Patents by Inventor David M. Truong

David M. Truong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROTEIN-BASED MATERIAL FOR BIOCATALYSIS
    Publication number: 20240116992
    Abstract: Provided herein are compositions and methods for stabilizing enzymes. Also provided are systems, compositions and methods for using the stabilized enzymes to produce a desired compound.
    Type: Application
    Filed: February 2, 2022
    Publication date: April 11, 2024
    Applicant: Bondwell Technologies LP
    Inventors: David W. Howell, Sarah E. Bondos, Rebecca M. Booth, Christi Parham, Dat P. Truong, Rebecca E. Skouby
  • Budding yeast with human chromatin
    Patent number: 11858968
    Abstract: Yeast having modified chromosomes are provided. The chromosomes are modified such that at least one of yeast histones H3, H4, H2A or H2B are fully or partially replaced by their human histone counterparts H3, H4, H2A or H2B, respectively. Histone amino acid substitutions are included. Cell fusions with the yeast having the modified chromosomes and non-yeast cells are provided. Methods for screening test agents using the yeast are also provided. Yeast with a mutated yeast DAD1 gene, the mutated DAD1 gene encoding an E50D mutation in yeast DAD1 protein, are provided, and provide a useful genetic background for making the yeast with partially or fully replaced histone(s).
    Type: Grant
    Filed: July 6, 2021
    Date of Patent: January 2, 2024
    Assignee: New York University
    Inventors: David M. Truong, Jef D. Boeke
  • BUDDING YEAST WITH HUMAN CHROMATIN
    Publication number: 20210403513
    Abstract: Yeast having modified chromosomes are provided. The chromosomes are modified such that at least one of yeast histones H3, H4, H2A or H2B are fully or partially replaced by their human histone counterparts H3, H4, H2A or H2B, respectively. Histone amino acid substitutions are included. Cell fusions with the yeast having the modified chromosomes and non-yeast cells are provided. Methods for screening test agents using the yeast are also provided. Yeast with a mutated yeast DAD1 gene, the mutated DAD1 gene encoding an E50D mutation in yeast DAD1 protein, are provided, and provide a useful genetic background for making the yeast with partially or fully replaced histone(s).
    Type: Application
    Filed: July 6, 2021
    Publication date: December 30, 2021
    Inventors: David M. Truong, Jef D. Boeke
  • Budding yeast with human chromatin
    Patent number: 11053289
    Abstract: Yeast having modified chromosomes are provided. The chromosomes are modified such that at least one of yeast histones H3, H4, H2A or H2B are fully or partially replaced by their human histone counterparts H3, H4, H2A or H2B, respectively. Histone amino acid substitutions are included. Cell fusions with the yeast having the modified chromosomes and non-yeast cells are provided. Methods for screening test agents using the yeast are also provided. Yeast with a mutated yeast DAD1 gene, the mutated DAD1 gene encoding an E50D mutation in yeast DAD1 protein, are provided, and provide a useful genetic background for making the yeast with partially or fully replaced histone(s).
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: July 6, 2021
    Assignee: New York University
    Inventors: David M. Truong, Jef D. Boeke
  • BUDDING YEAST WITH HUMAN CHROMATIN
    Publication number: 20190023752
    Abstract: Yeast having modified chromsomes are provided. The chromosomes are modified such that at least one of yeast histones H3, H4, H2A or H2B are fully or partially replaced by their human histone counterparts H3, H4, H2A or H2B, respectively. Histone amino acid substitutions are included. Cell fusions with the yeast having the modified chromosomes and non-yeast cells are provided. Methods for screening test agents using the yeast are also provided. Yeast with a mutated yeast DAD1 gene, the mutated DAD1 gene encoding an E50D mutation in yeast DAD1 protein, are provided, and provide a useful genetic background for making the yeast with partially or fully replaced histone(s).
    Type: Application
    Filed: July 23, 2018
    Publication date: January 24, 2019
    Inventors: David M. Truong, Jef D. Boeke