Abstract: The disclosure provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein W1, W2, Y, Z, M, L, Cy, Cz, R1, R2, R3, R4, R2a, Ry, Rz, and the subscripts m, n, q, and r are as described herein. The compounds or their pharmaceutically acceptable salts can inhibit the G12C mutant of Kirsten rat sarcoma (KRAS) protein and are expected to have utility as therapeutic agents, for example, for treating cancer. The disclosure also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The disclosure also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of cancer and for preparing pharmaceuticals for this purpose.

Abstract: A child safety seat includes a seat shell for receiving a child, an extension member, an extension locking mechanism operable to lock the extension member with respect to the seat shell, and an anti-rebound part. The anti-rebound part can be installed on the extension member or the seat shell. The child safety seat is installable on a vehicle seat in a rear facing position with the anti-rebound part extending at an angle above the extension member and adjacent to a seatback of the vehicle seat.

Abstract: The present invention discloses a child restraint system including a main body and an adjusting foot. The main body includes a seat portion, a backrest portion, a first supporting portion and a second supporting portion. The first supporting portion is located adjacent to a first end of the seat portion away from the backrest portion, and the second supporting portion is located adjacent to a second end of the seat portion connected to the backrest portion. The adjusting foot is movably disposed on the main body and includes a third supporting portion. The first supporting portion and the third supporting portion abut against a vehicle seat to support the child restraint system at a forward facing position on the vehicle seat. The second supporting portion and the third supporting portion abut against the vehicle seat to support the child restraint system at a rearward facing position on the vehicle seat.

Abstract: A molecular diagnostic test device can include a housing and a sample preparation module within the housing. The sample preparation module defines an input reservoir and a sample input opening through which a biological sample can be loaded into the input reservoir. The sample preparation module includes a solid reagent contained within the input reservoir. The molecular diagnostic test device can include a fluid source within the housing. The fluid source is in fluid communication with the input reservoir such that upon activation of the molecular diagnostic test device, the fluid from the fluid source is injected into the input reservoir to mix the biological sample and the solid reagent within the input reservoir to form an input solution containing a target molecule.

Abstract: In some embodiments, an apparatus includes a layer of a printed circuit board (PCB), a pair of signal vias formed on the layer of the PCB and including a first signal via a second signal via each configured to propagate a respective signal, a first plurality of ground vias formed on the layer and at least partially circumferentially surrounding the first signal via of the pair of signal vias, and a second plurality of ground vias formed on the layer and at least partially circumferentially surrounding the second signal via of the pair of signal vias. The first plurality of ground vias and the second plurality of ground vias include a shared ground via.

Abstract: Provided is a noisy channel generative model of two sequences, for example text and speech, which enables uncovering the associations between the two modalities when limited paired data is available. To address the intractability of the exact model under a realistic data set-up, example aspects of the present disclosure include a variational inference approximation. To train this variational model with categorical data, a KL encoder loss approach is proposed which has connections to the wake-sleep algorithm.

Abstract: The present disclosure provides a method of facilitating provisioning of a software functionality. Further, the method may include receiving, using a communication device, an input data from a user device. Further, the method may include generating, using a processing device, an output data based on the input data and a first LLM. Further, the first LLM may be trained on training data corresponding to the software functionality. Further, the training data includes an input training data and an output training data. Further, the output training data may be generated by an implementation of the software functionality based on the input training data. Further, the method may include transmitting, using the communication device, the output data.

Abstract: The present disclosure provides a method of facilitating provisioning of Information Technology infrastructure data. Further, the method may include receiving one or more IT infrastructure data infrastructures from a client device. Further, the method may include analyzing the one or more IT infrastructure data using a first Large Language Model. Further, the first LLM may be trained on a training data comprising an association of two or more IT infrastructure data and two or more IT specification data. Further, the method may include generating one or more IT specification data based on the analyzing. Further, the one or more IT specification data includes a functionality data representing one or more functionalities provided by the one or more IT infrastructures implemented according to the one or more IT specification data. Further, the method may include transmitting the one or more IT specification data to the client device.

Abstract: Described herein, inter alia, are clock activators and uses thereof.

Abstract: A horizontal parallax multiview display employs a plurality of slanted multibeam columns to scatter out of a light guide a plurality of directional light beams having principal angular directions corresponding to different view directions of the horizontal parallax multiview display. The plurality of directional light beams is modulated using an array of light valves to provide a multiview image having horizontal parallax. Further, the horizontal parallax multiview display employs a light control film having a slanted light control axis aligned with slanted multibeam columns of the slanted multibeam column plurality. The light control film is configured to control a view angle of the multiview image in a direction orthogonal to the horizontal parallax. The slanted multibeam columns may provide the multiview displays with a balanced resolution.

Abstract: A passive optical network system having a node that is optically coupled to optical line terminals (OLTs), and that is optically coupled to optical network units (ONUs). The node includes at least one fiber link module (FLM), each FLM including an upstream multiplex conversion device (MCD), and a downstream MCD. The upstream MCD receives an upstream optical signal from the ONUs, converts the upstream optical signal to an upstream electrical signal, and transmits a regenerated upstream optical signal to the OLTs. The downstream MCD receives a downstream optical signal from the OLTs, converts the downstream optical signal to a downstream electrical signal, and transmits a regenerated downstream optical signal to the ONUs.

Abstract: The present disclosure provides a method for facilitating provisioning of software solutions. Further, the method includes obtaining input data. Further, the input data includes natural language input data. Further, the method includes analyzing the input data using each of a prompt model and a large language model. Further, the prompt model is coupled with the large language model. Further, the large language model is trained on a training data. Further, the prompt model interprets input data for generating requirements of the users. Further, the large language model processes the requirements for designing the software solutions. Further, the method includes generating software solution information for the provisioning of software solutions based on the analyzing of the input data. Further, the method includes transmitting the software solution information to devices. Further, the method includes storing the software solution information and each of the prompt model and the large language model.

Abstract: The invention provides new heteroaromatic compounds having the general formula (I?), or a solvate or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, Y1, Y2, Y3, and n are as defined herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

Abstract: Nucleic acid molecules, compositions, recombinant AAV (rAAV) particles, kits, and methods are described herein for delivering a base editor (or “nucleobase editor”) to cells, e.g., via AAV vectors. In particular, the disclosure provides compositions, methods, and uses for delivery of adenine base editors and cytosine base editors in a single AAV vector (or genome). Further described herein are improved AAV vectors containing size-minimized regulatory components that enable, e.g., the packaging of base editors. Provided herein are methods and compositions for delivering base editor proteins to a cell or tissue in a single recombinant AAV (rAAV) vector. Contemplated herein are improved methods and compositions for delivering these base editors in vivo, in a single rAAV particle. Further provided herein are base editors and compositions and cells comprising these base editors.

Abstract: Provided herein are functionalized monoclonal antibodies (mAbs) including antibody fragments covalently linked to a peptide compound through a disulfide linkage. The disulfide linkage is between a cysteine in the Fab region of the antibody or fragment thereof and a thiol moiety of a side chain amino acid of the peptide compound. The covalently formed complexes including provided herein form highly stable and versatile drug delivery and diagnostic compositions.

Abstract: Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data.

Abstract: Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data.

Abstract: In some embodiments, an apparatus, includes a pad of a printed circuit board (PCB) configured to couple to an electrical component separate from the PCB and a via formed through the pad. The via is offset from a center of the pad such that a distance between the via and a most adjacent trace electrically separate from the via is above a threshold distance.

Abstract: Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data.

Abstract: Some implementations herein provide for a memory device and methods of formation. The memory device includes a plurality of storage cells arranged vertically and a plurality of corresponding gate all around transistors. Methods of forming the memory device include using a single trench to remove a liner material and form recesses that define cell contact lightly-doped drain regions of the gate all around transistors. Using the single trench to remove the liner material and form the recesses that define the cell contact lightly-doped drain region widths causes the cell contact lightly-doped drain regions to be formed having substantially similar widths.