Patents by Inventor David M. Lubman
David M. Lubman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20110236993Abstract: The present invention relates to pancreatic cancer markers. In particular, the present invention provides methods and compositions for the identification of protein glycosylation patterns associated with pancreatic cancer.Type: ApplicationFiled: September 9, 2009Publication date: September 29, 2011Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: David M. Lubman, Diane M. Simeone, Chen Li
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Publication number: 20090136960Abstract: The present invention relates to methods and compositions for the identification of cancer markers. In particular, the present invention provides methods and compositions for the identification of glycosylated proteins and protein glycosylation patterns. The present invention further provides cancer markers identified using the described methods.Type: ApplicationFiled: March 26, 2007Publication date: May 28, 2009Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: David M. Lubman, Diane M. Simeone, Jia Zhao
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Publication number: 20090099036Abstract: The present invention relates to methods and compositions for screening of glycan structures. In particular, the present invention provides methods and compositions for global profiling of glycoprotein states by utilizing a glycoprotein microarray format. The present invention further provides for methods and compositions of glycoprotein microarray formats for differentiating between different glycosylation states associated with disease states.Type: ApplicationFiled: April 18, 2007Publication date: April 16, 2009Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: David M. Lubman, Tasneem H. Patwa, Jia Zhao
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Publication number: 20080280771Abstract: The present invention relates to automated methods, systems, and apparatuses for protein separation and analysis. In particular, the present invention provides an automated system for the separation, identification, and characterization of the phosphorylation status of protein samples, including the generation and analysis of protein microarrays.Type: ApplicationFiled: June 19, 2007Publication date: November 13, 2008Applicant: Regents of the University of MichiganInventors: David M. Lubman, Arul M. Chinnaiyan, Manoj Pal, Arun Sreekumar, Stephen P. Ethier
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Publication number: 20080153711Abstract: The present invention relates to automated methods, systems, and apparatuses for protein separation and analysis. In particular, the present invention provides an automated system for the separation, identification, and characterization of protein samples. The present invention thus provides improved methods for the separation and analysis of samples containing a plurality of proteins (e.g., cells).Type: ApplicationFiled: June 20, 2007Publication date: June 26, 2008Applicant: Regents of the University of MichiganInventors: David M. Lubman, Arul M. Chinnaiyan, Manoj Pal, Arun Sreekumar, Stephen P. Ethier
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Patent number: 7069151Abstract: The present invention relates to protein separation systems and methods capable of resolving and characterizing large numbers of cellular proteins. In particular, the present invention provides a novel mass mapping system and methods for the differential display of proteins. The present invention further provides novel methods for displaying differential protein expression between two samples. In particular, the present invention provides novel method of mapping differential expression of proteins in non-cancerous, pre-cancerous, and cancerous cells.Type: GrantFiled: February 7, 2001Date of Patent: June 27, 2006Assignee: Regents of the University of MichiganInventors: David M. Lubman, Bathsheba E. Chong, Stephen J. Parus
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Patent number: 6931325Abstract: The present invention relates to multi-phase protein separation methods capable of resolving and characterizing large numbers of cellular proteins, including methods for efficiently facilitating the transfer of protein samples between separation phases. In particular, the present invention provides systems and methods for the generation of multi-dimensional protein maps. The present invention thus provides improved methods for the analysis of samples containing large numbers of proteins.Type: GrantFiled: April 26, 2002Date of Patent: August 16, 2005Assignee: Regents of the University of MichiganInventors: Daniel B. Wall, David M. Lubman, Timothy Barder
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Publication number: 20040214233Abstract: The present invention relates to automated methods, systems, and apparatuses for protein separation and analysis. In particular, the present invention provides an automated system for the separation, identification, and characterization of protein samples. The present invention thus provides improved methods for the separation and analysis of samples containing a plurality of proteins (e.g., cells).Type: ApplicationFiled: January 13, 2004Publication date: October 28, 2004Applicant: The Regents of the University of MichiganInventors: David M. Lubman, Arul M. Chinnaiyan, Arun Sreekumar, Bharathi Laxman, Fang Yan
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Publication number: 20040033591Abstract: The present invention relates to automated methods, systems, and apparatuses for protein separation and analysis. In particular, the present invention provides an automated system for the separation, identification, and characterization of protein samples. The present invention thus provides improved methods for the separation and analysis of samples containing a plurality of proteins (e.g., cells).Type: ApplicationFiled: May 30, 2003Publication date: February 19, 2004Applicant: The Regents of the University of MichiganInventors: David M. Lubman, Stephen J. Parus, Chul S. Yoo
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Publication number: 20040010126Abstract: The present invention relates to multiphase protein separation methods capable of resolving large numbers of cellular proteins. The methods of the present invention provide protein profile maps for imaging and comparing protein expression patterns. The present invention provides alternatives to traditional 2-D gel separation methods for the screening of protein profiles.Type: ApplicationFiled: October 1, 2001Publication date: January 15, 2004Applicant: The Regents of the University of MichiganInventors: David M. Lubman, Timothy J. Barder, Daniel B. Wall, Stephen J. Parus, Maureen T. Kachman, Bathsheba E. Chong, Samir M. Hanash, David E. Misek, Robert Hinderer
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Publication number: 20030064527Abstract: The present invention relates to multi-phase protein separation methods capable of resolving and characterizing large numbers of cellular proteins, including methods for efficiently facilitating the transfer of protein samples between separation phases. In particular, the present invention provides systems and methods for the differential display of protein samples from multiple cell types. The present invention thus provides improved methods for the analysis of multiple samples containing large numbers of proteins.Type: ApplicationFiled: April 26, 2002Publication date: April 3, 2003Applicant: The Regents of the University of MichiganInventors: David M. Lubman, Maureen Kachman, Stephen J. Parus
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Publication number: 20030058239Abstract: The present invention relates to multi-phase protein separation methods capable of resolving and characterizing large numbers of cellular proteins, including methods for efficiently facilitating the transfer of protein samples between separation phases. In particular, the present invention provides systems and methods for the generation of multi-dimensional protein maps. The present invention thus provides improved methods for the analysis of samples containing large numbers of proteins.Type: ApplicationFiled: April 26, 2002Publication date: March 27, 2003Applicant: The Regents of the University of MichiganInventors: Daniel B. Wall, David M. Lubman, Tiimothy Barder
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Publication number: 20020098595Abstract: The present invention relates to multi-phase protein separation methods capable of resolving and characterizing large numbers of cellular proteins, including methods for efficiently facilitating the transfer of protein samples between separation phases. In particular, the present invention provides an automated system for the separation, identification, and characterization of protein samples. The present invention thus provides improved methods for the analysis of samples containing large numbers of proteins.Type: ApplicationFiled: February 7, 2001Publication date: July 25, 2002Applicant: The Regents of the University of MichiganInventors: David M. Lubman, Timothy J. Barder, Daniel B. Wall, Stephen J. Parus, Maureen T. Kachman, Bathsheba E. Chong, Robert C. North, Fang Yan
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Publication number: 20020039747Abstract: The present invention relates to protein separation systems and methods capable of resolving and characterizing large numbers of cellular proteins. In particular, the present invention provides a novel mass mapping system and methods for the differential display of proteins. The present invention further provides novel methods for displaying differential protein expression between two samples. In particular, the present invention provides novel method of mapping differential expression of proteins in non-cancerous, pre-cancerous, and cancerous cells.Type: ApplicationFiled: February 7, 2001Publication date: April 4, 2002Applicant: The Regents of the University of MichiganInventors: David M. Lubman, Bathsheba E. Chong, Stephen J. Parus