Patents by Inventor David M. Markovitz

David M. Markovitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CHIMERIC ANTIGEN RECEPTORS TARGETING ABNORMAL GLYCOBIOLOGY
    Publication number: 20240124548
    Abstract: The disclosure provides a chimeric antigen receptor (CAR) polypeptide having an antigen binding domain comprising an extracellular lectin which specifically binds to glycoproteins expressed on the surface of target cells. Also provided herein are engineered lymphocytes expressing the CAR polypeptide, a nucleic acid molecule encoding the CAR polypeptide, and methods of treating cancer.
    Type: Application
    Filed: August 1, 2023
    Publication date: April 18, 2024
    Inventors: Challice L. Bonifant, Alnawaz Rehemtulla, David M. Markovitz
  • Chimeric antigen receptors targeting abnormal glycobiology
    Patent number: 11760786
    Abstract: The disclosure provides a chimeric antigen receptor (CAR) polypeptide having an antigen binding domain comprising an extracellular lectin which specifically binds to glycoproteins expressed on the surface of target cells. Also provided herein are engineered lymphocytes expressing the CAR polypeptide, a nucleic acid molecule encoding the CAR polypeptide, and methods of treating cancer.
    Type: Grant
    Filed: February 5, 2020
    Date of Patent: September 19, 2023
    Assignee: The Regents of the University of Michigan
    Inventors: Challice L. Bonifant, Alnawaz Rehemtulla, David M. Markovitz
  • CHIMERIC ANTIGEN RECEPTORS TARGETING ABNORMAL GLYCOBIOLOGY
    Publication number: 20200247868
    Abstract: The disclosure provides a chimeric antigen receptor (CAR) polypeptide having an antigen binding domain comprising an extracellular lectin which specifically binds to glycoproteins expressed on the surface of target cells. Also provided herein are engineered lymphocytes expressing the CAR polypeptide, a nucleic acid molecule encoding the CAR polypeptide, and methods of treating cancer.
    Type: Application
    Filed: February 5, 2020
    Publication date: August 6, 2020
    Inventors: Challice L. Bonifant, Alnawaz Rehemtulla, David M. Markovitz
  • Lectins and uses thereof
    Patent number: 10450355
    Abstract: Provided herein are chemical compounds, methods for their discovery, and their therapeutic and research use. Further provided herein are antiviral and antimicrobial lectin compounds and methods of their use.
    Type: Grant
    Filed: September 16, 2015
    Date of Patent: October 22, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: David M. Markovitz, Jeanne A. Stuckey, Daniel M. Boudreaux, Jennifer Meagher, Hashim Al-Hashimi, Loic Salmon
  • LECTINS AND USES THEREOF
    Publication number: 20170291928
    Abstract: Provided herein are chemical compounds, methods for their discovery, and their therapeutic and research use. Further provided herein are antiviral and antimicrobial lectin compounds and methods of their use.
    Type: Application
    Filed: September 16, 2015
    Publication date: October 12, 2017
    Inventors: David M. MARKOVITZ, Jeanne A. STUCKEY, Daniel M. BOUDREAUX, Jennifer MEAGHER, Hashim AL-HASHIMI, Loic SALMON
  • Dek protein compositions and methods of using the same
    Patent number: 8652467
    Abstract: The present invention relates to DEK protein compositions (e.g., antibodies, small molecule inhibitors, siRNAs) and methods of using the same. In particular, the present invention provides compositions and methods for treating autoimmune disease (e.g., juvenile rheumatoid arthritis, lupus, etc.) and for inhibiting inflammation (e.g., associated with autoimmune disease) and cellular chemotaxis (e.g., of neutrophils, NK cells and T cells). The present invention further provides a diagnostic marker (e.g., DEK antigen) for autoimmune disease.
    Type: Grant
    Filed: October 16, 2006
    Date of Patent: February 18, 2014
    Assignee: The Regents of the University of Michigan
    Inventors: David M. Markovitz, Nirit Mor-Vaknin, Michael Khodadoust, Barbara S. Adams
  • Methods of secretory vimentin detection and modulation
    Patent number: 7691582
    Abstract: The present invention relates to methods for screening and modulating the bioavailability of extracellular secretory vimentin. In particular, the present invention provides inhibitors and activators of secretory vimentin including antibodies, small interfering RNAs, and antisense oligonucleotides. The present invention thus provides novel drug targets for enhanced anti-microbial response, and methods of using such modulators to beneficially alter the pathophysiologic effects of secretory vimentin.
    Type: Grant
    Filed: September 24, 2003
    Date of Patent: April 6, 2010
    Assignee: The Regents of the University of Michigan
    Inventors: David M. Markovitz, Nirit Mor-Vaknin, Antonello Punturieri
  • Compositions and methods for detecting cancer and for inhibiting metastasis
    Patent number: 7641902
    Abstract: The present invention relates to compositions and methods for detecting cancer (e.g., prostate cancer) and for inhibiting metastasis (e.g., associated with prostate cancer). In particular, the present invention provides methods of detecting vimentin expression and secretion and for characterizing cancer (e.g., prostate cancer). In addition, the present invention provides methods for inhibiting metastasis (e.g., of prostate cancer) via altering (e.g., inhibiting) vimentin expression and/or activity.
    Type: Grant
    Filed: November 20, 2006
    Date of Patent: January 5, 2010
    Assignee: The Regents of the University of Michigan
    Inventors: David M. Markovitz, Nirit Mor-Vaknin, Evan T. Keller, Christopher L. Hall, Susan M. Hiniker
  • Methods for inhibition of HIV replication using a small molecule inhibitor
    Patent number: 7052676
    Abstract: Methods are provided for inhibiting or suppressing viral replication in an infected host cell. More specifically, methods are provided for inhibiting or suppressing viral replication in an infected host cell by administering compounds that interfere with the binding of C-X-C chemokines to C-X-C chemokine receptors. Such methods are advantageous for treating viral infections such as human immunodefeciency virus infections.
    Type: Grant
    Filed: September 20, 2001
    Date of Patent: May 30, 2006
    Assignee: The Regents of the University of Michigan
    Inventors: David M. Markovitz, Brian R. Lane, Peter J. Polverini, Robert M. Strieter
  • Methods of secretory vimentin detection and modulation
    Publication number: 20040121419
    Abstract: The present invention relates to methods for screening and modulating the bioavailability of extracellular secretory vimentin. In particular, the present invention provides inhibitors and activators of secretory vimentin including antibodies, small interfering RNAs, and antisense oligonucleotides. The present invention thus provides novel drug targets for enhanced anti-microbial response, and methods of using such modulators to beneficially alter the pathophysiologic effects of secretory vimentin.
    Type: Application
    Filed: September 24, 2003
    Publication date: June 24, 2004
    Applicant: The Regents of the University of Michigan
    Inventors: David M. Markovitz, Nirit Mor-Vaknin, Antonello Punturieri
  • Novel methods for inhibition of HIV replication
    Publication number: 20030026802
    Abstract: Methods are provided for inhibiting or suppressing viral replication in an infected host cell. More specifically, methods are provided for inhibiting or suppressing viral replication in an infected host cell by administering compounds that interfere with the binding of C-X-C chemokines to C-X-C chemokine receptors. Such methods are advantageous for treating viral infections such as human immunodefeciency virus infections.
    Type: Application
    Filed: September 20, 2001
    Publication date: February 6, 2003
    Inventors: David M. Markovitz, Brian R. Lane, Peter J. Polverini, Robert M. Strieter
  • Methods of inhibiting host-cell mediated viral replication
    Publication number: 20020137704
    Abstract: Methods are provided for inhibiting or suppressing viral replication in an infected host cell. More specifically, methods are provided for inhibiting or suppressing viral replication in an infected host cell by administering compounds that inhibit cellular protein phosphatase 2A. Such methods are advantageous for treating viral infections such human immunodefeciency virus infections.
    Type: Application
    Filed: June 11, 2001
    Publication date: September 26, 2002
    Inventors: David M. Markovitz, Neil Faulkner, Brian Lane