Patents by Inventor David Machover

David Machover has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • [6R]-MTHF IN B6 ENHANCED 5-FU BASED CHEMOTHERAPY OF PANCREATIC CANCER
    Publication number: 20240350467
    Abstract: The present invention relates to the treatment of pancreatic cancer, in particular KRAS-mutated pancreatic adenocarcinoma, in human populations employing a dosage regimen which includes arfolitixorin ([6R]-5,10-methylenetetrahydrofolate ([6R]-MTHF) and a B6 vitamin in connection with 5-fluorouracil (5-FU) based chemotherapy.
    Type: Application
    Filed: April 20, 2023
    Publication date: October 24, 2024
    Inventors: Per Lennart Lindberg, David Machover
  • [6R]-MTHF IN B6 ENHANCED 5-FU BASED CHEMOTHERAPY OF CARCINOMA
    Publication number: 20240350495
    Abstract: The present invention relates to the treatment of carcinoma, such as colorectal cancer, in human populations employing a dosage regimen which includes arfolitixorin, i.e. [6R]-5,10-methylenetetrahydrofolate ([6R]-MTHF) and a vitamin B6 in connection with 5-fluorouracil (5-FU) based chemotherapy.
    Type: Application
    Filed: April 20, 2023
    Publication date: October 24, 2024
    Inventors: Per Lennart Lindberg, David Machover
  • Polypeptides isolated from and their use for the treatment of cancer
    Patent number: 9051562
    Abstract: The present invention relates to methods and pharmaceutical compositions for treating cancer. More specifically, the invention relates to a polypeptide isolated from Brevibacterium aurantiacum that shows methionine gamma-lyase and homocysteinase activities. The present invention also relates to the use of such a polypeptide for the treatment of cancer.
    Type: Grant
    Filed: June 15, 2012
    Date of Patent: June 9, 2015
    Assignees: Institut National de la Santé et de la Recherche Médicale (INSERM), INRA (Institut National de la Recherche Agronomique), UNIVERSITE PARIS SUD-PARIS XI
    Inventors: David Machover, Pascal Bonnarme
  • POLYPEPTIDES ISOLATED FROM BREVIBACTERIUM AURANTIACUM AND THEIR USE FOR THE TREATMENT OF CANCER
    Publication number: 20140140978
    Abstract: The present invention relates to methods and pharmaceutical compositions for treating cancer. More specifically, the invention relates to a polypeptide isolated from Brevibacterium aurantiacum that shows methionine gamma-lyase and homocysteinase activities. The present invention also relates to the use of such a polypeptide for the treatment of cancer.
    Type: Application
    Filed: June 15, 2012
    Publication date: May 22, 2014
    Applicants: INSERM (Institut National de la Sante et de la Recherche Medicale), UNIVERSITE PARIS SUD-PARIS XI, INRA (Institut National de la Recherche Agronomique)
    Inventors: David Machover, Pascal Bonnarme