Patents by Inventor David Maresca

David Maresca has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11944848
    Abstract: The system and process of therapeutic and effective cavitation by using ultrasound to collapse gas vesicles as well as cavitate the bubbles produced from the collapsed gas vesicles. Therapeutic effect includes, but is not limited to lysing cells by cavitation. The cells expressing the gas vesicles can optionally be used as delivery cells to preform tasks such as transporting the gas vesicles into deep tissue areas, releasing compounds at the cavitation site, and more. The gas vesicles can optionally be modified to facilitate getting the bubbles near the cavitation targets by functionalizing the gas vesicles.
    Type: Grant
    Filed: July 29, 2022
    Date of Patent: April 2, 2024
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Avinoam D. Bar-Zion, Atousa Nourmahnad, David Maresca, Mikhail Shapiro
  • Publication number: 20230139561
    Abstract: The system and process of therapeutic and effective cavitation by using ultrasound to collapse gas vesicles as well as cavitate the bubbles produced from the collapsed gas vesicles. Therapeutic effect includes, but is not limited to lysing cells by cavitation. The cells expressing the gas vesicles can optionally be used as delivery cells to preform tasks such as transporting the gas vesicles into deep tissue areas, releasing compounds at the cavitation site, and more. The gas vesicles can optionally be modified to facilitate getting the bubbles near the cavitation targets by functionalizing the gas vesicles.
    Type: Application
    Filed: July 29, 2022
    Publication date: May 4, 2023
    Inventors: Avinoam D. BAR-ZION, Atousa NOURMAHNAD, David MARESCA, Mikhail SHAPIRO
  • Patent number: 11446523
    Abstract: The system and process of therapeutic and effective cavitation by using ultrasound to collapse gas vesicles as well as cavitate the bubbles produced from the collapsed gas vesicles. Therapeutic effect includes, but is not limited to lysing cells by cavitation. The cells expressing the gas vesicles can optionally be used as delivery cells to preform tasks such as transporting the gas vesicles into deep tissue areas, releasing compounds at the cavitation site, and more. The gas vesicles can optionally be modified to facilitate getting the bubbles near the cavitation targets by functionalizing the gas vesicles.
    Type: Grant
    Filed: March 29, 2020
    Date of Patent: September 20, 2022
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Avinoam D. Bar-Zion, Atousa Nourmahnad, David Maresca, Mikhail Shapiro
  • Patent number: 11350909
    Abstract: Certain embodiments pertain to cross-amplitude modulation (xAM) ultrasound imaging methods and systems configured to excite a first subaperture of transducer elements to transmit a first ultrasound plane wave, excite a second subaperture of transducer elements to transmit a second ultrasound plane wave noncollinear to the first ultrasound plane wave, the second ultrasound plane wave axisymmetric to the first ultrasound plane wave about a bisector, and simultaneously excite both first and second subapertures to transmit first and second ultrasound plane waves to cause an acoustic pressure above a threshold along the bisector.
    Type: Grant
    Filed: April 17, 2019
    Date of Patent: June 7, 2022
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: David Maresca, Daniel P. Sawyer, Mikhail Shapiro
  • Publication number: 20210353439
    Abstract: Methods and systems are provided for decoding movement intentions using functional ultrasound (fUS) imaging of the brain. In one example, decoding movement intentions include determining a memory phase of a cognitive state of the brain, the memory phase between a gaze fixation phase and movement execution phase, and determining one or more movement intentions including one or more of intended effector (e.g., hand, eye) and intended direction (e.g., right, left) according to a machine learning algorithm trained to classify one or more movement intentions simultaneously.
    Type: Application
    Filed: May 12, 2021
    Publication date: November 18, 2021
    Applicants: California Institute of Technology, INSERM (Institut National de la Santé et de la Recherche Médicale), CNRS-CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris
    Inventors: Sumner L Norman, David Maresca, Vasileios Christopoulos, Mikhail Shapiro, Richard A. Andersen, Mickael Tanter, Charlie Demene
  • Publication number: 20200306564
    Abstract: The system and process of therapeutic and effective cavitation by using ultrasound to collapse gas vesicles as well as cavitate the bubbles produced from the collapsed gas vesicles. Therapeutic effect includes, but is not limited to lysing cells by cavitation. The cells expressing the gas vesicles can optionally be used as delivery cells to preform tasks such as transporting the gas vesicles into deep tissue areas, releasing compounds at the cavitation site, and more. The gas vesicles can optionally be modified to facilitate getting the bubbles near the cavitation targets by functionalizing the gas vesicles.
    Type: Application
    Filed: March 29, 2020
    Publication date: October 1, 2020
    Inventors: Avinoam D. BAR-ZION, Atousa NOURMAHNAD, David MARESCA, Mikhail SHAPIRO
  • Publication number: 20190314001
    Abstract: Certain embodiments pertain to cross-amplitude modulation (xAM) ultrasound imaging methods and systems.
    Type: Application
    Filed: April 17, 2019
    Publication date: October 17, 2019
    Inventors: David Maresca, Daniel P. Sawyer, Mikhail Shapiro
  • Publication number: 20120022375
    Abstract: The present invention relates to an acoustic device for ultrasonic imaging of an object (21). The device comprises an acoustic transducer (10 and an acoustic lens (20) arranged to variably refract the said acoustic pulse to and/or from the acoustic transducer. The acoustic lens comprising a first (L1) and a second fluid (L2) being separated by an acoustic interface (7), the normal of the said acoustic interface forming a relative angle of incidence (AI) with the said acoustic pulse, e.g. an electrowetting lens. The first and the second fluid of the acoustic lens (20) are specifically chosen so that the acoustic interface (7) has a reflection minima at a non-zero relative angle of incidence (AI). The invention is advantageous for obtaining an improved acoustic device having a substantially lower reflection in a broader interval of incidence angles as compared to hitherto seen ultrasonic imaging utilising acoustic lenses with two or more fluids as the active acoustic refracting entities.
    Type: Application
    Filed: January 25, 2010
    Publication date: January 26, 2012
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventors: Szabolcs Deladi, Jan Frederik Suijver, David Maresca