Abstract: Systems and methods of delivering a therapeutic session to affect a mental or an emotional state of a user include providing a wearable stimulation device having a transducer adapted to generate tactile transcutaneous vibratory output; with a user interface, obtaining data regarding an event to be experienced by the user; communicating the data regarding an event to be experienced by the user to a computer processor; with the computer processor, creating a therapeutic session parameters comprising the following steps: assigning a set of contiguous output segments for the event, and based on the event, assigning a perceived pitch of transcutaneous vibratory output and a perceived beat of transcutaneous vibratory output to each output segment; sending, from the computer processor, the therapeutic session parameters to the transducer; and generating, with the transducer, transcutaneous vibratory output for the therapeutic session based on the therapeutic session parameters.

Abstract: A peripheral device for regulating neural correlates of arousal and emotion regulation to be worn or held against the body is disclosed. The device can be triggered by either physiological signs or manual intervention and produces cutaneous signals such as vibration or electricity using novel combinations of physiologically reactive frequencies without effort on the part of the user. One embodiment includes combining sensors that measure changes in physiological signals of stress such as speech rate and pitch, galvanic skin response, or heart rate variability, and, using a machine learning algorithm on personalized data, can determine whether these changes are likely to benefit from regulation. If they are outside an idiosyncratic predetermined range, the device produces stimulation and the person will feel regulated if they are touching/wearing the device, or can choose to use the device if it is not currently being touched or worn.

Abstract: A method and system of sleep maintenance includes configuring a stimulation device comprising a transducer to emit a transcutaneous vibratory output to a body part of a subject, receiving physiological data of the subject from at least one sensor at a processor, providing a stimulation pattern for the transcutaneous vibratory output to be emitted by the transducer, the stimulation pattern comprising a perceived pitch, a perceived beat, and an intensity of the transcutaneous vibratory output, causing the transducer to emit the transcutaneous vibratory output in the stimulation pattern, determining a sleep state of the subject based on the physiological data, and altering the stimulation pattern based on the sleep state, wherein altering comprises at least one of (i) reducing a frequency of the perceived pitch, (ii) increasing an interval of the perceived beat, or (iii) reducing the intensity.

Abstract: Systems and methods of treating a sleep disorder of a subject include providing a therapeutic stimulation device comprising a transducer configured to emit transcutaneous vibratory output to a body part of the subject; generating physiological data with a worn sensor and providing it to a processor; providing a stimulation pattern for transcutaneous vibratory output to be emitted by the transducer comprising a perceived pitch, a perceived beat, and an intensity; causing the transducer to emit the transcutaneous vibratory output in the stimulation pattern; determining if the subject is in a pre-sleep state or a sleep state based on the physiological data; and altering the stimulation pattern based on determining the subject is in at least one of a pre-sleep state or a sleep state comprising at least one of (i) reducing a frequency of the perceived pitch, (ii) increasing an interval of the perceived beat, or (iii) reducing the intensity.

Abstract: Systems and methods of assisting a subject to reach a target state of sexual arousal include obtaining input of the target state of the subject; and generating a transcutaneous vibratory output to be applied to a portion of a body of the subject to assist the subject in achieving the target state of sexual arousal, the transcutaneous vibratory output having variable parameters comprising a perceived pitch, a perceived beat, and a perceived intensity wherein the step of generating the transcutaneous vibratory output further comprises the step of modifying the variable parameters to correspond to the target state.

Abstract: Systems and methods disclosed herein relate to augmenting a treatment modality. A method of providing stimulation therapy to a user may include generating transcutaneous vibratory output comprising one or more variable parameters, subjecting the user, in conjunction with the transcutaneous vibratory output, to a treatment modality, wherein the one or more variable parameters of the transcutaneous vibratory output comprise at least one of a perceived pitch, a perceived beat, a perceived intensity, an envelope, or a base tone, and at least one of selecting or modifying the one or more variable parameters of the transcutaneous vibratory output to augment the treatment modality.

Abstract: Systems and methods disclosed herein relate to causing an epigenetic change in a user. The methods include measuring an epigenetic marker in the user, wherein the epigenetic marker is at least one of a regulation of a protein or a gene; or a methylation, acetylation, or phosphorylation status of at least one of a gene, histone, or portion of DNA. The methods further include subjecting a user to a first transcutaneous vibratory output selected to assist the user in achieving a target state, the first transcutaneous vibratory output comprising a first perceived pitch, a first perceived beat, and a perceived intensity, and repeating the measurement of the epigenetic marker to identify a change in an aspect of the epigenetic marker as a result of subjecting the user to the first transcutaneous vibratory output.

Abstract: Delivering vibratory therapy to a user may include using a system with a first transducer adapted to emit a first transcutaneous vibratory output; a second transducer adapted to emit a second transcutaneous vibratory output; and a processor in electronic communication with a user interface, the first transducer, and the second transducer, wherein the user interface accepts a user target state. The processor may be programmed to (i) generate a first transcutaneous vibratory output pattern comprising a first perceived pitch, a first perceived beat, and a first intensity; (ii) generate a second transcutaneous vibratory output pattern comprising a second perceived pitch, a second perceived beat, and a second intensity; (iii) cause the first transducer to emit a first transcutaneous vibratory output based on the first transcutaneous vibratory output pattern; and (iv) cause the second transducer to emit a second transcutaneous vibratory output based on the second transcutaneous vibratory output pattern.

Abstract: Systems and methods of assisting a subject to reach a target state include obtaining input of the target state of the subject; and generating a transcutaneous vibratory output to be applied to a portion of a body of the subject to assist the subject in achieving the target state, the transcutaneous vibratory output having variable parameters comprising a perceived pitch, a perceived beat, and a perceived intensity wherein the step of generating the transcutaneous vibratory output further comprises the step of modifying the variable parameters to correspond to the target state.

Abstract: Certain pet products, such as collar, halters, pet beds, and the like, may be adapted to provide transcutaneous vibratory output. A device adapted to be worn by a non-human animal may include i) at least one of a collar or a harness structured to fit the non-human animal; and ii) at least one transducer located at least partially within the at least one collar or harness and structured to deliver a transcutaneous vibratory output to the non-human animal, the transcutaneous vibratory output having variable parameters comprising a perceived pitch, a perceived beat, and a perceived intensity.

Abstract: Systems and methods to mitigate negative effects of a drug in a treatment of a mental health condition include administering a drug to a subject in a therapy session; determining effects of the drug, the effects being counterproductive to the therapy session; and providing tactile stimulation to a subject with a stimulation device that generates transcutaneous vibratory output to be applied to a portion of a body of the subject during the therapy session, wherein the transcutaneous vibratory output is selected to reduce the counterproductive effects of the drug.

Abstract: Systems and methods of treating a sleep disorder of a subject include providing a therapeutic stimulation device comprising a transducer configured to emit transcutaneous vibratory output to a body part of the subject; generating physiological data with a worn sensor and providing it to a processor; providing a stimulation pattern for transcutaneous vibratory output to be emitted by the transducer comprising a perceived pitch, a perceived beat, and an intensity; causing the transducer to emit the transcutaneous vibratory output in the stimulation pattern; determining if the subject is in a pre-sleep state or a sleep state based on the physiological data; and altering the stimulation pattern based on determining the subject is in at least one of a pre-sleep state or a sleep state comprising at least one of (i) reducing a frequency of the perceived pitch, (ii) increasing an interval of the perceived beat, or (iii) reducing the intensity.

Abstract: Systems and methods to mitigate negative effects of a drug in a treatment of a mental health condition include administering a drug to a subject in a therapy session; determining effects of the drug, the effects being counterproductive to the therapy session; and providing tactile stimulation to a subject with a stimulation device that generates transcutaneous vibratory output to be applied to a portion of a body of the subject during the therapy session, wherein the transcutaneous vibratory output is selected to reduce the counterproductive effects of the drug.

Abstract: Systems and methods of assisting a subject to reach a target state include obtaining input of the target state of the subject; and generating a transcutaneous vibratory output to be applied to a portion of a body of the subject to assist the subject in achieving the target state, the transcutaneous vibratory output having variable parameters comprising a perceived pitch, a perceived beat, and a perceived intensity wherein the step of generating the transcutaneous vibratory output further comprises the step of modifying the variable parameters to correspond to the target state.

Abstract: Systems and methods of delivering a therapeutic session to affect a mental or an emotional state of a user include providing a wearable stimulation device having a transducer adapted to generate tactile transcutaneous vibratory output; with a user interface, obtaining data regarding an event to be experienced by the user; communicating the data regarding an event to be experienced by the user to a computer processor; with the computer processor, creating a therapeutic session parameters comprising the following steps: assigning a set of contiguous output segments for the event, and based on the event, assigning a perceived pitch of transcutaneous vibratory output and a perceived beat of transcutaneous vibratory output to each output segment; sending, from the computer processor, the therapeutic session parameters to the transducer; and generating, with the transducer, transcutaneous vibratory output for the therapeutic session based on the therapeutic session parameters.

Abstract: An improved method of treating depression in a person can be generally said to include applying to a body area of the person a therapeutic stimulation device having a tactile transducer that is positioned proximate the body area, and emitting with the tactile transducer a vibrational output toward the body area. A therapeutic stimulation device and a non-transitory machine-readable storage medium are also disclosed.

Abstract: A peripheral device for regulating neural correlates of arousal and emotion regulation to be worn or held against the body is disclosed. The device can be triggered by either physiological signs or manual intervention and produces cutaneous signals such as vibration or electricity using novel combinations of physiologically reactive frequencies without effort on the part of the user. One embodiment includes combining sensors that measure changes in physiological signals of stress such as speech rate and pitch, galvanic skin response, or heart rate variability, and, using a machine learning algorithm on personalized data, can determine whether these changes are likely to benefit from regulation. If they are outside an idiosyncratic predetermined range, the device produces stimulation and the person will feel regulated if they are touching/wearing the device, or can choose to use the device if it is not currently being touched or worn.