Abstract: Provided herein are compounds of formula (II): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein m, n, p, R1, R2, R3, L1, L2, L3, R4, X1, X2, X3, and X4 are as defined herein. Also provided are methods of preparing compounds of formula (II), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided are methods of inhibiting APOL1 and methods of treating an APOL1-mediated disease, disorder, or condition in an individual.

Abstract: Systems, devices, and technical methods of the present disclosure use an edge appliance to facilitate seamless interoperability between a cloud emergency call management system and call-center systems that are situated onsite in an emergency call center. When an emergency call is received from a caller device, the CECMS routes the call to a call taker who may be working remotely on a telecommunication device. The CECMS transmits a duplicate of audio data and other data that is exchanged between the caller device and the telecommunication device during the call to the edge appliance. The edge appliance converts the audio data and the other data into formats that are compatible with the call-center systems and uses a virtual construct that represents the telecommunication device to transmit the converted data to the call-center systems through a network to which both the edge appliance and the call-center systems are connected.

Abstract: The present disclosure relates to a metal recovery process comprising a solvent extraction process. In an exemplary embodiment, the solution extraction system comprises a plant with a first and second circuit. A high-grade pregnant leach solution (“HGPLS”) is provided to the first and second circuit, and a low-grade pregnant leach solution (“LGPLS”) is provided to the second circuit. The first circuit produces a rich electrolyte, which can be forwarded to a primary metal recovery, and a low-grade raffinate, which can be forwarded to a secondary metal recovery process. The second circuit produces a rich electrolyte, which can also be forwarded to the primary metal recovery process. The first and second circuits are in fluid communication with each other.

Abstract: The invention relates to toilet seat, body support, non food surface, disinfecting, cleaning and sanitizing by using a liquid cleaning or sanitizing solution, in general, and to provide a liquid for manual application, and alternatively for spray application; using a brush or disposable dispensing spray apparatus that permits an individual to quickly sanitize, or disinfect the surface, such as a toilet seat, which solution will rapidly dry or evaporate to allow almost immediate body part to body support non food surface contact use.