Abstract: The disclosure provides a method for treating a subject afflicted with a cancer comprising administering to the subject a therapeutically effective amount of an anti-PD-1 antagonist, e.g., an anti-PD-1 or anti-PD-L1 antibody, in combination with an indoleamine 2,3-dioxygenase inhibitor, wherein the subject is identified as exhibiting a combined biomarker comprising (a) a high IFN? inflammatory signature score and (b) a low tryptophan 2,3-dioxygenase 2 (TDO2) gene expression score. The high IFN? inflammatory signature score is determined by measuring the expression of a panel of IFN? related inflammatory genes in a cancer sample obtained from the subject, wherein the gene panel comprises, e.g., IFN?, CXCL10, CXCL9, HLA-DRA, IDO1, and STAT1. In some aspects, the gene panel further comprises CCR5, CXCL11, GZMA, and PRF1. In some aspects, the gene panel comprises CXCR6, TIGIT, PD-L1, PD-L2, LAG3, NKG7, PSMB10, CMKLR1, CD8A, IDO1, CCL5, CXCL9, HLA.DQA1, CD276, HLA.DRB1, STAT1, HLA.E, and TDO2.

Abstract: An Internet delivery method delivers electronic information products to a plurality of users via the Internet. A plurality of display formats are stored in a database. The display formats including at least a default display format and a custom display format. Information is also stored for each user indicating whether the user is a specific type of user. When a user logs in, the user is identified as being that specific type of user. If the user is identified as the specific type of user, then an electronic information product is delivered to the user in the custom display format. The electronic information products are accessed via computers connected to the Internet, including wireless devices.

Abstract: An Internet delivery method delivers electronic information products to a plurality of users via the Internet. A plurality of display formats are stored in a database. The display formats including at least a default display format and a custom display format. Information is also stored for each user indicating whether the user is a specific type of user. When a user logs in, the user is identified as being that specific type of user. If the user is identified as the specific type of user, then an electronic information product is delivered to the user in the custom display format. The electronic information products are accessed via computers connected to the Internet, including wireless devices.

Abstract: An Internet delivery method delivers electronic information products to a plurality of users via the Internet. A plurality of display formats are stored in a database. The display formats including at least a default display format and a custom display format. Information is also stored for each user indicating whether the user is a specific type of user. When a user logs in, the user is identified as being that specific type of user. If the user is identified as the specific type of user, then an electronic information product is delivered to the user in the custom display format. The electronic information products are accessed via computers connected to the Internet, including wireless devices.