Abstract: The inventors have discovered sets of proteinaceous biomarkers which can be measured in biological fluid samples to diagnosis or aid in the diagnosis of Alzheimer's disease and distinguish AD samples from non-demented samples.

Abstract: The inventors have discovered sets of proteinaceous biomarkers which can be measured in biological fluid samples to diagnosis or aid in the diagnosis of Alzheimer's disease and distinguish AD samples from non-demented samples.

Abstract: Provided are methods of classifying biological samples based on high dimensional data obtained from the samples. The methods are especially useful for prediction of a class to which the sample belongs under circumstances in which the data are statistically under-determined. The advent of microarray technologies which provide the ability to measure en masse many different variables (such as gene expression) at once has resulted in the generation of high dimensional data sets, the analysis of which benefits from the methods of the present invention. High dimensional data is data in which the number of variables, p, exceeds the number of independent observations (e.g. samples), N, made. The invention relies on a dimension reduction step followed by a logistic determination step. The methods of the invention are applicable for binary (i.e. univariate) classification and multi-class (i.e. multivariate) classifications.

Abstract: Provided are methods of classifying biological samples based on high dimensional data obtained from the samples. The methods are especially useful for prediction of a class to which the sample belongs under circumstances in which the data are statistically under-determined. The advent of microarray technologies which provide the ability to measure en masse many different variables (such as gene expression) at once has resulted in the generation of high dimensional data sets, the analysis of which benefits from the methods of the present invention. High dimensional data is data in which the number of variables, p, exceeds the number of independent observations (e.g. samples), N, made. The invention relies on a dimension reduction step followed by a logistic determination step. The methods of the invention are applicable for binary (i.e. univariate) classification and multi-class (i.e. multivariate) classifications.

Abstract: Quantitative methods for analyzing measurement errors from nucleic acid arrays are provided. The methods are based on a two component model that approximates a constant standard deviation for very low expression levels, and constant relative standard deviation (RSD) for higher concentrations. Estimates of some model parameters may be obtained without resort to replicated measurements. Also provided are thresholding methods for establishing boundaries between low expression levels, high expression levels, and intermediate expression levels, and methods for estimating actual expression levels from intensity measurements.