuated Fourier transformation terms generated by the input signal at Fourier transformation frequencies distant to the input signal frequency, in either a vectorial or a scalar combination, are substituted for an attenuated Fourier transformation term according to the invention. Noise correction of the substitute Fourier transformation terms is also provided. The invention is disclosed through use of a global position system signal example that is subjected to a double Fourier transformation filtering process to enhance the incoming signal to noise ratio. Normally occurring 3.9 decibel attenuations in each Fourier transformation step are reduced to about 0.9 decibel each through use of the invention.
    Type: Grant
    Filed: August 2, 2004
    Date of Patent: December 30, 2008
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventors: James B. Y. Tsui, David M. Lin
  • Patent number: 7440989
    Abstract: A Fourier transformation arrangement usable in an electronic warfare radio receiver for analyzing spectral content of multiple transmitter-sourced brief duration incoming signals for their signal characteristics. The disclosed Fourier transformation arrangement includes approximated Kernel function values disposed in a significant plurality of locations about a real-imaginary coordinate axis origin according to disclosed locating principles. The points are displaced from the origin by magnitudes having real and imaginary component lengths of powers of two commencing with zero. Multiplication involving a power of two component length during a Kernel function utilization are preferably achieved by way of an expanded binary shift multiplication algorithm in lieu of a full fledged digital multiplication algorithm. A group of guiding principles for selecting desirable approximation Kernel function locations is included.
    Type: Grant
    Filed: April 2, 2004
    Date of Patent: October 21, 2008
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventors: James B. Y. Tsui, John M. Emmert, Stephen L. Hary, David M. Lin, Nicholas A. Pequignot, Keith M. Graves
  • Patent number: 7136009
    Abstract: A digital cueing radio receiver system embodied using digital memory in lieu of analog delay lines and thereby avoiding delay line implementation difficulties. The cueing receiver system includes a wideband receiver portion providing an output signal employed for tuning a narrowband receiver portion of the system. Signal delay enabling use of the wideband receiver portion output signals for tuning the narrow band receiver portion selection frequency is provided by a digital memory circuit operating on analog-to-digital converted samples of input signal data of the receiver system. Approximated unity value related mathematical multiplication free Kernel function values are employed in the Fourier transformation. Avoidance of analog delay line-elements in embodying the system is a significant practical advantage of the invention.
    Type: Grant
    Filed: January 31, 2003
    Date of Patent: November 14, 2006
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventors: James B. Y. Tsui, Stephen L. Hary, David M. Lin
  • Patent number: 6975690
    Abstract: A simplified, weak GPS C/A code coherent acquisition method. When performing GPS signal acquisition, the strength of a signal received at a GPS receiver having an outside antenna is generally sufficiently strong such that only 1 ms of data needs to be used in acquisition to find the signal. However, for weak signals received at a GPS receiver, when the antenna is inside a building or vehicle, for example, a long record of data is needed for acquisition. The present invention reduces the calculation burden for GPS signal acquisition for a weak signal.
    Type: Grant
    Filed: August 15, 2001
    Date of Patent: December 13, 2005
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventors: David M. Lin, James B. Y. Tsui
  • Patent number: 6972708
    Abstract: A global position system radio receiver achieved through use of an electronic warfare receiver, and particularly one of the electronic warfare receiver output frequency channels, as a front-end signal processor for the global position system receiver. Electronic warfare receiver channel selection for such usage is described and the attenuating effect of electronic warfare receiver channel center frequency and global position system signal frequency differences are considered. A favorable comparison of present invention and conventional global position system receiver-generated results in processing a global position system signal are included along with control of a sampling frequency characteristic within the electronic warfare receiver in order to align global position system signal frequency and electronic warfare receiver channel location to an electable better degree.
    Type: Grant
    Filed: April 2, 2004
    Date of Patent: December 6, 2005
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventors: James B. Y. Tsui, David M. Lin, Stephen L. Hary
  • Patent number: 6967615
    Abstract: An electronic warfare apparatus for determining the location of for example a ground based source of electromagnetic radiation from a platform such as an aircraft. Location is determined using angle of arrival based vector determinations provided by signal differences detected in the ground based signals arriving at platform antennas. Elimination of angle of arrival errors arising from imprecise knowledge of platform electronic warfare antenna characteristics is a focal point of the invention and is accomplished through precision use of global position system information received via the same electronic warfare antennas. Accurate determination of electronic warfare antenna characteristics prior to consideration of the large distance multiplication factors imposed by aircraft to distant signal source geometry enables accurate distant signal source location using the invention.
    Type: Grant
    Filed: April 2, 2004
    Date of Patent: November 22, 2005
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventors: David M. Lin, James B. Y. Tsui
  • Patent number: 6831596
    Abstract: An arrangement for calibrating the sample frequency determining clock in a global position system receiver using signals received from a Wide Area Augmentation System satellite or other Wide Area Augmentation System signal source. Such Wide Area Augmentation System based clock calibration is free of the Doppler frequency effects impressed on a global position system signal in view of the geo-stationary orbit of a Wide Area Augmentation System satellite. Use of the calibration invention enables correction of the pseudo range determination accomplished with global position system receiver output data. The invention may be considered a new use of signals available from the Wide Area Augmentation System. A noise-considered arrangement for comparing Wide Area Augmentation System and global position system frequencies is included.
    Type: Grant
    Filed: April 4, 2003
    Date of Patent: December 14, 2004
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventors: James B. Y. Tsui, David M. Lin
  • Patent number: 6720917
    Abstract: An improved global positioning system satellite signal acquisition method. The method of the invention reduces the number of operations in the block correlation used in determining Doppler frequency and time of the received GPS C/A or P(Y) codes.
    Type: Grant
    Filed: December 4, 2000
    Date of Patent: April 13, 2004
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventors: David M. Lin, James B. Y. Tsui
  • Publication number: 20030105285
    Abstract: The invention provides methods and compositions relating to odorant receptors, including a general expression cloning methodology which is useful for identifying novel G protein-coupled receptors and a novel family of odorant receptors and related nucleic acids, ligands, agonists and antagonists. These compositions provide a wide variety of applications such as screening for related receptors, and by modulating the function of the disclosed receptors by modulating their expression or contacting them with agonists, antagonist or ligands modulating reproductive/sexual and non-sexual social behaviors mediated via the olfactory system, reproductive physiologies and olfactory system regulated feeding behaviors, migratory behaviors and events such as conception, implantation, estrous and menstruation.
    Type: Application
    Filed: May 17, 2002
    Publication date: June 5, 2003
    Inventors: John Ngai, David J. Speca, David M. Lin, Ehud Y. Isacoff, Andrew H. Dittman, Jinhong Fan
  • Patent number: 6567042
    Abstract: An improved global positioning system satellite signal acquisition method and device. The method and device of the invention reduces the number of operations in the block correlation used in determining Doppler frequency and time of the received GPS C/A and P(Y) codes. Reducing the number of operations in block correlation increases acquisition speed and reduces energy requirements, aspects conducive to commercial and military hand held GPS receivers.
    Type: Grant
    Filed: December 4, 2000
    Date of Patent: May 20, 2003
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventors: David M. Lin, James B. Y. Tsui
  • Patent number: 6410249
    Abstract: The invention provides methods and compositions relating to odorant receptors, including a general expression cloning methodology which is useful for identifying novel G protein-coupled receptors and a novel family of odorant receptors and related nucleic acids, ligands, agonists and antagonists. These compositions provide a wide variety of applications such as screening for related receptors, and by modulating the function of the disclosed receptors by modulating their expression or contacting them with agonists, antagonist or ligands modulating reproductive/sexual and non-sexual social behaviors mediated via the olfactory system, reproductive physiologies and olfactory system regulated feeding behaviors, migratory behaviors and events such as conception, implantation, estrous and menstruation.
    Type: Grant
    Filed: July 19, 2000
    Date of Patent: June 25, 2002
    Assignee: The Regents of the University of California
    Inventors: John Ngai, David J. Speca, David M. Lin, Ehud Y. Isacoff, Andrew H. Dittman, Jinhong Fan
  • Patent number: H2155
    Abstract: An improved apparatus and method for determining the carrier frequency in a biphase coded signal such as the course acquisition code signal in a global position sensing system. The described system may also be used for other purposes. The described system is based on use of the conventional data signal squaring or frequency doubling step to remove biphase coding but performs a series of frequency reducing steps prior to applying the Fourier transformation sequence. The frequency reducing steps include heterodyne mixing and signal averaging. These frequency-reducing steps diminish the speed and capacity requirements imposed on the Fourier transformation sequence and thereby decrease the cost and complexity of the overall system.
    Type: Grant
    Filed: January 28, 2002
    Date of Patent: May 2, 2006
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventors: James B. Y. Tsui, David M. Lin