Abstract: Embodiments are directed towards a use of a supported biphenylphenol polymerization catalyst to make a polymer via a slurry-phase polymerization process, where the supported biphenylphenol polymerization catalyst is made from a biphenylphenol polymerization precatalyst of Formula I.

Abstract: A semiconductor structure is presented including a first level of interconnect wiring separated into a first interconnect wiring segment and a second interconnect wiring segment, the first interconnect wiring segment defining a first line segment and the second interconnect wiring segment defining a second line segment and a second level interconnect wiring positioned orthogonally to the first level of interconnect wiring. A distalmost end of the first line segment and a distalmost end of the second line segment are separated by a spacing less than or equal to a spacing of the second level interconnect wiring defining a zero track skip.

Abstract: This invention is related to the use of a volatile antimicrobial compound against pathogens. The volatile antimicrobial compounds provided include certain oxaborole compounds, for example benzoxaboroles. Delivery systems are provided to take advantage of the volatile nature of these antimicrobial compounds. The method and use disclosed can be combined with other volatile compounds.

Abstract: Nutritive proteins are provided herein. Also provided are various other embodiments including nucleic acids encoding the proteins, recombinant microorganisms that make the proteins, vectors for expressing the proteins, methods of making the proteins using recombinant microorganisms, compositions that comprise the proteins, and methods of using the proteins. Nutritive proteins include engineered proteins, wherein the engineered proteins comprise a sequence of at least 20 amino acids that comprise an altered amino acid sequence compared to the amino acid sequence of a reference secreted protein and a ratio of essential amino acids to total amino acids present in the engineered protein higher than the ratio of essential amino acids to total amino acids present in the reference secreted protein. In some embodiments, the engineered protein comprises at least one essential amino acid residue substitution of a non-essential amino acid residue in the reference secreted protein.

Abstract: A method for producing a secreted recombinant polypeptide sequence is provided. In some embodiments it comprises providing a recombinant microorganism comprising a recombinant nucleic acid comprising a first nucleic acid sequence encoding the recombinant polypeptide sequence operatively linked to a second nucleic acid sequence encoding a signal peptide; and culturing the recombinant microorganism in a culture medium under conditions sufficient for production and secretion of the recombinant protein by the recombinant microorganism. In some embodiments the coding sequence for the signal peptide is not native to the recombinant microorganism. In some embodiments the recombinant microorganism is photo synthetic. Also provided are recombinant photosynthetic microorganisms, isolated polypeptides comprising a signal peptide comprising an amino acid sequence disclosed herein, and isolated nucleic acids comprising a coding sequence for one of the signal peptides, among other things.

Abstract: Methods of producing an unsaturated free fatty acid comprising at least 18 carbon atoms are provided. In some embodiments, the methods comprise culturing an engineered microorganism in a culture medium, wherein the engineered microorganism comprises at least one recombinant enzyme selected from acyl-lipid desaturase delta-9 (EC:1.14.19.1), acyl-lipid desaturase delta-12 (EC:1.14.19.6), acyl-lipid desaturase delta-15 (EC:1.14.19.-), and thioesterase (EC:3.1.2.14). Engineered microorganisms comprising at least one of those recombinant enzymes are also provided. The methods and organisms can be used to produce at least one free fatty acid selected from oleic acid, linoleic acid and ?-linolenic acid.

Abstract: A biological method for the conversion of L-glutamate to 1,4-butanediol that involves a decarboxylation step and avoids production of 4-hydroxybutyrate as an intermediate is described. The method includes: (a) conversion of L-glutamate to L-glutamate 5-phosphate; (b) conversion of L-glutamate 5-phosphate to L-glutamate 5-semialdehyde; (c) conversion of L-glutamate 5-semialdehyde to 5-hydroxy-L-norvaline; (d) conversion of 5-hydroxy-L-norvaline to 5-hydroxy-2-oxopentanoate; (e) conversion of 5-hydroxy-2-oxopentanoate to 4-hydroxybutanal; and (f) the conversion of 4-hydroxybutanal to 1,4-butanediol.

Abstract: The present invention provides methods and compositions useful in localized transfer of genetic material or proteins. Moreover, the present invention provides methods and compositions for improving and/or controlling wound healing by applying a wound care device comprising HoxD3 and/or HoxA3 and/or HoxB3. In addition, the present invention provides methods and compositions for improved wound healing in subjects having impaired healing capabilities, such as diabetic and aged subjects.

Abstract: The present invention provides methods and compositions useful in localized transfer of genetic material or proteins. Moreover, the present invention provides methods and compositions for improving and/or controlling wound healing by applying a wound care device comprising HoxD3 and/or HoxA3 and/or HoxB3. In addition, the present invention provides methods and compositions for improved wound healing in subjects having impaired healing capabilities, such as diabetic subjects.

Abstract: The present invention provides methods and compositions useful in localized transfer of genetic material or proteins. Moreover, the present invention provides methods and compositions for improving and/or controlling wound healing by applying a wound care device comprising HoxD3 and/or HoxA3. In addition, the present invention provides methods and compositions for improved wound healing in subjects having impaired healing capabilities, such as diabetic subjects.

Abstract: The present invention provides methods and compositions useful in localized transfer of genetic material or proteins. Moreover, the present invention provides methods and compositions for improving and/or controlling wound healing by applying a wound care device comprising HoxD3 and/or HoxA3 and/or HoxB3. In addition, the present invention provides methods and compositions for improved wound healing in subjects having impaired healing capabilities, such as diabetic subjects.

Abstract: The present invention provides methods and compositions useful in localized transfer of genetic material or proteins. Moreover, the present invention provides methods and compositions for improving and/or controlling wound healing by applying a wound care device comprising HoxD3 and/or HoxA3. In addition, the present invention provides methods and compositions for improved wound healing in subjects having impaired healing capabilities, such as diabetic subjects.

Abstract: A retainer for a pneumatic tool and assembly therefor is disclosed. The retainer includes a tool body having an internal surface defining a bore and an external surface having a threaded portion. A retainer cap is used with the tool body and includes an internal surface having a threaded portion adapted to engage the threaded portion of the tool body. An insert having an outer surface is rotatably mounted in the retainer cap. The insert includes an inner surface with a first inner surface portion adapted for conforming with a non-circular lug surface of a tool shank and a second inner surface portion radially offset from the first portion adapted for conforming with the non-circular lug surface.

Abstract: The invention is a pneumatic impact hammer in which the vibrations created in the motor portion of the tool are substantially reduced prior to reaching the tool's handle portion. The motor portion is allowed to move relative to the tool's handle portion and is located within a handle-attached cylindrical housing. Low-friction plastic bearings are located between the motor portion and the surrounding housing. The cycling valve that controls the reciprocating movement of the tool's piston is attached to the motor and receives air from a flexible air inlet tube that is slidably engaged to the motor and is secured to the tool's handle portion.

Abstract: The invention is a safety mechanism for an air-powered tool. The mechanism senses the position of the tool's implement retainer and disables the air flow to the tool's motor if the retainer is not in its locked position. The mechanism employs a pushrod that has one end adapted to contact a rear surface of the retainer when the retainer is in its lock position. The other end of the pushrod is adapted to contact a spring-biased ball-type check valve located within the air inlet to the tool's motor. When the retainer is removed from the tool, the pushrod moves forwardly under the urging of the valve and at the same time allows the valve to move to its closed position to thereby prevent any flow of pressurized air to the motor.

Abstract: There is described an adjustable dose injection pistol comprising a body assembly (1) including an elongate chamber (8), a piston chamber (3) including a piston (13) slideable in the chamber (8) between filled and discharged positions and means for adjusting (16, 26, 19, 20, 22, 23) one of said positions.The means comprise a selectable plurality of channels (20, 22, 23) included in one of the assemblies (1, 3), the channels (20, 22, 23) being spaced about and parallel to the piston-chamber axis, and an arrestor (19) located on the other assembly (1, 3), the arrestor (19) being selectably engageable with an aligned channel (20, 22, 23) upon movement of said piston (13) between said positions.The channels (20, 22, 23) are preferably located in the piston assembly (3) on a sleeve (16) concentrically mounted with the piston (13) and rotable with respect to the chamber (8).The pistol may be used for the injection of liquids into animals.

Abstract: An inhalation device for a powdered medicament contained initially in a container, which device comprises a swirl chamber adapted to receive a medicament container and having air inlets thereinto and a mouthpiece in communication therewith; a container receiving cavity also in communication with said swirl chamber; and piercing means operable to pierce a medicament container when in the cavity and to withdraw from the pierced container, said cavity being provided with obstructive means to prevent the container re-entering the cavity after being pierced.

Abstract: The present invention provides an inhalation device for use with a pressurized container having an outlet valve mechanism and from which material may be discharged by depression of a portion of the valve mechanism thereof, which device comprises a chamber for receiving said container; actuating means adapted to bear on the valve mechanism of the container; and first and second biasing means both adapted to bias the container towards the actuating means, said first and second biasing means each being of insufficient force alone to depress the portion of the valve mechanism of the container but together being of sufficient force to do so, said second biasing means being restrained in a position in which it does not bear on the container and releasable on inhalation through the device to a position in which it does bear on the container.

Abstract: A new form of nerve growth factor having a molecular weight of about 116,000 and which is stable in dilute aqueous solutions is obtained from mouse submandibular gland or mouse saliva. An extract of mouse submandibular gland or mouse saliva is subjected to ion-exchange chromatography to recover a component of the gland or saliva rich in the nerve growth factor and containing proteinaceous material which does not degrade the nerve growth factor. The pure nerve growth factor is obtained by subjecting the component rich in nerve growth factor to at least one additional chromatography step, usually two to four, to recover pure nerve growth factor having a molecular weight of about 116,000.