Abstract: Described herein are antibody constructs comprising a 4- 1BB binding domain and an anti-Folate Receptor a (FRa) antigen- binding domain, wherein the 4-1BB-binding domain and the FR? antigen-binding domain are linked directly or indirectly to a scaffold. The scaffold may be an Fc construct with modifications that reduce its ability to mediate effector function. The antibody constructs are used in the treatment of a subject having cancer.

Abstract: Described herein are antibody constructs comprising a 41-1BB binding domain and an antigen-binding domain that binds to a tumor-associated antigen (TAA), wherein the 4-1BB-binding domain and the TAA antigen-binding domain are linked directly or indirectly to a scaffold. The scaffold may be an Fc construct with modifications that reduce its ability to mediate effector function.

Abstract: Provided herein are tumor-associated antigen (TAA) presentation inducer constructs comprising at least one innate stimulatory receptor (ISR)-binding construct that binds to an ISR expressed on an antigen-presenting cell (APC), and at least one TAA-binding construct that binds directly to a first TAA that is physically associated with tumor cell-derived material (TCDM) comprising one or more other TAAs. The ISR-binding construct and TAA-binding construct are linked to each other, and the TAA presentation inducer construct induces a polyclonal T cell response to the first TAA and to the one or more other TAAs. Also provided are methods of using the TAA presentation inducer constructs, for example, in the treatment of cancer.

Abstract: Multi-specific antigen-binding constructs that target immunotherapeutics are described. The multi-specific antigen-binding constructs comprise a first antigen-binding polypeptide construct that binds to an immunotherapeutic (such as a CAR-T cell or a bispecific T-cell engager), and a second antigen binding polypeptide construct that binds to a tumour-associated antigen. Also described are methods of using the multi-specific antigen-binding constructs to re-direct or enhance the binding of the immunotherapeutic to a tumour cell, and methods of treating patients who have relapsed from or failed treatment with the immunotherapeutic.

Abstract: In one embodiment, a method of detecting centerline of a vessel is provided. The method comprises steps of acquiring a 3D image volume, initializing a centerline, initializing a Kalman filter, predicting a next center point using the Kalman filter, checking validity of the prediction made using the Kalman filter, performing template matching, updating the Kalman filter based on the template matching and repeating the steps of predicting, checking, performing and updating for a predetermined number of times. Methods of automatic vessel segmentation and temporal tracking of the segmented vessel is further described with reference to the method of detecting centerline.

Abstract: A pressure relief valve for a pressurized fluid system in which a compression spring is used to seal a compression shaft in communication with a front bushing having a O-ring seal is provided. The relief valve automatically relieves overpressure conditions and automatically resets to a closed, leak proof after an overpressure event subsides. The compression shaft is also in communication with an indicator pin, which is pushed out of the body of the relief valve during an overpressure event, and remains pushed out until manually reset, thus indicating that an overpressure event has occurred, even after the overpressure event has subsided.

Abstract: In one embodiment, a method of detecting centerline of a vessel is provided. The method comprises steps of acquiring a 3D image volume, initializing a centerline, initializing a Kalman filter, predicting a next center point using the Kalman filter, checking validity of the prediction made using the Kalman filter, performing template matching, updating the Kalman filter based on the template matching and repeating the steps of predicting, checking, performing, and updating for a predetermined number of times. Methods of automatic vessel segmentation and temporal tracking of the segmented vessel is further described with reference to the method of detecting centerline.

Abstract: An infant care system and apparatus includes a horizontal surface to support an infant. A microenvironment region is defined around the horizontal surface by at least one wall. A graphical display is disposed within the microenvironment region. A diagnostic imaging device is at least partially disposed within the microenvironment region to obtain diagnostic images of an infant disposed within the microenvironment region.

Abstract: In one embodiment, a method of detecting centerline of a vessel is provided. The method comprises steps of acquiring a 3D image volume, initializing a centerline, initializing a Kalman filter, predicting a next center point using the Kalman filter, checking validity of the prediction made using the Kalman filter, performing template matching, updating the Kalman filter based on the template matching and repeating the steps of predicting, checking, performing, and updating for a predetermined number of times. Methods of automatic vessel segmentation and temporal tracking of the segmented vessel is further described with reference to the method of detecting centerline.

Abstract: In one embodiment, a method of detecting centerline of a vessel is provided. The method comprises steps of acquiring a 3D image volume, initializing a centerline, initializing a Kalman filter, predicting a next center point using the Kalman filter, checking validity of the prediction made using the Kalman filter, performing template matching, updating the Kalman filter based on the template matching and repeating the steps of predicting, checking, performing and updating for a predetermined number of times. Methods of automatic vessel segmentation and temporal tracking of the segmented vessel is further described with reference to the method of detecting centerline.

Abstract: In one embodiment, a method of detecting centerline of a vessel is provided. The method comprises steps of acquiring a 3D image volume, initializing a centerline, initializing a Kalman filter, predicting a next center point using the Kalman filter, checking validity of the prediction made using the Kalman filter, performing template matching, updating the Kalman filter based on the template matching and repeating the steps of predicting, checking, performing and updating for a predetermined number of times. Methods of automatic vessel segmentation and temporal tracking of the segmented vessel is further described with reference to the method of detecting centerline.

Abstract: An infant care system and apparatus includes a horizontal surface to support an infant. A microenvironment region is defined around the horizontal surface by at least one wall. A graphical display is disposed within the microenvironment region. A diagnostic imaging device is at least partially disposed within the microenvironment region to obtain diagnostic images of an infant disposed within the microenvironment region.

Abstract: In one embodiment, a method of detecting centerline of a vessel is provided. The method comprises steps of acquiring a 3D image volume, initializing a centerline, initializing a Kalman filter, predicting a next center point using the Kalman filter, checking validity of the prediction made using the Kalman filter, performing template matching, updating the Kalman filter based on the template matching and repeating the steps of predicting, checking, performing and updating for a predetermined number of times. Methods of automatic vessel segmentation and temporal tracking of the segmented vessel is further described with reference to the method of detecting centerline.

Abstract: An ultrasonic transducer device comprising: an ultrasonic transducer array micromachined on a substrate; flexible electrical connections connected to the transducer array; and a body of acoustically attenuative material that supports the substrate and the flexible electrical connections. The acoustic backing material may contain additional features, such as tabs or notches, for use in positioning the transducer on fixtures during manufacturing or positioning the transducer within a housing during final assembly. Tabs or other features that are used only during manufacturing may be subsequently removed from the device. The MUT device itself may also be thinned so as to provide flexibility as desired. The backing material is preferably matched in acoustic impedance to the silicon wafer so as to prevent reflection at the interface of any acoustic energy propagating rearward, i.e., in the direction away from the device front surface.

Abstract: A curved sensor device, such as an ultrasonic transducer array, is fabricated from a flat micromachined sensor (such as cMUT or pMUT) array constructed using micromachined electro-mechanical systems (MEMS) techniques. The device comprises: a support structure comprising a spine having a profile that is generally curved and a multiplicity of teeth extending from one side of the curved spine; and a multiplicity of sensors built on the support structure. The spine can be bent forward or backward and attached to a curved front face of a support member, thereby causing the sensors to adopt a curved array.

Abstract: An ultrasound transducer array includes a multiplicity of subelements interconnected by a multiplicity of microelectronic switches, each subelement comprising a respective multiplicity of micromachined ultrasound transducer (MUT) cells. The MUT cells within a particular subelement are hard-wired together. The switches are used to configure the subelements to form multiple concentric annular elements. This design dramatically reduces complexity while enabling focusing in the elevation direction during ultrasonic image data acquisition.

Abstract: RD-28,709 22An ultrasonic transducer device comprising: an ultrasonic transducer array micromachined on a substrate; flexible electrical connections connected to the transducer array; and a body of acoustically attenuative material that supports the substrate and the flexible electrical connections. The acoustic backing material may contain additional features, such as tabs or notches, for use in positioning the transducer on fixtures during manufacturing or positioning the transducer within a housing during final assembly. Tabs or other features that are used only during manufacturing may be subsequently removed from the device. The MUT device itself may also be thinned so as to provide flexibility as desired. The backing material is preferably matched in acoustic impedance to the silicon wafer so as to prevent reflection at the interface of any acoustic energy propagating rearward, i.e., in the direction away from the device front surface.

Abstract: An ultrasound transducer array includes a multiplicity of subelements interconnected by a multiplicity of microelectronic switches, each subelement comprising a respective multiplicity of micromachined ultrasound transducer (MUT) cells. The MUT cells within a particular subelement are hard-wired together. The switches are used to configure the subelements to form multiple concentric annular elements. This design dramatically reduces complexity while enabling focusing in the elevation direction during ultrasonic image data acquisition.

Abstract: RD-28,709 22An ultrasonic transducer device comprising: an ultrasonic transducer array micromachined on a substrate; flexible electrical connections connected to the transducer array; and a body of acoustically attenuative material that supports the substrate and the flexible electrical connections. The acoustic backing material may contain additional features, such as tabs or notches, for use in positioning the transducer on fixtures during manufacturing or positioning the transducer within a housing during final assembly. Tabs or other features that are used only during manufacturing may be subsequently removed from the device. The MUT device itself may also be thinned so as to provide flexibility as desired. The backing material is preferably matched in acoustic impedance to the silicon wafer so as to prevent reflection at the interface of any acoustic energy propagating rearward, i.e., in the direction away from the device front surface.

Abstract: An improved controller for a feed grain conditioning device is characterized by a microcontroller which operates valve actuator relays to control the delivery of moisture to feed grains in order to adjust the grain moisture content to a desired level. A software program controls the operation of the microcontroller. It includes a main program affording user interface and an interrupt program used to calculate the moisture flow necessary to attain the target moisture content in accordance with the moisture content of untreated grain and with the grain mass flow.