Patents by Inventor David M. Shames

David M. Shames has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Imaging method for the grading of tumors
    Patent number: 6009342
    Abstract: The endothelial integrity of microvessels is disturbed in malignant tumors. We invented a method wherein we used MRI to define tumor microvascular permeabilities and correlated these permeabilities with histologic grade in tumors. Using macromolecular MRI contrast medium, we discovered tumor microvascular permeability values were significantly lower in benign tumors than in carcinomas. In addition, we found that the microvascular permeability values demonstrated a strong correlation with the histologic grade of carcinomas as determined by the Scarff-Bloom-Richardson grading system.
    Type: Grant
    Filed: February 27, 1998
    Date of Patent: December 28, 1999
    Assignee: The Regents of the University of California
    Inventors: Robert C. Brasch, Heike E. Daldrup, David M. Shames