Patents by Inventor David Mandelman

David Mandelman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SSB-polymerase fusion proteins
    Patent number: 9580743
    Abstract: Fusion proteins comprising a single strand DNA binding protein and a nucleic acid polymerase (e.g. DNA polymerase or reverse transcriptase). These high fidelity proteins are suitable for use in nucleic acid amplification methods, including the polymerase chain reaction (PCR).
    Type: Grant
    Filed: August 4, 2014
    Date of Patent: February 28, 2017
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Jun Lee, Robert Potter, David Mandelman
  • MUTANT DNA POLYMERASE BLENDS AND MUTANT DNA POLYMERASES
    Publication number: 20160272955
    Abstract: A thermostable DNA polymerase composition comprising at least two DNA polymerases, one of which is substantially reduced in 5?-exonuclease activity and one of which has 5?-exonuclease activity. This polymerase may be used in methods including, but not limited to, nucleic acid synthesis, DNA sequencing, nucleic acid amplification and cDNA synthesis.
    Type: Application
    Filed: June 3, 2016
    Publication date: September 22, 2016
    Inventors: Weidong ZHENG, Jun Lee, Robert Potter, David Mandelman
  • Mutant DNA polymerases
    Patent number: 9376698
    Abstract: An isolated mutant Tfi DNA polymerase having a D144A point mutation. This polymerase may be used in methods including, but not limited to, nucleic acid synthesis, DNA sequencing, nucleic acid amplification and cDNA synthesis.
    Type: Grant
    Filed: March 20, 2008
    Date of Patent: June 28, 2016
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Weidong Zheng, Jun E. Lee, Robert Jason Potter, David Mandelman
  • SSB-POLYMERASE FUSION PROTEINS
    Publication number: 20140377810
    Abstract: Fusion proteins comprising a single strand DNA binding protein and a nucleic acid polymerase (e.g. DNA polymerase or reverse transcriptase). These high fidelity proteins are suitable for use in nucleic acid amplification methods, including the polymerase chain reaction (PCR).
    Type: Application
    Filed: August 4, 2014
    Publication date: December 25, 2014
    Inventors: Jun LEE, Robert Potter, David Mandelman
  • SSB-polymerase fusion proteins
    Patent number: 8828700
    Abstract: Fusion proteins comprising a single strand DNA binding protein and a nucleic acid polymerase (e.g. DNA polymerase or reverse transcriptase). These high fidelity proteins are suitable for use in nucleic acid amplification methods, including the polymerase chain reaction (PCR).
    Type: Grant
    Filed: December 1, 2008
    Date of Patent: September 9, 2014
    Assignee: Life Technologies Corporation
    Inventors: Jun Lee, Robert Potter, David Mandelman
  • SSB-POLYMERASE FUSION PROTEINS
    Publication number: 20100075382
    Abstract: Fusion proteins comprising a single strand DNA binding protein and a nucleic acid polymerase (e.g. DNA polymerase or reverse transcriptase). These high fidelity proteins are suitable for use in nucleic acid amplification methods, including the polymerase chain reaction (PCR).
    Type: Application
    Filed: December 1, 2008
    Publication date: March 25, 2010
    Applicant: INVITROGEN CORPORATION
    Inventors: Jun E. Lee, Robert J. Potter, David Mandelman
  • DNA Polymerase Blends and Mutant DNA Polymerases
    Publication number: 20080254525
    Abstract: A thermostable DNA polymerase composition comprising at least two DNA polymerases, one of which is substantially reduced in 5?-exonuclease activity and one of which has 5?-exonuclease activity.
    Type: Application
    Filed: March 20, 2008
    Publication date: October 16, 2008
    Applicant: INVITROGEN CORPORATION
    Inventors: Weidong Zheng, Jun E. Lee, Robert Jason Potter, David Mandelman
  • SSB-DNA polymerase fusion proteins
    Publication number: 20070059713
    Abstract: Fusion proteins comprising a single strand DNA binding protein and a nucleic acid polymerase (e.g. DNA polymerase or reverse transcriptase). These high fidelity proteins are suitable for use in nucleic acid amplification methods, including the polymerase chain reaction (PCR).
    Type: Application
    Filed: September 9, 2005
    Publication date: March 15, 2007
    Inventors: Jun Lee, Robert Potter, David Mandelman
  • DNA polymerase blends and mutant DNA polymerases
    Publication number: 20060292578
    Abstract: A thermostable DNA polymerase composition comprising at least two DNA polymerases, one of which is substantially reduced in 5?-exonuclease activity and one of which has 5?-exonuclease activity.
    Type: Application
    Filed: June 28, 2005
    Publication date: December 28, 2006
    Inventors: Weidong Zheng, Jun Lee, Robert Potter, David Mandelman