Patents by Inventor David M. Rothwarf
David M. Rothwarf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120228386Abstract: This invention relates generally to the field of moiety or molecule analysis, isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a substrate; and b) a photorecognizable coding pattern on said substrate. Preferably, the microdevice does not comprise an anodized metal surface layer. Methods and kits for isolating, detecting and manipulating moieties, and synthesizing libraries using the microdevices are also provided. The invention further provides two-dimensional optical encoders and uses thereof. In certain embodiments, the invention provides a microdevice, which microdevice comprises: a) a magnetizable substance; and b) a photorecognizable coding pattern, wherein said microdevice has a preferential axis of magnetization. Systems and methods for isolating, detecting and manipulating moieties and synthesizing libraries using the microdevices are also provided.Type: ApplicationFiled: May 21, 2012Publication date: September 13, 2012Applicant: Aviva Biosciences CorporationInventors: Lei WU, Xiaobo Wang, Guoliang Tao, Junquan Xu, Jing Cheng, Mingxian Huang, Baoquan Sun, Wei Shao, Litian Liu, Depu Chen, David M. Rothwarf, Weiping Yang
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Publication number: 20100260984Abstract: This invention relates generally to the field of moiety or molecule analysis, isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a substrate; and b) a photorecognizable coding pattern on said substrate. Preferably, the microdevice does not comprise an anodized metal surface layer. Methods and kits for isolating, detecting and manipulating moieties, and synthesizing libraries using the microdevices are also provided. The invention further provides two-dimensional optical encoders and uses thereof. In certain embodiments, the invention provides a microdevice, which microdevice comprises: a) a magnetizable substance; and b) a photorecognizable coding pattern, wherein said microdevice has a preferential axis of magnetization. Systems and methods for isolating, detecting and manipulating moieties and synthesizing libraries using the microdevices are also provided.Type: ApplicationFiled: April 14, 2010Publication date: October 14, 2010Applicants: AVIVA BIOSCIENCES CORPORATION, TSINGHUA UNIVERSITY, CAPITALBIO CORPORATIONInventors: Lei WU, Xiaobo Wang, Guoliang Tao, Junquan Xu, Jing Cheng, Mingxian Huang, Baoquan Sun, Wei Shao, Litian Liu, Depu Chen, David M. Rothwarf, Weiping Yang
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Microdevice containing photorecognizable coding patterns and methods of using and producing the same
Patent number: 7811768Abstract: This invention relates generally to the field of moiety or molecule analysis, isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a substrate; and b) a photorecognizable coding pattern on the substrate. Preferably, the microdevice does not comprise an anodized metal surface layer. Methods and kits for isolating, detecting and manipulating moieties, and synthesizing libraries using the microdevices are also provided. The invention further provides two-dimensional optical encoders and uses thereof.Type: GrantFiled: August 7, 2001Date of Patent: October 12, 2010Assignees: Aviva Biosciences Corporation, Tsinghua University, CAPTIALBIO CorporationInventors: Lei Wu, Xiaobo Wang, Guoliang Tao, Junquan Xu, Jing Cheng, Mingxiang Huang, Baoquan Sun, Wei Shao, Litian Liu, Depu Chen, David M. Rothwarf, Weiping Yang -
Microdevice containing photorecognizable coding patterns and methods of using and producing the same
Patent number: 7776543Abstract: This invention relates generally to the field of moiety or molecule analysis, isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a substrate; and b) a photorecognizable coding pattern on the substrate. Preferably, the microdevice does not comprise an anodized metal surface layer. Methods and kits for isolating, detecting and manipulating moieties, and synthesizing libraries using the microdevices are also provided. The invention further provides two-dimensional optical encoders and uses thereof.Type: GrantFiled: August 7, 2001Date of Patent: August 17, 2010Assignees: Aviva Biosciences Corporation, Tsinghua University, CAPTIALBIO CorporationInventors: Lei Wu, Xiaobo Wang, Guoliang Tao, Junquan Xu, Jing Cheng, Mingxiang Huang, Baoquan Sun, Wei Shao, Litian Liu, Depu Chen, David M. Rothwarf, Weiping Yang -
Patent number: 7718419Abstract: This invention relates generally to the field of moiety or molecule isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a magnetizable substance; and b) a photorecognizable coding pattern, wherein said microdevice has a preferential axis of magnetization. Systems and methods for isolating, detecting and manipulating moieties and synthesizing libraries using the microdevices are also provided.Type: GrantFiled: August 20, 2007Date of Patent: May 18, 2010Assignee: Aviva Biosciences CorporationInventors: Lei Wu, Xiaobo Wang, Guoliang Tao, Junquan Xu, Jing Cheng, Mingxian Huang, Baoquan Sun, Wei Shao, Litian Liu, Depu Chen, David M. Rothwarf, Weiping Yang
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Publication number: 20100055714Abstract: The present invention provides an isolated nucleic acid molecules encoding I?B kinase (IKK) catalytic subunit polypeptides, which are associated with an IKK serine protein kinase that phosphorylates a protein (I?B) that inhibits the activity of the NF-?B transcription factor, vectors comprising such nucleic acid molecules and host cells containing such vectors. In addition, the invention provides nucleotide sequences that can bind to a nucleic acid molecule of the invention, such nucleotide sequences being useful as probes or as antisense molecules. The invention also provides isolated IKK catalytic subunits, which can phosphorylate an I?B protein, and peptide portions of such IKK subunit. In addition, the invention provides anti-IKK antibodies, which specifically bind to an IKK complex or an IKK catalytic subunit, and IKK-binding fragments of such antibodies.Type: ApplicationFiled: October 31, 2007Publication date: March 4, 2010Inventors: Michael Karin, Joseph A. DiDonato, David M. Rothwarf, Makio Hayakawa, Ebrahim Zandi
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Publication number: 20080200349Abstract: This invention relates generally to the field of moiety or molecule isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a magnetizable substance; and b) a photorecognizable coding pattern, wherein said microdevice has a preferential axis of magnetization. Systems and methods for isolating, detecting and manipulating moieties and synthesizing libraries using the microdevices are also provided.Type: ApplicationFiled: August 20, 2007Publication date: August 21, 2008Applicants: AVIVA BIOSCIENCES CORPORATION, TSINGHUA UNIVERSITY, CAPITAL BIOCHIP CORPORATIONInventors: Lei Wu, Xiaobo Wang, Guoliang Tao, Junquan Xu, Jing Cheng, Mingxiang Huang, Baoquan Sun, Wei Shao, Litian Liu, Depu Chen, David M. Rothwarf, Weiping Yang
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Patent number: 7314615Abstract: The present invention provides an isolated nucleic acid molecules encoding I?B kinase (IKK) catalytic subunit polypeptides, which are associated with an IKK serine protein kinase that phosphorylates a protein (I?B) that inhibits the activity of the NF-?B transcription factor, vectors comprising such nucleic acid molecules and host cells containing such vectors. In addition, the invention provides nucleotide sequences that can bind to a nucleic acid molecule of the invention, such nucleotide sequences being useful as probes or as antisense molecules. The invention also provides isolated IKK catalytic subunits, which can phosphorylate an I?B protein, and peptide portions of such IKK subunit. In addition, the invention provides anti-IKK antibodies, which specifically bind to an IKK complex or an IKK catalytic subunit, and IKK-binding fragments of such antibodies.Type: GrantFiled: December 17, 2003Date of Patent: January 1, 2008Assignee: The Regents of the University of CaliforniaInventors: Michael Karin, Joseph A. DiDonato, David M. Rothwarf, Makio Hayakawa, Ebrahim Zandi
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Patent number: 7262016Abstract: This invention relates generally to the field of moiety or molecule isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a magnetizable substance; and b) a photorecognizable coding pattern, wherein said microdevice has a preferential axis of magnetization. Systems and methods for isolating, detecting and manipulating moieties and synthesizing libraries using the microdevices are also provided.Type: GrantFiled: September 20, 2005Date of Patent: August 28, 2007Assignee: Aviva Biosciences CorporationInventors: Mingxian Huang, Lei Wu, Xiaobo Wang, Junquan Xu, Guo Liang Tao, David M. Rothwarf
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Patent number: 7189832Abstract: The present invention provides a novel essential regulatory subunit of the I?B kinase (IKK) complex, IKK-?. The isolated IKK-? subunit of the invention has substantially the same amino acid sequence as SEQ ID NO: 2 shown in FIG. 2.Type: GrantFiled: August 20, 1999Date of Patent: March 13, 2007Assignee: The Regents of the University of CaliforniaInventors: Michael Karin, David M. Rothwarf, Ebrahim Zandi
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Patent number: 7015047Abstract: This invention relates generally to the field of moiety or molecule isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a magnetizable substance; and b) a photorecognizable coding pattern, wherein said microdevice has a preferential axis of magnetization. Systems and methods for isolating, detecting and manipulating moieties and synthesizing libraries using the microdevices are also provided.Type: GrantFiled: March 21, 2002Date of Patent: March 21, 2006Assignee: Aviva Biosciences CorporationInventors: Mingxian Huang, Lei Wu, Xiaobo Wang, Junquan Xu, Guo Liang Tao, David M. Rothwarf
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Publication number: 20040228849Abstract: The present invention provides an isolated nucleic acid molecules encoding IKB kinase (IKK) catalytic subunit polypeptides, which are associated with an IKK serine protein kinase that phosphorylates a protein (I&kgr;B) that inhibits the activity of the NF-&kgr;B transcription factor, vectors comprising such nucleic acid molecules and host cells containing such vectors. In addition, the invention provides nucleotide sequences that can bind to a nucleic acid molecule of the invention, such nucleotide sequences being useful as probes or as antisense molecules. The invention also provides isolated IKK catalytic subunits, which can phosphorylate an I&kgr;B protein, and peptide portions of such IKK subunit. In addition, the invention provides anti-IKK antibodies, which specifically bind to an IKK complex or an IKK catalytic subunit, and IKK-binding fragments of such antibodies.Type: ApplicationFiled: December 17, 2003Publication date: November 18, 2004Inventors: Michael Karin, Joseph A. DiDonato, David M. Rothwarf, Makio Hayakawa, Ebrahim Zandi
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Patent number: 6689575Abstract: The present invention provides an isolated nucleic acid molecules encoding I&kgr;B kinase (IKK) catalytic subunit polypeptides, which are associated with an IKK serine protein kinase that phosphorylates a protein (I&kgr;B) that inhibits the activity of the NF-&kgr;B transcription factor, vectors comprising such nucleic acid molecules and host cells containing such vectors. In addition, the invention provides nucleotide sequences that can bind to a nucleic acid molecule of the invention, such nucleotide sequences being useful as probes or as antisense molecules. The invention also provides isolated IKK catalytic subunits, which can phosphorylate an I&kgr;B protein, and peptide portions of such IKK subunit. In addition, the invention provides anti-IKK antibodies, which specifically bind to an IKK complex or an IKK catalytic subunit, and IKK-binding fragments of such antibodies.Type: GrantFiled: February 28, 2001Date of Patent: February 10, 2004Assignee: The Regents of the University of CaliforniaInventors: Michael Karin, Joseph A. DiDonato, David M. Rothwarf, Makio Hayakawa, Ebrahim Zandi
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Publication number: 20020187501Abstract: This invention relates generally to the field of moiety or molecule isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a magnetizable substance; and b) a photorecognizable coding pattern, wherein said microdevice has a preferential axis of magnetization. Systems and methods for isolating, detecting and manipulating moieties and synthesizing libraries using the microdevices are also provided.Type: ApplicationFiled: March 21, 2002Publication date: December 12, 2002Inventors: Mingxian Huang, Lei Wu, Xiaobo Wang, Junquan Xu, Guo Liang Tao, David M. Rothwarf
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Publication number: 20020137059Abstract: This invention relates generally to the field of moiety or molecule analysis, isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a substrate; and b) a photorecognizable coding pattern on said substrate. Preferably, the microdevice does not comprise an anodized metal surface layer. Methods and kits for isolating, detecting and manipulating moieties, and synthesizing libraries using the microdevices are also provided. The invention further provides two-dimensional optical encoders and uses thereof.Type: ApplicationFiled: August 7, 2001Publication date: September 26, 2002Inventors: Lei Wu, Xiaobo Wang, Gouliang Tao, Junquan Xu, Jing Cheng, Mingxiang Huang, Baoquan Sun, Wei Shao, Litian Liu, Depu Chen, David M. Rothwarf, Weiping Yang
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Publication number: 20020045235Abstract: The present invention provides an isolated nucleic acid molecules encoding I&kgr;B kinase (IKK) catalytic subunit polypeptides, which are associated with an IKK serine protein kinase that phosphorylates a protein (I&kgr;B) that inhibits the activity of the NF-&kgr;B transcription factor, vectors comprising such nucleic acid molecules and host cells containing such vectors. In addition, the invention provides nucleotide sequences that can bind to a nucleic acid molecule of the invention, such nucleotide sequences being useful as probes or as antisense molecules. The invention also provides isolated IKK catalytic subunits, which can phosphorylate an I&kgr;B protein, and peptide portions of such IKK subunit. In addition, the invention provides anti-IKK antibodies, which specifically bind to an IKK complex or an IKK catalytic subunit, and IKK-binding fragments of such antibodies.Type: ApplicationFiled: February 28, 2001Publication date: April 18, 2002Inventors: Michael Karin, Joseph A. DiDonato, David M. Rothwarf, Makio Hayakawa, Ebrahim Zandi
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Patent number: 6268194Abstract: The present invention provides a substantially purified nucleic acid molecule encoding a serine protein kinase (I&kgr;B kinase) that phosphorylates a protein (I&kgr;B) that inhibits the activity of the NF-&kgr;B transcription factor, vectors comprising such a nucleic acid molecule and host cells containing such vectors. In addition, the invention provides nucleotide sequences that can bind to a nucleic acid molecule of the invention, such nucleotide sequences being useful as probes or as antisense molecules. The invention also provides a substantially purified I&kgr;B kinase, which is a polypeptide that can phosphorylate an I&kgr;B protein, and peptide portions of the I&kgr;B kinase. In addition, the invention provides anti-I&kgr;B kinase antibodies, which specifically bind to an I&kgr;B kinase, and I&kgr;B kinase-binding fragments of such antibodies.Type: GrantFiled: February 25, 1997Date of Patent: July 31, 2001Assignee: The Regents of the University of CaliforniaInventors: Michael Karin, Joseph A. DiDonato, David M. Rothwarf, Makio Hayakawa, Ebrahim Zandi
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Patent number: 6242253Abstract: The present invention provides an isolated nucleic acid molecules encoding IKB kinase (IKK) catalytic subunit polypeptides, which are associated with an IKK serine protein kinase that phosphorylates a protein (IKB) that inhibits the activity of the NF-KB transcription factor, vectors comprising such nucleic acid molecules and host cells containing such vectors. In addition, the invention provides nucleotide sequences that can bind to a nucleic acid molecule of the invention, such nucleotide sequences being useful as probes or as antisense molecules. The invention also provides isolated IKK catalytic subunits, which can phosphorylate an IKB protein, and peptide portions of such IKK subunit. In addition, the invention provides anti-IKK antibodies, which specifically bind to an IKK complex or an IKK catalytic subunit, and IKK-binding fragments of such antibodies.Type: GrantFiled: October 8, 1998Date of Patent: June 5, 2001Assignee: Regents of the University of CaliforniaInventors: Michael Karin, Joseph A. DiDonato, David M. Rothwarf, Makio Hayakawa, Ebrahim Zandi