Patents by Inventor David Martin Kaye
David Martin Kaye has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11331274Abstract: The present invention relates to oral controlled-release formulations of 5-(pyridinyl)-2(1H)-pyridinone compounds and their use in the treatment of a subject with heart failure, a stage, class or manifestation of heart failure, or at risk of developing or exhibiting symptoms of heart failure. The formulations of the invention release the compounds in the range of between 0.1 ?g/kg body weight/minute and 20 ?g/kg body weight/minute.Type: GrantFiled: January 17, 2020Date of Patent: May 17, 2022Assignee: Baker Heart and Diabetes InstituteInventors: David Martin Kaye, Guy Krippner, Geetha Thanga Mariappan
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Patent number: 10736853Abstract: The present invention relates to oral controlled-release formulations of 5-(pyridinyl)-2(1H)-pyridinone compounds and their use in the treatment of a subject with heart failure, a stage, class or manifestation of heart failure, or at risk of developing or exhibiting symptoms of heart failure. The formulations of the invention release the compounds in the range of between 0.1 ?g/kg body weight/minute and 20 ?g/kg body weight/minute.Type: GrantFiled: November 20, 2018Date of Patent: August 11, 2020Assignee: Cardiora Pty Ltd.Inventors: David Martin Kaye, Guy Krippner, Geetha Thanga Mariappan
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Publication number: 20200146992Abstract: The present invention relates to oral controlled-release formulations of 5-(pyridinyl)-2(1H)-pyridinone compounds and their use in the treatment of a subject with heart failure, a stage, class or manifestation of heart failure, or at risk of developing or exhibiting symptoms of heart failure. The formulations of the invention release the compounds in the range of between 0.1 ?g/kg body weight/minute and 20 ?g/kg body weight/minute.Type: ApplicationFiled: January 17, 2020Publication date: May 14, 2020Inventors: David Martin Kaye, Guy Krippner, Geetha Thanga Mariappan
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Patent number: 10537527Abstract: The present invention relates to oral controlled-release formulations of 5-(pyridinyl)-2(1H)-pyridinone compounds and their use in the treatment of a subject with heart failure, a stage, class or manifestation of heart failure, or at risk of developing or exhibiting symptoms of heart failure. The formulations of the invention release the compounds in the range of between 0.1 ?g/kg body weight/minute and 20 ?g/kg body weight/minute.Type: GrantFiled: November 20, 2018Date of Patent: January 21, 2020Assignee: Cardiora Pty Ltd.Inventors: David Martin Kaye, Guy Krippner, Geetha Thanga Mariappan
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Patent number: 10517833Abstract: The present invention relates to oral controlled-release formulations of 5-(pyridinyl)-2(1H)-pyridinone compounds and their use in the treatment of a subject with heart failure, a stage, class or manifestation of heart failure, or at risk of developing or exhibiting symptoms of heart failure. The formulations of the invention release the compounds in the range of between 0.1 ?g/kg body weight/minute and 20 ?g/kg body weight/minute.Type: GrantFiled: July 6, 2018Date of Patent: December 31, 2019Assignee: Cardiora Pty Ltd.Inventors: David Martin Kaye, Guy Krippner, Geetha Thanga Mariappan
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Patent number: 10366090Abstract: In one embodiment, a method includes accessing, from a data store of the communication network, user information associated with a first user of the communication network, identifying one or more entities associated with the communication network that are relevant to the first user based on the user information, and retrieving, for each identified entity, one or more content frames associated with the entity. The method includes ranking the one or more content frames based on the user information. The method also includes sending, to a client device of the first user, one or more of the content frames for display to the first user in ranked order, wherein each content frame is selectable by the first user to display the selected content frame in association with a particular content item for a specified period of time.Type: GrantFiled: March 30, 2016Date of Patent: July 30, 2019Assignee: Facebook, Inc.Inventors: Aigerim Shorman, Ben Chen, Jeremy Samuel Friedland, Alan Thomas Clark, Ryan Michael Houx, Xiao Yang Xie, Xiaoyi Zhang, Rahul Rajagopalan, Adam Ankenmann, Mitchell Sadao Fukumoto, Noah Bradley Blecher, Adam Shih, Jing Chen, David Martin Kaye, Crystal Rhan-Tsor Chen
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Publication number: 20190091156Abstract: The present invention relates to oral controlled-release formulations of 5-(pyridinyl)-2(1H)-pyridinone compounds and their use in the treatment of a subject with heart failure, a stage, class or manifestation of heart failure, or at risk of developing or exhibiting symptoms of heart failure. The formulations of the invention release the compounds in the range of between 0.1 ?g/kg body weight/minute and 20 ?g/kg body weight/minute.Type: ApplicationFiled: November 20, 2018Publication date: March 28, 2019Inventors: David Martin Kaye, Guy Krippner, Geetha Thanga Mariappan
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Patent number: 10137093Abstract: The present invention relates to oral controlled-release formulations of 5-(pyridinyl)-2(1H)-pyridinone compounds and their use in the treatment of a subject with heart failure, a stage, class or manifestation of heart failure, or at risk of developing or exhibiting symptoms of heart failure. The formulations of the invention release the compounds in the range of between 0.1 ?g/kg body weight/minute and 20 ?g/kg body weight/minute.Type: GrantFiled: August 16, 2012Date of Patent: November 27, 2018Assignee: Cardiora Pty Ltd.Inventors: David Martin Kaye, Guy Krippner, Geetha Thanga Mariappan
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Publication number: 20180325826Abstract: The present invention relates to oral controlled-release formulations of 5-(pyridinyl)-2(1H)-pyridinone compounds and their use in the treatment of a subject with heart failure, a stage, class or manifestation of heart failure, or at risk of developing or exhibiting symptoms of heart failure. The formulations of the invention release the compounds in the range of between 0.1 ?g/kg body weight/minute and 20 ?g/kg body weight/minute.Type: ApplicationFiled: July 6, 2018Publication date: November 15, 2018Inventors: David Martin Kaye, Guy Krippner, Geetha Thanga Mariappan
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Patent number: 9968759Abstract: The present invention provides devices and methods for use in the perfusion of organs and anatomical regions. In one aspect the present method provides a percutaneously deliverable device for supporting a vessel in a human or animal subject including means for supporting the vessel during delivery of a fluid thereto or collection of a fluid therefrom. In another aspect the invention provides a method for delivery or collection of a fluid to or from an organ or anatomical region in a human or animal subject, the method including the step of supporting a vessel associated with the organ or anatomical region. The devices and methods may be used to deliver, remove or recirculate a therapeutic agent to an organ or anatomical region.Type: GrantFiled: October 13, 2015Date of Patent: May 15, 2018Assignee: OSPREY MEDICAL. INC.Inventors: John Melmouth Power, Mark L. Mathis, David Martin Kaye, Adam Lucas Bilney
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Publication number: 20170319773Abstract: A method of delivering a medicament to a limb of a patient body includes isolating a circulatory system of the limb from a circulatory system of the patient body, wherein the limb circulatory system is substantially all limb arteries and substantially all limb veins located between an isolation region and an end of the limb. A perfusion catheter is inserted into a limb artery in an antegrade position, while a collection catheter is inserted into a limb vein in a retrograde position. The blood flow of the limb circulatory system is then circulated by collecting the blood flow with the collection catheter and delivering the blood flow with the perfusion catheter. A medicament is perfused into the limb circulatory system with the perfusion catheter.Type: ApplicationFiled: January 13, 2017Publication date: November 9, 2017Applicant: Osprey Medical, Inc.Inventor: David Martin Kaye
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Publication number: 20170286423Abstract: In one embodiment, a method includes accessing, from a data store of the communication network, user information associated with a first user of the communication network, identifying one or more entities associated with the communication network that are relevant to the first user based on the user information, and retrieving, for each identified entity, one or more content frames associated with the entity. The method includes ranking the one or more content frames based on the user information. The method also includes sending, to a client device of the first user, one or more of the content frames for display to the first user in ranked order, wherein each content frame is selectable by the first user to display the selected content frame in association with a particular content item for a specified period of time.Type: ApplicationFiled: March 30, 2016Publication date: October 5, 2017Inventors: Aigerim Shorman, Ben Chen, Jeremy Samuel Friedland, Alan Thomas Clark, Ryan Michael Houx, Xiao Yang Xie, Xiaoyi Zhang, Rahul Rajagopalan, Adam Ankenmann, Mitchell Sadao Fukumoto, Noah Bradley Blecher, Adam Shih, Jing Chen, David Martin Kaye, Crystal Rhan-Tsor Chen
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Patent number: 9555183Abstract: A method of delivering a medicament to a limb of a patient body includes isolating a circulatory system of the limb from a circulatory system of the patient body, wherein the limb circulatory system is substantially all limb arteries and substantially all limb veins located between an isolation region and an end of the limb. A perfusion catheter is inserted into a limb artery in an antegrade position, while a collection catheter is inserted into a limb vein in a retrograde position. The blood flow of the limb circulatory system is then circulated by collecting the blood flow with the collection catheter and delivering the blood flow with the perfusion catheter. A medicament is perfused into the limb circulatory system with the perfusion catheter.Type: GrantFiled: November 26, 2014Date of Patent: January 31, 2017Assignee: OSPREY MEDICAL, INC.Inventor: David Martin Kaye
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Publication number: 20160030714Abstract: The present invention provides devices and methods for use in the perfusion of organs and anatomical regions. In one aspect the present method provides a percutaneously deliverable device for supporting a vessel in a human or animal subject including means for supporting the vessel during delivery of a fluid thereto or collection of a fluid therefrom. In another aspect the invention provides a method for delivery or collection of a fluid to or from an organ or anatomical region in a human or animal subject, the method including the step of supporting a vessel associated with the organ or anatomical region. The devices and methods may be used to deliver, remove or recirculate a therapeutic agent to an organ or anatomical region.Type: ApplicationFiled: October 13, 2015Publication date: February 4, 2016Applicant: OSPREY MEDICAL, INC.Inventors: John Melmouth Power, Mark L. Mathis, David Martin Kaye, Adam Lucas Bilney
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Patent number: 9211372Abstract: A method of delivering a medicament to a limb of a patient body includes isolating a circulatory system of the limb from a circulatory system of the patient body, wherein the limb circulatory system is substantially all limb arteries and substantially all limb veins located between an isolation region and an end of the limb. A perfusion catheter is inserted into a limb artery in an antegrade position, while a collection catheter is inserted into a limb vein in a retrograde position. The blood flow of the limb circulatory system is then circulated by collecting the blood flow with the collection catheter and delivering the blood flow with the perfusion catheter. A medicament is perfused into the limb circulatory system with the perfusion catheter.Type: GrantFiled: August 10, 2012Date of Patent: December 15, 2015Assignee: Osprey Medical, Inc.Inventor: David Martin Kaye
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Publication number: 20150202361Abstract: A method includes establishing an initial resistive force on a contrast fluid in a contrast delivery modulation component and injecting the contrast fluid into the patient with an injection syringe fluidly connected to the injection catheter and the contrast fluid inlet port of the contrast delivery modulation component. A contrast delivery measurement component is used to assess a total volume of the contrast fluid injected into the patient and a resistive force imparted upon the contrast fluid in the chamber.Type: ApplicationFiled: March 31, 2015Publication date: July 23, 2015Inventors: Matthew M. Burns, Tuan Doan, Rodney L. Houfburg, David Martin Kaye, Daniel R. Mans, Todd J. Mortier, Dustin Kasel, Dustin L. Kasel
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Publication number: 20150190564Abstract: A method of delivering a medicament to a limb of a patient body includes isolating a circulatory system of the limb from a circulatory system of the patient body, wherein the limb circulatory system is substantially all limb arteries and substantially all limb veins located between an isolation region and an end of the limb. A perfusion catheter is inserted into a limb artery in an antegrade position, while a collection catheter is inserted into a limb vein in a retrograde position. The blood flow of the limb circulatory system is then circulated by collecting the blood flow with the collection catheter and delivering the blood flow with the perfusion catheter. A medicament is perfused into the limb circulatory system with the perfusion catheter.Type: ApplicationFiled: November 26, 2014Publication date: July 9, 2015Inventor: David Martin Kaye
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Publication number: 20150182684Abstract: In a method for substantially isolating cardiac circulation from systemic circulation, flow between the coronary sinus and the right atrium is occluded. A venous collection device having a collection lumen and a support structure is located in the coronary sinus. The support structure is used to maintain patency of the coronary sinus during collection of fluid through the collection lumen. An artificial flow path is provided between the collection lumen and the one or more coronary arteries, thus isolating the cardiac circulation. According to the method, cardiac pumping for systemic circulation can be maintained during isolation of the cardiac circulation.Type: ApplicationFiled: November 12, 2014Publication date: July 2, 2015Applicant: OSPREY MEDICAL, INC.Inventors: David Martin Kaye, Clifton A. Alferness, John Melmouth Power, Adam Lucas Bilney
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Publication number: 20140328908Abstract: The present invention relates to oral controlled-release formulations of 5-(pyridinyl)-2(1H)-pyridinone compounds and their use in the treatment of a subject with heart failure, a stage, class or manifestation of heart failure, or at risk of developing or exhibiting symptoms of heart failure. The formulations of the invention release the compounds in the range of between 0.1 ?g/kg body weight/minute and 20 ?g/kg body weight/minute.Type: ApplicationFiled: August 16, 2012Publication date: November 6, 2014Applicant: Baker IDI Heart & Diabetes Institute Holdings LimitedInventors: David Martin Kaye, Guy Krippner, Geetha Thanga Mariappan
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Publication number: 20130253629Abstract: The present invention provides devices and methods for use in the perfusion of organs and anatomical regions. In one aspect the present method provides a percutaneously deliverable device for supporting a vessel in a human or animal subject including means for supporting the vessel during delivery of a fluid thereto or collection of a fluid therefrom. In another aspect the invention provides a method for delivery or collection of a fluid to or from an organ or anatomical region in a human or animal subject, the method including the step of supporting a vessel associated with the organ or anatomical region. The devices and methods may be used to deliver, remove or recirculate a therapeutic agent to an organ or anatomical region.Type: ApplicationFiled: May 13, 2013Publication date: September 26, 2013Applicant: Osprey Medical Inc.Inventors: John Melmouth Power, Mark L. Mathis, David Martin Kaye, Adam Lucas Bilney