Abstract: A method of manufacture and assembly of multiwell plates employing targeted radiation at an interface in order to achieve bonding is disclosed. The method accommodates glass and polymer attachment as well as polymer to polymer attachment. Resultant plates have unique flatness and optical properties.

Abstract: A method of manufacture and assembly of multiwell plates employing targeted radiation at an interface in order to achieve bonding is disclosed. The method accommodates glass and polymer attachment as well as polymer to polymer attachment. Resultant plates have unique flatness and optical properties.

Abstract: A device and methods for performing biological or chemical analysis is provided. The device includes an array of three-dimensional microcolumns projecting away from a support plate. Each microcolumn has a relatively planar, first surface remote from the support plate. An array of multiple, different biological materials may be attached to the first surface. The device, when used in combination with existent micro-titer well plates, can improve efficiency of binding assays using microarrays for high-throughput capacity.

Abstract: A device and methods for performing biological or chemical analysis is provided. The device includes an array of three-dimensional microcolumns projecting away from a support plate. Each microcolumn has a relatively planar, first surface remote from the support plate. An array of multiple, different biological materials may be attached to the first surface. The device, when used in combination with existent micro-titer well plates, can improve efficiency of binding assays using microarrays for high-throughput capacity.

Abstract: A high-throughput cell or tissue culture apparatus, which is configurable to an industry-standard well plate format, is provided. The apparatus comprises a number of vessels, which may be suspended in wells of a plate. Each vessel has at least one sidewall defining a first opening and a second opening, each of predetermined cross-sectional area. The second opening has an inner cross-sectional area greater than either the inner cross-sectional area of the first opening or a cross-sectional area in a horizontal plane between the first and second openings. A relatively large substrate area is provided in each vessel for supporting tissue cultures in a fluid medium.

Abstract: A high-throughput cell or tissue culture apparatus, which is configurable to an industry-standard well plate format, is provided. The apparatus comprises a number of vessels, which may be suspended in wells of a plate. Each vessel has at least one sidewall defining a first opening and a second opening, each of predetermined cross-sectional area. The second opening has an inner cross-sectional area greater than either the inner cross-sectional area of the first opening or a cross-sectional area in a horizontal plane between the first and second openings. A relatively large substrate area is provided in each vessel for supporting tissue cultures in a fluid medium.

Abstract: A device and methods for performing biological or chemical analysis is provided. The device includes an array of three-dimensional microcolumns projecting away from a support plate. Each microcolumn has a relatively planar, first surface remote from the support plate. An array of multiple, different biological materials may be attached to the first surface. The device, when used in combination with existent micro-titer well plates, can improve efficiency of binding assays using microarrays for high-throughput capacity.

Abstract: The present invention includes a method and sensor that is easy to assemble and can operate to effectively detect an air borne or exogenously introduced analyte. In one embodiment, the assembled sensor includes a top cap capable of receiving a first electrolyte and a bottom cap capable of receiving a second electrolyte. The assembled sensor also includes a flexible boot that holds together the top cap, the bottom cap and a membrane. The membrane is located between the first electrolyte and the second electrolyte and enables an electrical device to detect an analyte (e.g., hazardous chemical) which originally entered the sensor through a passage in the top cap and interacted with the membrane.

Abstract: A system, method and device for the detection of reactions between analytes, (e.g., DNA, biomolecules, or cells) and a second compound are disclosed. The present invention includes a coating of a fluorescent material having a fluorescence that changes with temperature. The fluorescent material is associated with a substrate, and can be used for any type of surface reaction that requires determination of temperature conditions at an interface between the surface and the reaction analyte subject to assay. The substrate may be, for example, a microarray chip or microplate, preferably suitable for use in high-throughput screening of biomolecules or cells. Substrates containing the fluorescent material also can be used to compensate for temperature variations in refractive index in optical sensors.

Abstract: A method of manufacture and assembly of multiwell plates employing targeted radiation at an interface in order to achieve bonding is disclosed. The method accommodates glass and polymer attachment as well as polymer to polymer attachment. Resultant plates have unique flatness and optical properties.

Abstract: The present invention includes a method and sensor that is easy to assemble and can operate to effectively detect an air borne or exogenously introduced analyte. In one embodiment, the assembled sensor includes a top cap capable of receiving a first electrolyte and a bottom cap capable of receiving a second electrolyte. The assembled sensor also includes a flexible boot that holds together the top cap, the bottom cap and a biosensor. The biosensor is operational when it is located between the first electrolyte and the second electrolyte and enables an electrical device to detect an analyte (e.g., hazardous chemical) that enters the sensor through a passage in the top cap. In particular, the electrical device can apply a voltage to the first electrolyte, the biosensor and the second electrolyte, and then detect the presence of an analyte interacting with the biosensor by detecting a change in the electrical characteristic of the biosensor caused by the presence of the analyte.

Abstract: The presence of antigens is detected with a device having an antibody immunochemically reactive with the antigen bound to a first microporous membrane coated with an inert proteinaceous material and an antibody immunochemically non-reactive with the antigen bound to a second microporous membrane coated with an inert proteinaceous material. The device is particularly useful in an immunoassay for an antigen of Entamoeba histolytica in unfractionated feces or colon aspirate.