Abstract: Methods and compositions are provided for oligonucleotides that bind targets of interest. The targets include cells and microvesicles, such as those derived from various diseases. The oligonucleotides can be used for diagnostic and therapeutic purposes. The target of the oligonucleotides can be a target such as PARP1, HIST1H1B, HIST1H1D, NCL, FBL, SFPQ, RPL12, ACTB, HIST1H4A, SSBP1, NONO, H2AFJ, and DDX21, or a complex, subunit or fragment thereof.

Abstract: A method to reinforce a built structure, wherein an impregnation resin including a resin component including at least one epoxy resin and hardener component including at least one amine of the formula (I) is used to impregnate woven or stitched fabric, which is wrapped around and/or adhered onto built structure. The inventive method preferably serves to improve earthquake safety of buildings, as replacement for missing reinforcement inside concrete, for improvement of strength and ductility or for increase of payload of a built structure. It enables the application of an emission-free impregnation resin with low odour, which has a long open time and good penetration into the fabric, shows fast and reliable curing without tendency to blushing, and forms a dry, non-sticky surface. The cured impregnation resin has a high strength, a high glass transition temperature and good adhesion properties, enabling a good durability and long-term stability of the reinforced structure.

Abstract: A network device includes a receive processor configured to store, in a packet memory, a payload of a packet received from a communication network. The network device also includes a packet processor configured to modify one or more fields of a header of the packet to generate a modified header, perform egress classification of the packet based on the modified header, and store the modified header in the packet memory. The network device further includes a transmit processor configured to transmit the packet in accordance with the egress classification. The transmit processor is configured to, in response to a decision that the packet is to be transmitted from the network device, generate a transmit packet from the payload retrieved from the packet memory and the modified header retrieved from the packet memory and cause the transmit packet to be transmitted to a destination in the communication network.

Abstract: A computer-implemented method for conducting pairing processes to identify transport sources. Rules for the pairing processes are generated based on a transport request received from a client interface. The rules determine parameters such as when the process is initiated, or how many iterations it has. Transport sources are then pre-selected in a certain area and sources not fulfilling necessary criteria, e.g., unable to transport the subject of the transport described in the transport request or busy with another transport, are excluded. The remaining sources receive pairing values which can be accepted by the sources. From the accepting sources, one can be confirmed from the client interface.

Abstract: Systems and methods of delivering a therapeutic session to affect a mental or an emotional state of a user include providing a wearable stimulation device having a transducer adapted to generate tactile transcutaneous vibratory output; with a user interface, obtaining data regarding an event to be experienced by the user; communicating the data regarding an event to be experienced by the user to a computer processor; with the computer processor, creating a therapeutic session parameters comprising the following steps: assigning a set of contiguous output segments for the event, and based on the event, assigning a perceived pitch of transcutaneous vibratory output and a perceived beat of transcutaneous vibratory output to each output segment; sending, from the computer processor, the therapeutic session parameters to the transducer; and generating, with the transducer, transcutaneous vibratory output for the therapeutic session based on the therapeutic session parameters.

Abstract: A peripheral device for regulating neural correlates of arousal and emotion regulation to be worn or held against the body is disclosed. The device can be triggered by either physiological signs or manual intervention and produces cutaneous signals such as vibration or electricity using novel combinations of physiologically reactive frequencies without effort on the part of the user. One embodiment includes combining sensors that measure changes in physiological signals of stress such as speech rate and pitch, galvanic skin response, or heart rate variability, and, using a machine learning algorithm on personalized data, can determine whether these changes are likely to benefit from regulation. If they are outside an idiosyncratic predetermined range, the device produces stimulation and the person will feel regulated if they are touching/wearing the device, or can choose to use the device if it is not currently being touched or worn.

Abstract: A method and system of sleep maintenance includes configuring a stimulation device comprising a transducer to emit a transcutaneous vibratory output to a body part of a subject, receiving physiological data of the subject from at least one sensor at a processor, providing a stimulation pattern for the transcutaneous vibratory output to be emitted by the transducer, the stimulation pattern comprising a perceived pitch, a perceived beat, and an intensity of the transcutaneous vibratory output, causing the transducer to emit the transcutaneous vibratory output in the stimulation pattern, determining a sleep state of the subject based on the physiological data, and altering the stimulation pattern based on the sleep state, wherein altering comprises at least one of (i) reducing a frequency of the perceived pitch, (ii) increasing an interval of the perceived beat, or (iii) reducing the intensity.

Abstract: Systems and methods of treating a sleep disorder of a subject include providing a therapeutic stimulation device comprising a transducer configured to emit transcutaneous vibratory output to a body part of the subject; generating physiological data with a worn sensor and providing it to a processor; providing a stimulation pattern for transcutaneous vibratory output to be emitted by the transducer comprising a perceived pitch, a perceived beat, and an intensity; causing the transducer to emit the transcutaneous vibratory output in the stimulation pattern; determining if the subject is in a pre-sleep state or a sleep state based on the physiological data; and altering the stimulation pattern based on determining the subject is in at least one of a pre-sleep state or a sleep state comprising at least one of (i) reducing a frequency of the perceived pitch, (ii) increasing an interval of the perceived beat, or (iii) reducing the intensity.

Abstract: Systems and methods of assisting a subject to reach a target state of sexual arousal include obtaining input of the target state of the subject; and generating a transcutaneous vibratory output to be applied to a portion of a body of the subject to assist the subject in achieving the target state of sexual arousal, the transcutaneous vibratory output having variable parameters comprising a perceived pitch, a perceived beat, and a perceived intensity wherein the step of generating the transcutaneous vibratory output further comprises the step of modifying the variable parameters to correspond to the target state.

Abstract: Systems and methods disclosed herein relate to augmenting a treatment modality. A method of providing stimulation therapy to a user may include generating transcutaneous vibratory output comprising one or more variable parameters, subjecting the user, in conjunction with the transcutaneous vibratory output, to a treatment modality, wherein the one or more variable parameters of the transcutaneous vibratory output comprise at least one of a perceived pitch, a perceived beat, a perceived intensity, an envelope, or a base tone, and at least one of selecting or modifying the one or more variable parameters of the transcutaneous vibratory output to augment the treatment modality.

Abstract: Systems and methods disclosed herein relate to causing an epigenetic change in a user. The methods include measuring an epigenetic marker in the user, wherein the epigenetic marker is at least one of a regulation of a protein or a gene; or a methylation, acetylation, or phosphorylation status of at least one of a gene, histone, or portion of DNA. The methods further include subjecting a user to a first transcutaneous vibratory output selected to assist the user in achieving a target state, the first transcutaneous vibratory output comprising a first perceived pitch, a first perceived beat, and a perceived intensity, and repeating the measurement of the epigenetic marker to identify a change in an aspect of the epigenetic marker as a result of subjecting the user to the first transcutaneous vibratory output.

Abstract: Delivering vibratory therapy to a user may include using a system with a first transducer adapted to emit a first transcutaneous vibratory output; a second transducer adapted to emit a second transcutaneous vibratory output; and a processor in electronic communication with a user interface, the first transducer, and the second transducer, wherein the user interface accepts a user target state. The processor may be programmed to (i) generate a first transcutaneous vibratory output pattern comprising a first perceived pitch, a first perceived beat, and a first intensity; (ii) generate a second transcutaneous vibratory output pattern comprising a second perceived pitch, a second perceived beat, and a second intensity; (iii) cause the first transducer to emit a first transcutaneous vibratory output based on the first transcutaneous vibratory output pattern; and (iv) cause the second transducer to emit a second transcutaneous vibratory output based on the second transcutaneous vibratory output pattern.

Abstract: In one embodiment, a method includes determining a job match between a candidate and a job posted by a hiring entity, providing the job match for presentation on a computing device of a referrer, receiving, from the computing device of the referrer, a selection to share the job match with the candidate, transmitting, to the candidate, a message comprising the job match and information pertaining to the referrer, receiving, from the candidate, an acceptance for the referrer to recommend the candidate to the hiring entity for the job, transmitting, to the computing device of the hiring entity, a recommendation for the candidate on behalf of the referrer, receiving, from the hiring entity, a selection of the candidate to apply for the job, wherein the selection is based on the recommendation, and transmitting, to the computing device of the candidate, an invitation to interview for the job.

Abstract: Systems and methods of assisting a subject to reach a target state include obtaining input of the target state of the subject; and generating a transcutaneous vibratory output to be applied to a portion of a body of the subject to assist the subject in achieving the target state, the transcutaneous vibratory output having variable parameters comprising a perceived pitch, a perceived beat, and a perceived intensity wherein the step of generating the transcutaneous vibratory output further comprises the step of modifying the variable parameters to correspond to the target state.

Abstract: Certain pet products, such as collar, halters, pet beds, and the like, may be adapted to provide transcutaneous vibratory output. A device adapted to be worn by a non-human animal may include i) at least one of a collar or a harness structured to fit the non-human animal; and ii) at least one transducer located at least partially within the at least one collar or harness and structured to deliver a transcutaneous vibratory output to the non-human animal, the transcutaneous vibratory output having variable parameters comprising a perceived pitch, a perceived beat, and a perceived intensity.

Abstract: Systems and methods to mitigate negative effects of a drug in a treatment of a mental health condition include administering a drug to a subject in a therapy session; determining effects of the drug, the effects being counterproductive to the therapy session; and providing tactile stimulation to a subject with a stimulation device that generates transcutaneous vibratory output to be applied to a portion of a body of the subject during the therapy session, wherein the transcutaneous vibratory output is selected to reduce the counterproductive effects of the drug.

Abstract: Systems and methods to mitigate negative effects of a drug in a treatment of a mental health condition include administering a drug to a subject in a therapy session; determining effects of the drug, the effects being counterproductive to the therapy session; and providing tactile stimulation to a subject with a stimulation device that generates transcutaneous vibratory output to be applied to a portion of a body of the subject during the therapy session, wherein the transcutaneous vibratory output is selected to reduce the counterproductive effects of the drug.