Abstract: The present disclosure provides improved compositions for the homology directed repair of the human globin locus for the prevention, treatment, or amelioration of at least one symptom of a hemoglobinopathy.

Abstract: Aspects of the invention described herein concern the incorporation of a FOXP3 cDNA (e.g., full-length human codon-optimized cDNA) into a FOXP3 gene or a non-FOXP3 locus so as to provide constitutive or regulated FOXP3 expression in a primary human CD34+ cells or cells derived from edited CD34+ cells. In some embodiments, guide RNA sequences that are directed to FOXP3, AAVS1, or other candidate loci are used for CRISPR/Cas9-mediated gene regulation, and gene delivery cassettes for HDR based gene-modification are provided.

Abstract: The present application relates to plasma cells and plasma cell precursors that express a macromolecule, such as a protein, protein mimetic or a peptide and compositions comprising these plasma cells or plasma cell precursors. The application further relates to methods of using and making the plasma cells and plasma cell precursors that express the macromolecule. Methods of treatment comprising administering the plasma cells or plasma cell precursors are also contemplated.

Abstract: A lattice-cut potato product is sliced so that the ridges (115) and grooves (122) on one surface of the slices are oriented transversely to the ridges (116) and grooves (124) on the opposite surface of the slices. The sizes and shapes of the ridges and grooves are particularly selected so that each point in the interior of a slice is no greater than a specified distance from an outer surface of the slice. These parameters enable a lattice-cut potato product to consistently achieve a crispy outer surface and a smooth and creamy interior when cooked by baking or microwaving.

Abstract: A lattice-cut potato product is sliced so that the ridges (115) and grooves (122) on one surface of the slices are oriented transversely to the ridges (116) and grooves (124) on the opposite surface of the slices. The sizes and shapes of the ridges and grooves are particularly selected so that each point in the interior of a slice is no greater than a specified distance from an outer surface of the slice. These parameters enable a lattice-cut potato product to consistently achieve a crispy outer surface and a smooth and creamy interior when cooked by baking or microwaving.

Abstract: A lattice-cut potato product is sliced so that the ridges and grooves on one surface of the slices are oriented transversely to the ridges and grooves on the opposite surface of the slices. The sizes and shapes of the ridges and grooves are particularly selected so that each point in the interior of a slice is no greater than a specified distance from an outer surface of the slice. These parameters enable a lattice-cut potato product to consistently achieve a crispy outer surface and a smooth and creamy interior when cooked by baking or microwaving.

Abstract: A blade assembly includes a number of wave-shaped blades arranged substantially parallel to each other, and spaced laterally from each other. The wave-shaped blades are secured to a support. Each wave-shaped blade includes a number of alternating blade peaks and blade troughs. Each blade peak has a maximum, and each blade trough has a minimum. An intermediate portion of the wave-shaped blade is located between the maximum and the minimum of each adjacent blade peak and blade trough. A number of sectioning blades are secured to the support and arranged substantially transverse to the wave-shaped blades. The sectioning blades are aligned with the intermediate portions of the wave-shaped blades. A method of making a cut food product from a starting food product is also disclosed.