Patents by Inventor David M. Shanahan
David M. Shanahan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20200246787Abstract: Biosafety units, methods of making and sealing the same are disclosed herein. The present invention includes a unitary structure able to be validated for pharmaceutical manufacturing comprising: at least one controlled air, sealable, sterilizable cleanroom; a mechanical system room adjacent to and separate from the cleanroom comprising: one or more air handling units that provide conditioned air to the cleanroom; and one or more power busses that provide power to electrical outlets in the cleanroom from two sources, wherein the at least two power supplies are connectable to one or more external electrical power sources; an integrated fire suppression system integral to the cleanroom; and one or more corridor connectors, wherein a corridor can be attached at the corridor connector.Type: ApplicationFiled: April 21, 2020Publication date: August 6, 2020Applicant: G-CON Manufacturing, Inc.Inventors: R. Barry Holtz, Troy Arledge, Phillip B. Maples, David M. Shanahan
-
Patent number: 10654036Abstract: Biosafety units, methods of making and sealing the same are disclosed herein. The present invention includes a unitary structure able to be validated for pharmaceutical manufacturing comprising: at least one controlled air, sealable, sterilizable cleanroom; a mechanical system room adjacent to and separate from the cleanroom comprising: one or more air handling units that provide conditioned air to the cleanroom; and one or more power busses that provide power to electrical outlets in the cleanroom from two sources, wherein the at least two power supplies are connectable to one or more external electrical power sources; an integrated fire suppression system integral to the cleanroom; and one or more corridor connectors, wherein a corridor can be attached at the corridor connector.Type: GrantFiled: October 6, 2017Date of Patent: May 19, 2020Assignee: G-CON Manufacturing, Inc.Inventors: R. Barry Holtz, Troy Arledge, Phillip B. Maples, David M. Shanahan
-
Patent number: 9914977Abstract: In certain preferred embodiments, the invention provides methods for treating cancer, which comprise (a) obtaining a specimen of cancer tissue from a patient; (b) obtaining a specimen of normal tissue in the proximity of the cancer tissue from such patient; (c) extracting total protein and RNA from the cancer tissue and normal tissue; (d) obtaining a protein expression profile of the cancer tissue and normal tissue using 2D DIGE and mass spectrometry; (e) identifying proteins that are expressed in such cancer tissue at significantly different levels than in the normal tissue; (f) obtaining a gene expression profile of the cancer tissue and normal tissue using microarray technology and comparing the results thereof to the protein expression profile; (g) prioritizing over-expressed proteins by assessing the connectivity thereof to other cancer-related or stimulatory proteins; (h) designing an appropriate RNA interference expression cassette to, directly or indirectly, modulate the expression of genes encoding sType: GrantFiled: June 3, 2016Date of Patent: March 13, 2018Assignee: GRADALIS, INC.Inventors: David M. Shanahan, John J. Nemunaitis, Neil Senzer, Phillip B. Maples, Donald Rao
-
Publication number: 20180043347Abstract: Biosafety units, methods of making and sealing the same are disclosed herein. The present invention includes a unitary structure able to be validated for pharmaceutical manufacturing comprising: at least one controlled air, sealable, sterilizable cleanroom; a mechanical system room adjacent to and separate from the cleanroom comprising: one or more air handling units that provide conditioned air to the cleanroom; and one or more power busses that provide power to electrical outlets in the cleanroom from two sources, wherein the at least two power supplies are connectable to one or more external electrical power sources; an integrated fire suppression system integral to the cleanroom; and one or more corridor connectors, wherein a corridor can be attached at the corridor connector.Type: ApplicationFiled: October 6, 2017Publication date: February 15, 2018Applicant: G-CON Manufacturing, Inc.Inventors: R. Barry Holtz, Troy Arledge, Phillip B. Maples, David M. Shanahan
-
Patent number: 9795957Abstract: Biosafety units, methods of making and sealing the same are disclosed herein. The present invention includes a unitary structure able to be validated for pharmaceutical manufacturing comprising: at least one controlled air, sealable, sterilizable cleanroom; a mechanical system room adjacent to and separate from the cleanroom comprising: one or more air handling units that provide conditioned air to the cleanroom; and one or more power busses that provide power to electrical outlets in the cleanroom from two sources, wherein the at least two power supplies are connectable to one or more external electrical power sources; an integrated fire suppression system integral to the cleanroom; and one or more corridor connectors, wherein a corridor can be attached at the corridor connector.Type: GrantFiled: November 6, 2012Date of Patent: October 24, 2017Assignee: G-CON MANUFACTURING, INC.Inventors: R. Barry Holtz, Troy Arledge, Phillip B. Maples, David M. Shanahan
-
Patent number: 9765980Abstract: Biosafety units, methods of making, and sealing the same are disclosed herein. The units comprise at least one controlled air, sealable, sterilizable cleanroom; and a mechanical system room adjacent to the cleanroom comprising: at least two air handling units in a support room adjacent the cleanroom that provide redundant air to the cleanroom with at least Class 100,000 air purity, the air handling units connected to a one or more supply ducts to the cleanroom, and an exhaust duct in communication with the cleanroom and the air handling unit exhaust, wherein a pressure gradient is formed between the cleanroom and the exterior of the structure; and at least two power supplies that provide redundant power to electrical outlets in the cleanroom, wherein the at least two power supplies are connectable to one or more external power sources and the structure is pre-validatable or validated for pharmaceutical manufacturing.Type: GrantFiled: September 18, 2015Date of Patent: September 19, 2017Assignee: G-CON MANUFACTURING, INC.Inventors: R. Barry Holtz, Troy Arledge, Philip B. Maples, David M. Shanahan
-
Publication number: 20170175124Abstract: In certain embodiments, the invention provides methods for treating cancer, comprising: obtaining a specimen of cancer tissue and normal tissue from a patient; extracting total protein; obtaining a protein expression profile; identifying over-expressed proteins; comparing the protein expression profile to a gene expression profile; identifying at least one prioritized protein target; designing a first RNA interference expression cassette; designing a first RNA interference expression cassette to modulate the expression of at least one gene encoding; incorporating the first cassette into a delivery vehicle; and providing a patient with an effective amount of the first delivery vehicle.Type: ApplicationFiled: December 21, 2016Publication date: June 22, 2017Inventors: David M. Shanahan, John J. Nemunaitis, Neil Senzer, Phillip B. Maples, Donald Rao
-
Publication number: 20170073768Abstract: In certain preferred embodiments, the invention provides methods for treating cancer, which comprise (a) obtaining a specimen of cancer tissue from a patient; (b) obtaining a specimen of normal tissue in the proximity of the cancer tissue from such patient; (c) extracting total protein and RNA from the cancer tissue and normal tissue; (d) obtaining a protein expression profile of the cancer tissue and normal tissue using 2D DIGE and mass spectrometry; (e) identifying proteins that are expressed in such cancer tissue at significantly different levels than in the normal tissue; (f) obtaining a gene expression profile of the cancer tissue and normal tissue using microarray technology and comparing the results thereof to the protein expression profile; (g) prioritizing over-expressed proteins by assessing the connectivity thereof to other cancer-related or stimulatory proteins; (h) designing an appropriate RNA interference expression cassette to, directly or indirectly, modulate the expression of genes encoding sType: ApplicationFiled: June 3, 2016Publication date: March 16, 2017Inventors: David M. Shanahan, John J. Nemunaitis, Neil Senzer, Phillip B. Maples, Donald Rao
-
Patent number: 9528991Abstract: In certain embodiments, the invention provides methods for treating cancer, comprising: obtaining a specimen of cancer tissue and normal tissue from a patient; extracting total protein; obtaining a protein expression profile; identifying over-expressed proteins; comparing the protein expression profile to a gene expression profile; identifying at least one prioritized protein target; designing a first RNA interference expression cassette; designing a first RNA interference expression cassette to modulate the expression of at least one gene encoding; incorporating the first cassette into a delivery vehicle; and providing a patient with an effective amount of the first delivery vehicle.Type: GrantFiled: November 7, 2014Date of Patent: December 27, 2016Assignee: GRADALIS, INC.Inventors: David M. Shanahan, John J. Nemunaitis, I, Neil Senzer, Phillip B. Maples, Donald Rao
-
Patent number: 9518748Abstract: Biosafety units, methods of making, and sealing the same are disclosed herein. The units comprise at least one controlled air, sealable, sterilizable cleanroom; and a mechanical system room adjacent to the cleanroom comprising: at least two air handling units in a support room adjacent the cleanroom that provide redundant air to the cleanroom with at least Class 100,000 air purity, the air handling units connected to a one or more supply ducts to the cleanroom, and an exhaust duct in communication with the cleanroom and the air handling unit exhaust, wherein a pressure gradient is formed between the cleanroom and the exterior of the structure; and at least two power supplies that provide redundant power to electrical outlets in the cleanroom, wherein the at least two power supplies are connectable to one or more external power sources and the structure is pre-validatable or validated for pharmaceutical manufacturing.Type: GrantFiled: August 16, 2010Date of Patent: December 13, 2016Assignee: G-CON MANUFACTURING INC.Inventors: R. Barry Holtz, Troy Arledge, Phillip B. Maples, David M. Shanahan
-
Publication number: 20160010884Abstract: Biosafety units, methods of making, and sealing the same are disclosed herein. The units comprise at least one controlled air, sealable, sterilizable cleanroom; and a mechanical system room adjacent to the cleanroom comprising: at least two air handling units in a support room adjacent the cleanroom that provide redundant air to the cleanroom with at least Class 100,000 air purity, the air handling units connected to a one or more supply ducts to the cleanroom, and an exhaust duct in communication with the cleanroom and the air handling unit exhaust, wherein a pressure gradient is formed between the cleanroom and the exterior of the structure; and at least two power supplies that provide redundant power to electrical outlets in the cleanroom, wherein the at least two power supplies are connectable to one or more external power sources and the structure is pre-validatable or validated for pharmaceutical manufacturing.Type: ApplicationFiled: September 18, 2015Publication date: January 14, 2016Applicant: G-CON MANUFACTURING, INC.Inventors: R. Barry Holtz, Troy Arledge, Philip B. Maples, David M. Shanahan
-
Publication number: 20150086619Abstract: In certain embodiments, the invention provides methods for treating cancer, comprising: obtaining a specimen of cancer tissue and normal tissue from a patient; extracting total protein; obtaining a protein expression profile; identifying over-expressed proteins; comparing the protein expression profile to a gene expression profile; identifying at least one prioritized protein target; designing a first RNA interference expression cassette; designing a first RNA interference expression cassette to modulate the expression of at least one gene encoding; incorporating the first cassette into a delivery vehicle; and providing a patient with an effective amount of the first delivery vehicle.Type: ApplicationFiled: November 7, 2014Publication date: March 26, 2015Inventors: David M. Shanahan, John J. Nemunaitis, I, Neil Senzer, Phillip B. Maples, Donald Rao
-
Publication number: 20120192486Abstract: A light weight and modular light emitting diode (LED) light bar comprising an extruded aluminum LED fixture frame with integral cooling fins is disclosed herein. The light bar of the present invention is used for high density multi-layer hydroponic grow facilities to greatly improve the uniformity and intensity of light distribution over the plants and at a much reduced energy cost and less heat-to-space compared to conventional lighting used in grow rooms.Type: ApplicationFiled: November 11, 2011Publication date: August 2, 2012Applicants: ILLUMITEX, INC., G-CON, LLCInventors: David M. Shanahan, R. Barry Holtz, Paul Winberg
-
Publication number: 20120035249Abstract: A technique for treating obesity, diabetes, and other endocrinological disorders by removal of the omentum by endoscopic and oral approaches is described herein. The removal of the omentum interferes with the glucose absorption or ghrelin production thereby improving and correcting the obesity and diabetes.Type: ApplicationFiled: June 10, 2011Publication date: February 9, 2012Inventors: Joseph A. Kuhn, David M. Shanahan
-
Publication number: 20110053486Abstract: Biosafety units, methods of making, and sealing the same are disclosed herein. The units comprise at least one controlled air, sealable, sterilizable cleanroom; and a mechanical system room adjacent to the cleanroom comprising: at least two air handling units in a support room adjacent the cleanroom that provide redundant air to the cleanroom with at least Class 100,000 air purity, the air handling units connected to a one or more supply ducts to the cleanroom, and an exhaust duct in communication with the cleanroom and the air handling unit exhaust, wherein a pressure gradient is formed between the cleanroom and the exterior of the structure; and at least two power supplies that provide redundant power to electrical outlets in the cleanroom, wherein the at least two power supplies are connectable to one or more external power sources and the structure is pre-validatable or validated for pharmaceutical manufacturing.Type: ApplicationFiled: August 16, 2010Publication date: March 3, 2011Applicant: G-CON, LLCInventors: R. Barry Holtz, Troy Arledge, Phillip B. Maples, David M. Shanahan
-
Patent number: D383335Type: GrantFiled: February 23, 1996Date of Patent: September 9, 1997Assignee: Keller Ladders, Inc.Inventors: David M. Shanahan, J. Dennis Gordon
-
Patent number: D392820Type: GrantFiled: July 26, 1996Date of Patent: March 31, 1998Assignee: Keller Ladders, Inc.Inventors: David M Shanahan, J. Dennis Gordon
-
Patent number: D404502Type: GrantFiled: January 24, 1997Date of Patent: January 19, 1999Assignee: Keller Ladders, Inc.Inventor: David M. Shanahan