Abstract: Provided herein are phosphodiesterase 4 (PDE4) degraders, e.g., a compound of Formula (I) or (IA), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a PDE4-mediated disease, disorder, or condition.

Abstract: This invention pertains to an ultrafiltration process which maintains a constant developer strength in a printing plate developing operation. Such a process enables development of more plates than conventional processes while using less developer and generating less liquid waste. The ultrafiltration process is suitable for both batch and continuous plate development operations. By this process, used developer is filtered and the fluid portion returned to the working developer solution. The filtered out remainder mass is treated with an absorber to convert it into a solid.

Abstract: This invention discloses a novel process to maintain constant developer strength in a printing plate manufacturing operation. Such a process enables development of more plates than conventional processes allow, while at the same time using less quantity of developer and generating fewer liquid waste. The process is suitable for both batch type and continuous plate development operations. The invention also describes an apparatus suitable for the above-described process.

Abstract: A handcuff assembly for use by law enforcement officers to lock a prisoner's wrists together. A pair of handcuffs are connected together by a linkage that prevents flexion, rotation, and adduction of the prisoner's hand and wrist, muscles, etc., while allowing the assembly to fold flat for storage while also being capable of folding over an equipment belt.