Abstract: The present invention concerns a family of nucleic acids, polypeptides and cloning vectors which direct expression of fusion proteins that can mimic aggregated IgG (AIG) and immune complex function with respect to their interactions with Fc?R and which allow for the inclusion and targeting of a second protein domain to cells expressing Fc?R. This was accomplished by expressing multiple linear copies of the hinge and CH2 domains (HCH2) of human IgG1 fused to the framework region of human IgG1. Convenient restriction sites allow for the facile introduction of additional amino-terminal domains. Methods for treating patients using fusion proteins are also disclosed. The HCH2 polymers described here represent a new strategy in the design of recombinant proteins for the therapeutic targeting of Fc?R in autoimmune disorders.

Abstract: Disclosed methods for detecting remnant cancer cells in a tissue sample.

Abstract: Disclosed methods for detecting remnant cancer cells in a tissue sample.

Abstract: The present invention concerns a family of nucleic acids, polypeptides and cloning vectors which direct expression of fusion proteins that can mimic aggregated IgG (AIG) and immune complex function with respect to their interactions with Fc?R and which allow for the inclusion and targeting of a second protein domain to cells expressing Fc?R. This was accomplished by expressing multiple linear copies of the hinge and CH2 domains (HCH2) of human IgG1 fused to the framework region of human IgG1. Convenient restriction sites allow for the facile introduction of additional amino-terminal domains. Methods for treating patients using fusion proteins are also disclosed. The HCH2 polymers described here represent a new strategy in the design of recombinant proteins for the therapeutic targeting of Fc?R in autoimmune disorders.

Abstract: A structure modification system may include a structure attachment portion secured to a structure, an articulating arm connected to the structure attachment portion, and a mechanical tool connected to the articulating arm. The mechanical tool may be a saw and the structure may be a vertically oriented pole or column. The structure attachment portion may be secured to the structure with one or more straps, which may wrap around the structure. The articulating arm may include first and second arm segments which may pivot with respect to one another. The operation of the system may allow for a horizontal cut of the structure by the saw from any side of the structure.

Abstract: The present invention concerns a family of nucleic acids, polypeptides and cloning vectors which direct expression of fusion proteins that can mimic aggregated IgG (AIG) and immune complex function with respect to their interactions with Fc?R and which allow for the inclusion and targeting of a second protein domain to cells expressing Fc?R. This was accomplished by expressing multiple linear copies of the hinge and CH2 domains (HCH2) of human IgG1 fused to the framework region of human IgG1. Convenient restriction sites allow for the facile introduction of additional amino-terminal domains. Methods for treating patients using fusion proteins are also disclosed. The HCH2 polymers described here represent a new strategy in the design of recombinant proteins for the therapeutic targeting of Fc?R in autoimmune disorders.

Abstract: The present invention concerns a family of nucleic acids, polypeptides and cloning vectors which direct expression of fusion proteins that can mimic aggregated IgG (AIG) and immune complex function with respect to their interactions with Fc?R and which allow for the inclusion and targeting of a second protein domain to cells expressing Fc?R. This was accomplished by expressing multiple linear copies of the hinge and CH2 domains (HCH2) of human IgG1 fused to the framework region of human IgG1. Convenient restriction sites allow for the facile introduction of additional amino-terminal domains. Methods for treating patients using fusion proteins are also disclosed. The HCH2 polymers described here represent a new strategy in the design of recombinant proteins for the therapeutic targeting of Fc?R in autoimmune disorders.

Abstract: The present invention concerns a family of nucleic acids, polypeptides and cloning vectors which direct expression of fusion proteins that can mimic aggregated IgG (AIG) and immune complex function with respect to their interactions with Fc?R and which allow for the inclusion and targeting of a second protein domain to cells expressing Fc?R. This was accomplished by expressing multiple linear copies of the hinge and CH2 domains (HCH2) of human IgG1 fused to the framework region of human IgG1. Convenient restriction sites allow for the facile introduction of additional amino-terminal domains. Methods for treating patients using fusion proteins are also disclosed. The HCH2 polymers described here represent a new strategy in the design of recombinant proteins for the therapeutic targeting of Fc?R in autoimmune disorders.

Abstract: An axle assembly includes an electric drive motor oriented along an axis and disposed within a central axle housing. The electric drive motor includes a motor housing having an engagement face perpendicular to the axis. A spindle assembly includes an external connection to the central axle housing and an internal engagement face that is perpendicular to the axis. A sealing member is in sealing contact with the engagement face of the motor housing and the internal engagement face of the spindle assembly.

Abstract: A cover plate for a drive assembly that includes a bearing housing having a bearing cavity, a thrust bearing axially disposed within the bearing cavity that includes a cup, cone and plurality of rollers disposed between cup and cone raceways, a thrust plate with an axle engaging surface disposed perpendicular to a central axis and coupled for rotation to the cone. The cover plate may be connected to a final drive housing of a final drive that includes a plurality of gears operatively connected to an axle shaft, the end of the axle shaft positioned to rotationally engage the thrust plate and cone.

Abstract: A thrust plate for use in a drive assembly between an end of an axle shaft and a bearing, the bearing retained within a housing of a rotatable final drive component, the thrust plate having a first end that defines an axle engaging wear surface and a second end that includes an extension configured for fitted engagement with the bearing, the thrust plate further including a central axis of rotation, where the axle engaging wear surface is disposed transverse to the central axis. A thrust plate and bearing assembly for a final drive cover plate includes the thrust plate in combination with a spherical thrust bearing, these components also being provided in a rebuild kit.

Abstract: The present invention concerns inventive polypeptides. The present invention also concerns compositions and vaccines comprising the inventive polypeptides. In other embodiments of the invention, the inventive polypeptides are provided to a subject, used to vaccinate, or used to induce immunity. Other embodiments include methods for making the inventive polypeptides and nucleic acids used to encode the inventive polypeptides.

Abstract: The present invention concerns a family of nucleic acids, polypeptides and cloning vectors which direct expression of fusion proteins that can mimic aggregated IgG (AIG) and immune complex function with respect to their interactions with Fc?R and which allow for the inclusion and targeting of a second protein domain to cells expressing Fc?R. This was accomplished by expressing multiple linear copies of the hinge and CH2 domains (HCH2) of human IgG1 fused to the framework region of human IgG1. Convenient restriction sites allow for the facile introduction of additional amino-terminal domains. Methods for treating patients using fusion proteins are also disclosed. The HCH2 polymers described here represent a new strategy in the design of recombinant proteins for the therapeutic targeting of Fc?R in autoimmune disorders.

Abstract: A thrust plate for use in a drive assembly between an end of an axle shaft and a bearing, the bearing retained within a housing of a rotatable final drive component, the thrust plate having a first end that defines an axle engaging wear surface and a second end that includes an extension configured for fitted engagement with the bearing, the thrust plate further including a central axis of rotation, where the axle engaging wear surface is disposed transverse to the central axis. A thrust plate and bearing assembly for a final drive cover plate includes the thrust plate in combination with a spherical thrust bearing, these components also being provided in a rebuild kit.

Abstract: A cover plate for a drive assembly that includes a bearing housing having a bearing cavity, a thrust bearing axially disposed within the bearing cavity that includes a cup, cone and plurality of rollers disposed between cup and cone raceways, a thrust plate with an axle engaging surface disposed perpendicular to a central axis and coupled for rotation to the cone. The cover plate may be connected to a final drive housing of a final drive that includes a plurality of gears operatively connected to an axle shaft, the end of the axle shaft positioned to rotationally engage the thrust plate and cone.

Abstract: The present invention concerns a family of nucleic acids, polypeptides and cloning vectors which direct expression of fusion proteins that can mimic aggregated IgG (AIG) and immune complex function with respect to their interactions with Fc?R and which allow for the inclusion and targeting of a second protein domain to cells expressing Fc?R. This was accomplished by expressing multiple linear copies of the hinge and CH2 domains (HCH2) of human IgG1 fused to the framework region of human IgG1. Convenient restriction sites allow for the facile introduction of additional amino-terminal domains. Methods for treating patients using fission proteins are also disclosed. The HCH2 polymers described here represent a new strategy in the design of recombinant proteins for the therapeutic targeting of Fc?R in autoimmune disorders.

Abstract: The present disclosure is directed towards apparatuses, systems and methods for providing improved sensor-based patient monitoring and tracking. In accordance with one aspect, a method is provided for adjusting a vital sign alarm threshold of a vital status sensor as a function of a patient's GPS data, which may comprise: altitude data, velocity data, and position data. In accordance with another aspect, a method is provided for adjusting one or more alarm detection parameters based in part on a patient's calculated heart rate variability (HRV) data. According to yet another aspect, an electronic triage tag is configured to include a colored card insertion region for inserting a colored card for preventing the device from being inadvertently activated, an LCD screen and a series of LEDs for displaying the triage status of a patient (red, yellow, green, black).

Abstract: An axle assembly includes an electric drive motor oriented along an axis and disposed within a central axle housing. The electric drive motor includes a motor housing having an engagement face perpendicular to the axis. A spindle assembly includes an external connection to the central axle housing and an internal engagement face that is perpendicular to the axis. A sealing member is in sealing contact with the engagement face of the motor housing and the internal engagement face of the spindle assembly.

Abstract: The present invention concerns a family of nucleic acids, polypeptides and cloning vectors which direct expression of fusion proteins that can mimic aggregated IgG (AIG) and immune complex function with respect to their interactions with Fc?R and which allow for the inclusion and targeting of a second protein domain to cells expressing Fc?R. This was accomplished by expressing multiple linear copies of the hinge and CH2 domains (HCH2) of human IgG1 fused to the framework region of human IgG1. Convenient restriction sites allow for the facile introduction of additional amino-terminal domains. Methods for treating patients using fission proteins are also disclosed. The HCH2 polymers described here represent a new strategy in the design of recombinant proteins for the therapeutic targeting of Fc?R in autoimmune disorders.

Abstract: The present invention concerns a family of nucleic acids, polypeptides and cloning vectors which direct expression of fusion proteins that can mimic aggregated IgG (AIG) and immune complex function with respect to their interactions with Fc?R and which allow for the inclusion and targeting of a second protein domain to cells expressing Fc?R. This was accomplished by expressing multiple linear copies of the hinge and CH2 domains (HCH2) of human IgG1 fused to the framework region of human IgG1. Convenient restriction sites allow for the facile introduction of additional amino-terminal domains. Methods for treating patients using fusion proteins are also disclosed. The HCH2 polymers described here represent a new strategy in the design of recombinant proteins for the therapeutic targeting of Fc?R in autoimmune disorders.