Abstract: An aircraft wing configuration for a vertical or a short take-off and landing aircraft having a plurality of propeller-blown wings mounted at different longitudinal locations along a fuselage of the vertical take-off and landing aircraft, producing two or more lifting surfaces, fixed at a predetermined acute wing angle greater than 0° and substantially less than 90° relative to a horizontal plane, and having a plurality of flaps disposed behind the wings. The configuration has a plurality of propellers distributed in front of the plurality of wings producing two or more lifting surfaces and mounted such that the wings are externally blown by forced airstreams from the propellers. The propellers produce distributed thrust components, and the plurality of flaps are in the forced airstreams of the propellers when one or more of the flaps is in an extended position.

Abstract: Provided herein are methods of sequencing comprising click chemistry bioconjugation. In some embodiments, target polynucleotide sequences on the same or different molecules are contacted with and hybridize to probes comprising click functional groups. Probes (e.g., reading probes) hybridizing to adaptor sequences adjacent to different sequences of interest (e.g., barcodes to be sequenced) can be hybridized simultaneously in large pools. In some embodiments, the provided methods achieve multiplexing without requiring separate hybridization of probes (e.g., reading probes) for each sequencing-by-ligation cycle, thereby reducing total hybridization time which is typically a most time-consuming step in in situ technologies. In some aspects, the hybridized probes (e.g., reading probes) are clicked onto detectable probes to analyze a sequence of a target polynucleotide in a sequencing-by-ligation fashion.

Abstract: A method of and system for managing access by a plurality of users to a plurality of application programs by maintaining a security database accessible by each of said application programs. In response to an attempted access to one of the application programs by one of the users, the application queries the security database for access information for the user. In response to the query, the security database returns access information to said the application program. The application program limits use of the application program-by the user according to the access information returned from the security database.