Patents by Inventor David Malcolm Crowe

David Malcolm Crowe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Solid forms of an eIF4E inhibitor
    Patent number: 12655161
    Abstract: The present invention relates to solid forms of 7-(5-chloro-2-(3-(5-cyano-6-((1-(3,3-difluorocyclobutyl)piperidin-4-yl)(methyl)amino)-2-methyl-4-oxopyrido[3,4-d]pyrimidin-3(4H)-yl)prop-1-yn-1-yl)phenyl)-N-(methylsulfonyl)thieno[3,2-b]pyridine-3-carboxamide, to pharmaceutical compositions comprising such solid forms, and to methods of using such solid forms and pharmaceutical compositions for the treatment of cancer.
    Type: Grant
    Filed: December 22, 2021
    Date of Patent: June 16, 2026
    Assignees: Pfizer Inc., eFFECTOR Therapeutics Inc.
    Inventors: Kapildev Kashmirilal Arora, Wesley Dewitt Clark, David Malcolm Crowe, Jason Gray
  • Acid addition salts of piperazine derivatives
    Patent number: 12398130
    Abstract: The invention relates to acid addition salts of piperazine derivatives, as well as solid forms, such as polymorphic forms, thereof, which are useful as pharmaceutical ingredients and, in particular, as glycosidase inhibitors.
    Type: Grant
    Filed: December 6, 2022
    Date of Patent: August 26, 2025
    Assignee: Asceneuron SA
    Inventors: Anna Quattropani, Santosh S. Kulkarni, Awadut Gajendra Giri, Dawn V. Toronto, David Malcolm Crowe
  • Succinate and fumarate acid addition salts of piperazine derivatives
    Patent number: 12195455
    Abstract: The invention relates to succinic acid addition salts or fumaric acid addition salts of piperazine derivatives of formula (I), as well as solid forms, such as polymorphic forms, thereof, which are useful as pharmaceutical ingredients and, in particular, as glycosidase inhibitors.
    Type: Grant
    Filed: August 22, 2019
    Date of Patent: January 14, 2025
    Assignee: Asceneuron SA
    Inventors: Anna Quattropani, Santosh S. Kulkarni, Awadut Gajendra Giri, Robert Hett, David Malcolm Crowe
  • POLYMORPHS OF N-[(3-FLUORO-4-METHOXYPYRIDIN-2-YL)METHYL]-3-(METHOXYMETHYL)-1-({4-[(2-OXOPYRIDIN-1-YL)METHYL]PHENYL}METHYL)PYRAZOLE-4-CARBOXAMIDE AND SALTS THEREOF
    Publication number: 20240199573
    Abstract: The invention provides new polymorphs of N-[(3-fluoro-4-methoxypyridin-2-yl)methyl]-3-(methoxymethyl)-1-({4-[(2-oxopyridin-1-yl)methyl]phenyl}methyl)pyrazole-4-carboxamide and salts thereof, pharmaceutical compositions containing them and their use in therapy.
    Type: Application
    Filed: July 6, 2023
    Publication date: June 20, 2024
    Inventors: Haydn BEATON, David Malcolm CROWE, Hannah Joy EDWARDS
  • Solid Forms of an eIF4E Inhibitor
    Publication number: 20240076301
    Abstract: The present invention relates to solid forms of 7-(5-chloro-2-(3-(5-cyano-6-(1-(3,3-difluorocyclobutyl)piperidin-4-yl)(methyl)amino)-2-methyl-4-oxopyrido[3,4-d]pyrimidin-3(4H)-yl)prop-1-yn-1-yl)phenyl)-N-(methylsulfonyl)thieno[3,2-b]pyridine-3-carboxamide, to pharmaceutical compositions comprising such solid forms, and to methods of using such solid forms and pharmaceutical compositions for the treatment of cancer.
    Type: Application
    Filed: December 22, 2021
    Publication date: March 7, 2024
    Inventors: Kapildev Kashmirilal Arora, Wesley Dewitt Clark, David Malcolm Crowe, Jason Gray
  • Polymorphs of N-[(3-fluoro-4-methoxypyridin-2-yl)methyl]-3-(methoxymethyl)-1-({4-[(2-oxopyridin-1-yl)methyl]phenyl}methyl)pyrazole-4-carboxamide and salts thereof
    Patent number: 11739068
    Abstract: The invention provides new polymorphs of N-[(3-fluoro-4-methoxypyridin-2-yl)methyl]-3 -(methoxymethyl)-1-({4-[(2-oxopyridin-1-yl)methyl]phenyl}methyl)pyrazole-4-carboxamide and salts thereof, pharmaceutical compositions containing them and their use in therapy.
    Type: Grant
    Filed: October 20, 2021
    Date of Patent: August 29, 2023
    Assignee: KalVista Pharmaceuticals Limited
    Inventors: Haydn Beaton, David Malcolm Crowe, Hannah Joy Edwards
  • SOLID FORMS OF A PLASMA KALLIKREIN INHIBITOR AND SALTS THEREOF
    Publication number: 20230203012
    Abstract: New solid forms of the plasma kallikrein inhibitor, 1-({4-[(5-fluoro-2-oxopyridin yl)methyl]phenyl}methyl)-N-[(3-fluoro-4-methoxypyridin-2-yl)methyl]-3-(methoxymethyl)pyrazole carboxamide and its salts, are described.
    Type: Application
    Filed: February 17, 2023
    Publication date: June 29, 2023
    Inventor: David Malcolm CROWE
  • ACID ADDITION SALTS OF PIPERAZINE DERIVATIVES
    Publication number: 20230120169
    Abstract: The invention relates to acid addition salts of piperazine derivatives, as well as solid forms, such as polymorphic forms, thereof, which are useful as pharmaceutical ingredients and, in particular, as glycosidase inhibitors.
    Type: Application
    Filed: December 6, 2022
    Publication date: April 20, 2023
    Inventors: Anna QUATTROPANI, Santosh S. KULKARNI, Awadut Gajendra GIRI, Dawn V. TORONTO, David Malcolm CROWE
  • Acid addition salts of piperazine derivatives
    Patent number: 11591327
    Abstract: The invention relates to acid addition salts of piperazine derivatives, as well as solid forms, such as polymorphic forms, thereof, which are useful as pharmaceutical ingredients and, in particular, as glycosidase inhibitors.
    Type: Grant
    Filed: May 18, 2020
    Date of Patent: February 28, 2023
    Assignee: Asceneuron SA
    Inventors: Anna Quattropani, Santosh S. Kulkarni, Awadut Gajendra Giri, Dawn V. Toronto, David Malcolm Crowe
  • Solid forms of a plasma kallikrein inhibitor and salts thereof
    Patent number: 11584735
    Abstract: New solid forms of the plasma kallikrein inhibitor, 1-({4-[(5-fluoro-2-oxopyridin-1-yl)methyl]phenyl}methyl)-N-[(3-fluoro-4-methoxypyridin-2-yl)methyl]-3-(methoxymethyl)pyrazole-4-carboxamide and its salts, are described.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: February 21, 2023
    Assignee: KalVista Pharmaceuticals Limited
    Inventors: David Malcolm Crowe, Edwin Aret, Kiran Gandhi, Ruben Henricus Carolus Adrianus Titus Lelieveld, Emma Kay Sharp, Richard Simon Todd
  • POLYMORPHS OF N-[(3-FLUORO-4-METHOXYPYRIDIN-2-YL)METHYL]-3-(METHOXYMETHYL)-1-({4-[(2-OXOPYRIDIN-1-YL)METHYL]PHENYL}METHYL)PYRAZOLE-4-CARBOXAMIDE AND SALTS THEREOF
    Publication number: 20220041571
    Abstract: The invention provides new polymorphs of N-[(3-fluoro-4-methoxypyridin-2-yl)methyl]-3-(methoxymethyl)-1-({4-[(2-oxopyridin-1-yl)methyl]phenyl}methyl)pyrazole-4-carboxamide and salts thereof, pharmaceutical compositions containing them and their use in therapy.
    Type: Application
    Filed: October 20, 2021
    Publication date: February 10, 2022
    Inventors: Haydn BEATON, David Malcolm CROWE, Hannah Joy EDWARDS
  • Polymorphs of n-[(3-fluoro-4-methoxypyridin-2-yl)methyl]-3-(methoxymethyl)-1-({4-[2-oxopyridin-1-yl)methyl]phenyl} methyl)pyrazole-4-carboxamide as iallikrein inhibitors
    Patent number: 11230537
    Abstract: The invention provides new polymorphs of N-[(3-fluoro-4-methoxypyridin-2-yl)methyl]-3-(methoxymethyl)-1-({4-[(2-oxopyridin-1-yl)methyl]phenyl}methyl)pyrazole-4-carboxamide and salts thereof, pharmaceutical compositions containing them and their use as kallikrein inhibitors in therapy.
    Type: Grant
    Filed: June 1, 2017
    Date of Patent: January 25, 2022
    Assignee: KalVista Pharmaceuticals Limited
    Inventors: Haydn Beaton, David Malcolm Crowe, Hannah Joy Edwards, Nicholas James Griffiths-Haynes
  • SUCCINATE AND FUMARATE ACID ADDITION SALTS OF PIPERAZINE DERIVATIVES
    Publication number: 20210198250
    Abstract: The invention relates to succinic acid addition salts or fumaric acid addition salts of piperazine derivatives of formula (I), as well as solid forms, such as polymorphic forms, thereof, which are useful as pharmaceutical ingredients and, in particular, as glucosidase inhibitors.
    Type: Application
    Filed: August 22, 2019
    Publication date: July 1, 2021
    Inventors: Anna QUATTROPANI, Santosh S. KULKARNI, Awadut Gajendra GIRI, Robert HETT, David Malcolm CROWE
  • SOLID FORMS OF A PLASMA KALLIKREIN INHIBITOR AND SALTS THEREOF
    Publication number: 20210171496
    Abstract: New solid forms of the plasma kallikrein inhibitor, 1-({4-[(5-fluoro-2-oxopyridin-1-yl)methyl]phenyl}methyl)-N-[(3-fluoro-4-methoxypyridin-2-yl)methyl]-3-(methoxymethyl)pyrazole-4-carboxamide and its salts, are described.
    Type: Application
    Filed: November 29, 2018
    Publication date: June 10, 2021
    Inventors: David Malcolm CROWE, Stephen Mark MACDONALD-BROWN, Edwin ARET, Kiran GANDHI, Ruben Henricus Carolus Adrianus Titus LELIEVELD, Emma Kay SHARP, Richard Simon TODD
  • ACID ADDITION SALTS OF PIPERAZINE DERIVATIVES
    Publication number: 20200385375
    Abstract: The invention relates to acid addition salts of piperazine derivatives, as well as solid forms, such as polymorphic forms, thereof, which are useful as pharmaceutical ingredients and, in particular, as glycosidase inhibitors.
    Type: Application
    Filed: May 18, 2020
    Publication date: December 10, 2020
    Applicant: Asceneuron SA
    Inventors: Anna QUATTROPANI, Santosh S. KULKARNI, Awadut Gajendra GIRI, Dawn V. TORONTO, David Malcolm CROWE
  • SOLID FORMS OF A PLASMA KALLIKREIN INHIBITOR AND SALTS THEREOF
    Publication number: 20200325116
    Abstract: The present invention relates to new solid forms of a plasma kallikrein inhibitor, a pharmaceutical composition containing them and their use in therapy. Also provided are processes for preparing the solid forms of the present invention.
    Type: Application
    Filed: November 29, 2018
    Publication date: October 15, 2020
    Inventors: David Malcolm CROWE, David Michael EVANS
  • POLYMORPHS OF N-[(2,6-DIFLUORO-3-METHOXYPHENYL)METHYL]-3-(METHOXYMETHYL)-1-({4-[(2-OXOPYRIDIN-1YL)METHYL]PHENYL}METHYL)PYRAZOLE-4-CARBOXAMIDE
    Publication number: 20200317639
    Abstract: The invention provides new polymorphs of N-[(2,6-difluoro-3-methoxyphenyl)methyl]-3-(methoxymethyl)-1-({4-[(2-oxopyridin-1-yl)methyl]phenyl}methyl)pyrazole-4-carboxamide, pharmaceutical compositions containing them and their use in therapy.
    Type: Application
    Filed: May 31, 2017
    Publication date: October 8, 2020
    Inventors: David Malcolm CROWE, Melvyn Edward GILES
  • POLYMORPHS OF N-[(3-FLUORO-4-METHOXYPYRIDIN-2-YL)METHYL]-3-(METHOXYMETHYL)-1 -({4-[2-OXOPYRIDIN-1-YL)METHYL]PHENYL} METHYL)PYRAZOLE-4-CARBOXAMIDE AS IALLIKREIN INHIBITORS
    Publication number: 20200317633
    Abstract: The invention provides new polymorphs of N-[(3-fluoro-4-methoxypyridin-2-yl)methyl]-3-(methoxymethyl)-1-({4-[(2-oxopyridin-1-yl)methyl]phenyl}methyl)pyrazole-4-carboxamide and salts thereof, pharmaceutical compositions containing them and their use as kallikrein inhibitors in therapy
    Type: Application
    Filed: June 1, 2017
    Publication date: October 8, 2020
    Inventors: Haydn BEATON, David Malcolm CROWE, Hannah Joy EDWARDS, Nicholas James GRIFFITHS-HAYNES
  • Polymorphs of N-[(6-cyano-2-fluoro)-3-methoxyphenyl)methyl]-3-(methoxymethyl)-1-({4-[(2-oxopyridin-1-yl)methyl]phenyl}methyl)pyrazole-4-carboxamide as kallikrein inhibitors
    Patent number: 10752607
    Abstract: The invention provides new polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)methyl]-3-(methoxymethyl)-1-({4-[(2-oxopyridin-1-yl)methyl]phenyl}methyl)pyrazole-4-carboxamide, pharmaceutical compositions containing them and their use in therapy.
    Type: Grant
    Filed: June 1, 2017
    Date of Patent: August 25, 2020
    Assignee: KALVISTA PHARMACEUTICALS LIMITED
    Inventors: Haydn Beaton, Jonathan Yates Boxhall, David Malcolm Crowe
  • Acid addition salts of piperazine derivatives
    Patent number: 10696668
    Abstract: The invention relates to acid addition salts of piperazine derivatives, as well as solid forms, such as polymorphic forms, thereof, which are useful as pharmaceutical ingredients and, in particular, as glycosidase inhibitors.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: June 30, 2020
    Assignee: Asceneuron SA
    Inventors: Anna Quattropani, Santosh S. Kulkarni, Awadut Gajendra Giri, Dawn V. Toronto, David Malcolm Crowe