Patents by Inventor David Matzinger
David Matzinger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9709521Abstract: Methods and systems to apply a plurality of test voltages to the test strip and measure a current transient output resulting from an electrochemical reaction in a test chamber of the test strip so that a glucose concentration can be determined that account for interferent substances in the body fluid sample. A method of determining blood glucose concentration with a glucose measurement system that includes a test strip and test meter. The test meter has a microcontroller configured to apply a plurality of test voltages to the test strip and measure a current transient output resulting from an electrochemical reaction in a test chamber of the test strip.Type: GrantFiled: March 20, 2012Date of Patent: July 18, 2017Assignee: Cilag GmbH InternationalInventors: David Matzinger, Maria Teodorczyk
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Publication number: 20140311924Abstract: Methods and systems to apply a plurality of test voltages to the test strip and measure a current transient output resulting from an electrochemical reaction in a test chamber of the test strip so that a glucose concentration can be determined that account for interferent substances in the body fluid sample. A method of determining blood glucose concentration with a glucose measurement system that includes a test strip and test meter. The test meter has a microcontroller configured to apply a plurality of test voltages to the test strip and measure a current transient output resulting from an electrochemical reaction in a test chamber of the test strip.Type: ApplicationFiled: March 20, 2012Publication date: October 23, 2014Applicant: Cilag GmbH InternationalInventors: David Matzinger, Maria Teodorczyk
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Patent number: 8709232Abstract: Described are methods and systems to apply a plurality of test voltages to the test strip and measure a current transient output resulting from an electrochemical reaction in a test chamber of the test strip so that highly accurate glucose concentration can be determined.Type: GrantFiled: April 30, 2012Date of Patent: April 29, 2014Assignee: Cilag GmbH InternationalInventor: David Matzinger
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Patent number: 8580576Abstract: A method for the transfer of a bodily fluid sample (such as a whole blood sample) during the determination of an analyte (e.g., glucose) in the bodily fluid sample includes applying the bodily fluid sample to a sample collection reservoir of an analytical test strip (for example, an electrochemical-based analytical test strip). During such application, the sample collection reservoir is isolated from fluid communication with a determination chamber of the analytical test strip. The analytical test strip is subsequently inserted into a test meter such that the sample collection reservoir is placed into fluid communication with the determination chamber and such that at least a portion of the bodily fluid sample is consequentially transferred from the sample collection reservoir to the determination chamber. The method further includes determining the analyte in the bodily fluid sample transferred to the determination chamber.Type: GrantFiled: August 4, 2011Date of Patent: November 12, 2013Assignee: Cilag GmbH InternationalInventors: Khalid R. Quraishi, David Matzinger
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Publication number: 20130284611Abstract: Described are methods and systems to apply a plurality of test voltages to the test strip and measure a current transient output resulting from an electrochemical reaction in a test chamber of the test strip so that highly accurate glucose concentration can be determined.Type: ApplicationFiled: April 30, 2012Publication date: October 31, 2013Applicant: Cilag GmbH InternationalInventor: David MATZINGER
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Patent number: 8475733Abstract: A hand-held test meter and analytical test strip cartridge assembly combination includes a hand-held test meter with a test meter housing and an extractor with a test strip engagement feature, while the analytical test strip cartridge assembly includes a desiccant vial and an analytical test strip cartridge with a cartridge housing, a test strip presentation mechanism disposed within the cartridge housing, and a plurality of analytical test strips (each with at least one extractor engagement feature) disposed in the cartridge housing. The test meter housing is configured for operative engagement with the cartridge housing and the test strip presentation mechanism is configured to present a single analytical test strip from the plurality of analytical test strips for engagement with the extractor. Moreover, the analytical test strip cartridge is configured for operative disposition in the desiccant vial.Type: GrantFiled: May 4, 2012Date of Patent: July 2, 2013Assignee: Cilag GmbH InternationalInventor: David Matzinger
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Publication number: 20130034872Abstract: A hand-held test meter and analytical test strip cartridge assembly combination includes a hand-held test meter with a test meter housing and an extractor with a test strip engagement feature, while the analytical test strip cartridge assembly includes a desiccant vial and an analytical test strip cartridge with a cartridge housing, a test strip presentation mechanism disposed within the cartridge housing, and a plurality of analytical test strips (each with at least one extractor engagement feature) disposed in the cartridge housing. The test meter housing is configured for operative engagement with the cartridge housing and the test strip presentation mechanism is configured to present a single analytical test strip from the plurality of analytical test strips for engagement with the extractor. Moreover, the analytical test strip cartridge is configured for operative disposition in the desiccant vial.Type: ApplicationFiled: May 4, 2012Publication date: February 7, 2013Applicant: Cilag GmbH InternationalInventor: David MATZINGER
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Publication number: 20130034870Abstract: A method for the transfer of a bodily fluid sample (such as a whole blood sample) during the determination of an analyte (e.g., glucose) in the bodily fluid sample includes applying the bodily fluid sample to a sample collection reservoir of an analytical test strip (for example, an electrochemical-based analytical test strip). During such application, the sample collection reservoir is isolated from fluid communication with a determination chamber of the analytical test strip. The analytical test strip is subsequently inserted into a test meter such that the sample collection reservoir is placed into fluid communication with the determination chamber and such that at least a portion of the bodily fluid sample is consequentially transferred from the sample collection reservoir to the determination chamber. The method further includes determining the analyte in the bodily fluid sample transferred to the determination chamber.Type: ApplicationFiled: August 4, 2011Publication date: February 7, 2013Inventors: Khalid R. QURAISHI, David Matzinger
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Publication number: 20130034871Abstract: A hand-held test meter and analytical test strip cartridge combination includes a hand-held test meter with a test meter housing and an extractor with a test strip engagement feature, while the analytical test strip cartridge includes a cartridge housing, a test strip presentation mechanism disposed within the cartridge housing, and a plurality of analytical test strips (each with at least one extractor engagement feature) disposed in the cartridge housing. Moreover, the test meter housing is configured for operative engagement with the cartridge housing, the test strip presentation mechanism is configured to present a single analytical test strip from the plurality of analytical test strips for engagement with the extractor, and the extractor and test meter housing are configured such that the extractor is operatively extendable from the test meter housing into the cartridge housing upon engagement of the meter housing with the cartridge housing.Type: ApplicationFiled: August 4, 2011Publication date: February 7, 2013Applicant: Cilag GmbH InternationalInventors: David MATZINGER, Khalid R. Quraishi
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Publication number: 20070207498Abstract: Embodiments of the invention provide for compositions comprising purified polypeptides such as purified Concanavalin A (ConA) mutants. In addition, embodiments provide for polypeptides and nucleic acids encoding those polypeptides, such as mutant ConA with reduced dimer-dimer interactions compared to wild type ConA. Some embodiments also provide for sensors comprising the polypeptides disclosed herein. The embodiments also provide an improved method of producing recombinant mutant ConA.Type: ApplicationFiled: August 30, 2006Publication date: September 6, 2007Applicant: LifeScan, Inc.Inventors: Stephen Palmieri, Dylan Bulseco, David Matzinger
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Patent number: 7118916Abstract: Methods, devices and kits for facilitating medical diagnostic assays and reducing the time required for taking of such assays. The methods comprise initiating a reaction, obtaining at least three measurements, at three different time points, of a value or level of an observable associated with the reaction, and estimating an end point value for the observable from the measurements.Type: GrantFiled: October 21, 2002Date of Patent: October 10, 2006Assignee: Lifescan, Inc.Inventor: David Matzinger
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Patent number: 7070564Abstract: Methods and devices are provided for determining a suitable site for sampling physiological fluid. In the subject methods, a potentially suitable physiological sampling site is selected, the fluid flow of the site is characterized and the site is then determined to be suitable based on the whether the site has high or low flow. Suitability may also be determined based on the type of sample obtainable from the site, where the order of the above-described steps may be altered. The subject devices include at least one site flow characterization element for determining the flow characteristics of a potential physiological sampling site and/or at least one sample type characterization element for determining whether the vasculature is arterial, venous or neither, i.e., an interstitial fluid sampling site. The subject methods and devices are particularly suited for use in the detection of physiological sampling sites in the fingers, arms, legs, earlobes, heels, feet, nose and toes.Type: GrantFiled: November 22, 2004Date of Patent: July 4, 2006Assignee: LifeScan, Inc.Inventors: David Matzinger, Khalid R. Quraishi
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Publication number: 20060024835Abstract: An analytical test strip for the determination of an analyte (e.g., glucose) in a liquid sample (such as whole blood) includes a matrix, with the matrix having a sample detection zone and a control zone(s). The sample detection zone includes a first reagent composition that reacts with analyte in the liquid sample to create a sample response and is configured to receive a first portion of the liquid sample. The control zone(s) includes a second reagent composition and is configured to receive another portion(s) of the liquid sample. In addition, the second reagent composition creates a predetermined control response when exposed to the second portion of the liquid sample. The predetermined control response, either alone or in combination with the sample response, can be employed to verify acceptable functioning of the analytical test strip and/or to provide a calibration factor for the analytical test strip.Type: ApplicationFiled: July 30, 2004Publication date: February 2, 2006Inventors: David Matzinger, Sherry Guo, Khalid Quraishi
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Patent number: 6939310Abstract: Methods and devices are provided for determining a suitable site for sampling physiological fluid. In the subject methods, a potentially suitable physiological sampling site is selected, the fluid flow of the site is characterized and the site is then determined to be suitable based on the whether the site has high or low flow. Suitability may also be determined based on the type of sample obtainable from the site, where the order of the above-described steps may be altered. The subject devices include at least one site flow characterization element for determining the flow characteristics of a potential physiological sampling site and/or at least one sample type characterization element for determining whether the vasculature is arterial, venous or neither, i.e., an interstitial fluid sampling site. The subject methods and devices are particularly suited for use in the detection of physiological sampling sites in the fingers, arms, legs, earlobes, heels, feet, nose and toes.Type: GrantFiled: October 10, 2001Date of Patent: September 6, 2005Assignee: LifeScan, Inc.Inventors: David Matzinger, Khalid R. Quraishi
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Publication number: 20050113717Abstract: Methods and devices are provided for determining a suitable site for sampling physiological fluid. In the subject methods, a potentially suitable physiological sampling site is selected, the fluid flow of the site is characterized and the site is then determined to be suitable based on the whether the site has high or low flow. Suitability may also be determined based on the type of sample obtainable from the site, where the order of the above-described steps may be altered. The subject devices include at least one site flow characterization element for determining the flow characteristics of a potential physiological sampling site and/or at least one sample type characterization element for determining whether the vasculature is arterial, venous or neither, i.e., an interstitial fluid sampling site. The subject methods and devices are particularly suited for use in the detection of physiological sampling sites in the fingers, arms, legs, earlobes, heels, feet, nose and toes.Type: ApplicationFiled: November 22, 2004Publication date: May 26, 2005Inventors: David Matzinger, Khalid Quraishi
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Patent number: 6884592Abstract: Test strips for determining the concentration of at least one analyte, e.g., glucose, in a physiological sample and methods for their manufacture and use and are provided. The subject test strips include a transfer element for facilitating the transfer of sample to a reaction area of the test strip. In certain embodiments, the transfer element, typically porous, has a first area and a second area, and in certain embodiments the two areas have different thicknesses. In other embodiments, the transfer element is non-porous and is configured to transfer sample by wicking it between the transfer element and the reaction area of the test strip. In the subject methods, the transport element facilitates transfers of a sample to a reaction area of the test strip. The subject test strips and methods find use in a variety of different applications, particularly in the determination of glucose concentrations.Type: GrantFiled: September 5, 2001Date of Patent: April 26, 2005Assignee: LifeScan, Inc.Inventors: David Matzinger, Khalid R. Quraishi, Yeung Siu Yu
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Publication number: 20050042135Abstract: Test strips for determining the concentration of at least one analyte, e.g., glucose, in a physiological sample and methods for their manufacture and use and are provided. The subject test strips include a transfer element for facilitating the transfer of sample to a reaction area of the test strip. In certain embodiments, the transfer element, typically porous, has a first area and a second area, and in certain embodiments the two areas have different thicknesses. In other embodiments, the transfer element is non-porous and is configured to transfer sample by wicking it between the transfer element and the reaction area of the test strip. In the subject methods, the transport element facilitates transfers of a sample to a reaction area of the test strip. The subject test strips and methods find use in a variety of different applications, particularly in the determination of glucose concentrations.Type: ApplicationFiled: September 10, 2004Publication date: February 24, 2005Inventors: David Matzinger, Khalid Quraishi, Yeung Yu
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Publication number: 20040078149Abstract: Methods, devices and kits for facilitating medical diagnostic assays and reducing the time required for taking of such assays. The methods comprise initiating a reaction, obtaining at least three measurements, at three different time points, of a value or level of an observable associated with the reaction, and estimating an end point value for the observable from the measurements.Type: ApplicationFiled: October 21, 2002Publication date: April 22, 2004Inventor: David Matzinger
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Publication number: 20030069509Abstract: Methods and devices are provided for determining a suitable site for sampling physiological fluid. In the subject methods, a potentially suitable physiological sampling site is selected, the fluid flow of the site is characterized and the site is then determined to be suitable based on the whether the site has high or low flow. Suitability may also be determined based on the type of sample obtainable from the site, where the order of the above-described steps may be altered. The subject devices include at least one site flow characterization element for determining the flow characteristics of a potential physiological sampling site and/or at least one sample type characterization element for determining whether the vasculature is arterial, venous or neither, i.e., an interstitial fluid sampling site. The subject methods and devices are particularly suited for use in the detection of physiological sampling sites in the fingers, arms, legs, earlobes, heels, feet, nose and toes.Type: ApplicationFiled: October 10, 2001Publication date: April 10, 2003Inventors: David Matzinger, Khalid R. Quraishi
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Publication number: 20030044854Abstract: Test strips for determining the concentration of at least one analyte, e.g., glucose, in a physiological sample and methods for their manufacture and use and are provided. The subject test strips include a transfer element for facilitating the transfer of sample to a reaction area of the test strip. In certain embodiments, the transfer element, typically porous, has a first area and a second area, and in certain embodiments the two areas have different thicknesses. In other embodiments, the transfer element is non-porous and is configured to transfer sample by wicking it between the transfer element and the reaction area of the test strip. In the subject methods, the transport element facilitates transfers of a sample to a reaction area of the test strip. The subject test strips and methods find use in a variety of different applications, particularly in the determination of glucose concentrations.Type: ApplicationFiled: September 5, 2001Publication date: March 6, 2003Inventors: David Matzinger, Khalid R. Quraishi