Abstract: The invention provides a method of treating or reducing the severity of thyroid-associated ophthalmopathy (TAO), also known as thyroid eye disease (TED) or Graves' ophthalmopathy or orbitopathy (GO), or a symptom or aspect thereof, in subjects that have undergone prior treatment for TAO, TED, or GO, and either did not respond to said prior treatment or relapsed after said prior treatment. The invention also provides antibodies, or antigen binding fragments thereof, and pharmaceutical compositions useful in the disclosed methods.

Abstract: Disclosed herein is a storage system for storing low latent heat of vaporization gases comprises a primary storage tank for storing a liquid having a latent heat of vaporization of less than or equal to 1000 joules per gram, and a secondary storage tank comprising a porous sorbent for reversibly storing a boil-off gas released from the primary storage tank.

Abstract: A system for generating electricity with reduced or negative carbon emissions. The system includes a power plant section having an electricity generating unit having an input coupled to a hydrocarbon fuel supply and an energy exchange path. The system also includes a direct air capture (DAC) section having a CO2 adsorption device having a CO2 adsorbent material and a ventilator electrically coupled to the electricity generating unit, the ventilator directing air flow through the CO2 adsorption device in a carbon capture mode, wherein the CO2 adsorption device is coupled to and in energy communication with the energy exchange path for releasing adsorbed CO2 in a carbon release mode.

Abstract: A brace for a carpometacarpal joint of a thumb includes a body made of an elastomeric material. The body includes a wrist strap configured to surround a wrist, a dorsal projection extending from the wrist strap, a first palmar strap extending between a proximal end connected to the wrist strap and a distal end configured to removably attach to the dorsal projection, and a second palmar strap extending between a proximal end connected to the wrist strap and a distal end configured to removably attach to the dorsal projection. The brace also includes a heat-moldable insert positioned within the body. The heat-moldable insert is configured so as to be positioned over a CMC joint of the thumb.

Abstract: The invention provides a method of treating or reducing the severity of thyroid-associated ophthalmopathy (TAO), also known as thyroid eye disease (TED) or Graves' ophthalmopathy or orbitopathy (GO), or a symptom or aspect thereof, in subjects that have undergone prior treatment for TAO, TED, or GO, and either did not respond to said prior treatment or relapsed after said prior treatment. The invention also provides antibodies, or antigen binding fragments thereof, and pharmaceutical compositions useful in the disclosed methods.

Abstract: The invention provides a method of reducing the severity of, or treating, thyroid-associated ophthalmopathy (TAO), also known as thyroid eye disease (TED) or Graves' ophthalmopathy or orbitopathy (GO), as well as antibodies, or antigen binding fragments thereof, and pharmaceutical compositions comprising them, useful in the methods.

Abstract: A system for generating electricity with reduced or negative carbon emissions. The system includes a power plant section having an electricity generating unit having an input coupled to a hydrocarbon fuel supply and an energy exchange path. The system also includes a direct air capture (DAC) section having a CO2 adsorption device having a CO2 adsorbent material and a ventilator electrically coupled to the electricity generating unit, the ventilator directing air flow through the CO2 adsorption device in a carbon capture mode, wherein the CO2 adsorption device is coupled to and in energy communication with the energy exchange path for releasing adsorbed CO2 in a carbon release mode.

Abstract: A system for generating electricity with reduced or negative carbon emissions includes a power plant section having an electricity generating unit that includes a solid oxide fuel cell (SOFC) system. The SOFC system includes a SOFC fuel cell reactor and a combustor with an energy exchange path. The combustor is coupled to the fuel cell reactor to combust unutilized fuel. The system also includes a direct air capture (DAC) section having a carbon dioxide (CO2) adsorption device having a CO2 adsorbent material and a ventilator electrically coupled to the electric generator for flowing ambient air through the CO2 adsorption device in a carbon capture mode. The CO2 adsorption device is coupled to and in energy communication with the energy exchange path for releasing adsorbed CO2 in a carbon release mode.

Abstract: Ankle orthoses include a fabric portion having closure flaps, a rigid upright assembly having at least a portion disposed within the fabric portion, and at least one adjustable cuff assembly configured to encircle the lower leg of the wearer above the ankle over the fabric portion and apply medial-lateral force to the lower leg of the wearer, thereby, preventing a tibia and fibula of the wearer from separating. The orthosis includes a first fastener coupled to a side of the orthosis at a position inferior of the ankle joint of the wearer; and a first midfoot strap configured to wrap at least partly around the midfoot of the wearer over the fabric portion and having a first end coupled to the same position on the side of the orthosis as the first fastener, and a second end configured to couple to the first fastener. Additional orthoses and methods are provided.

Abstract: The invention provides a method of reducing the severity of, or treating, thyroid-associated ophthalmopathy (TAO), also known as thyroid eye disease (TED) or Graves' ophthalmopathy or orbitopathy (GO), as well as antibodies, or antigen binding fragments thereof, and pharmaceutical compositions comprising them, useful in the methods.

Abstract: A process of making an adsorbent body, wherein the process includes the steps of: (a) contacting adsorbent material with an initial mixture to form a solvated adsorbent mixture in a first solvent; (b) removing the first solvent and removing at least some of the first solvent from the solvated adsorbent mixture in the first solvent to form an initial adsorbent body; (c) contacting the initial adsorbent body with a second solvent to form a reduced-binder adsorbent body in a second solvent; and (d) solvent-drying the reduced-binder adsorbent body to form the adsorbent body. Also described is an adsorbent body, and the use of the adsorbent body in gas storage.

Abstract: The invention provides a method of reducing the severity of, or treating, thyroid-associated ophthalmopathy (TAO), also known as thyroid eye disease (TED) or Graves' ophthalmopathy or orbitopathy (GO), as well as antibodies, or antigen binding fragments thereof, and pharmaceutical compositions comprising them, useful in the methods.

Abstract: The invention provides a method of reducing the severity of, or treating, thyroid-associated ophthalmopathy (TAO), also known as thyroid eye disease (TED) or Graves' ophthalmopathy or orbitopathy (GO), as well as antibodies, or antigen binding fragments thereof, and pharmaceutical compositions comprising them, useful in the methods.

Abstract: The invention provides a method of treating or reducing the severity of thyroid-associated ophthalmopathy (TAO), also known as thyroid eye disease (TED) or Graves' ophthalmopathy or orbitopathy (GO), as well as antibodies, or antigen binding fragments thereof, and pharmaceutical compositions comprising them, useful in the methods.

Abstract: A brace for a carpometacarpal joint of a thumb includes a body made of an elastomeric material. The body includes a wrist strap configured to surround a wrist, a dorsal projection extending from the wrist strap, a first palmar strap extending between a proximal end connected to the wrist strap and a distal end configured to removably attach to the dorsal projection, and a second palmar strap extending between a proximal end connected to the wrist strap and a distal end configured to removably attach to the dorsal projection. The brace also includes a heat-moldable insert positioned within the body. The heat-moldable insert is configured so as to be positioned over a CMC joint of the thumb.

Abstract: A brace for a carpometacarpal joint of a thumb includes a body made of an elastomeric material. The body includes a wrist strap configured to surround a wrist, a dorsal projection extending from the wrist strap, a first palmar strap extending between a proximal end connected to the wrist strap and a distal end configured to removably attach to the dorsal projection, and a second palmar strap extending between a proximal end connected to the wrist strap and a distal end configured to removably attach to the dorsal projection. The brace also includes a heat-moldable insert positioned within the body. The heat-moldable insert is configured so as to be positioned over a CMC joint of the thumb.

Abstract: A brace for a carpometacarpal joint of a thumb includes a body made of an elastomeric material. The body includes a wrist strap configured to surround a wrist, a dorsal projection extending from the wrist strap, a first palmar strap extending between a proximal end connected to the wrist strap and a distal end configured to removably attach to the dorsal projection, and a second palmar strap extending between a proximal end connected to the wrist strap and a distal end configured to removably attach to the dorsal projection. The brace also includes a heat-moldable insert positioned within the body. The heat-moldable insert is configured so as to be positioned over a CMC joint of the thumb.

Abstract: The invention provides a method of treating or reducing the severity of thyroid-associated ophthalmopathy (TAO), also known as thyroid eye disease (TED) or Graves' ophthalmopathy or orbitopathy (GO), or a symptom or aspect thereof, in subjects that have undergone prior treatment for TAO, TED, or GO, and either did not respond to said prior treatment or relapsed after said prior treatment. The invention also provides antibodies, or antigen binding fragments thereof, and pharmaceutical compositions useful in the disclosed methods.

Abstract: The invention provides a method of reducing the severity of, or treating, thyroid-associated ophthalmopathy (TAO), also known as thyroid eye disease (TED) or Graves' ophthalmopathy or orbitopathy (GO), as well as antibodies, or antigen binding fragments thereof, and pharmaceutical compositions comprising them, useful in the methods.

Abstract: A moldable rigid ankle brace is disclosed. The rigid stabilizing ankle brace includes a heat-moldable multi-layer housing having an opening for receiving a user's ankle, a footplate attached to the housing, and a closure mechanism. The multi-layer housing includes a middle layer, which is substantially stiff at a temperature below about 130° F. and moldable at temperatures between about 130° F. and 275° F. A method of stabilizing an ankle is also disclosed. The method may include providing a rigid stabilizing ankle brace, having a heat-moldable multi-layer housing having an opening for receiving a user's ankle, and a footplate removably attached to said housing, heating the ankle brace to between about 130° F. to about 275° F., and applying said heated ankle brace to the ankle of a patient in need thereof.