Patents by Inventor David McComsey

David McComsey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Indazolyl-substituted pyrroline compounds as kinase inhibitors
    Publication number: 20080096949
    Abstract: The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Application
    Filed: December 13, 2007
    Publication date: April 24, 2008
    Inventors: Han-Cheng Zhang, Bruce Maryanoff, Bruce Conway, Kimberly White, Hong Ye, Leonard Hecker, David McComsey
  • CO-THERAPY FOR THE TREATMENT OF EPILEPSY AND RELATED DISORDERS
    Publication number: 20070293440
    Abstract: The present invention is directed to co-therapy for the treatment of epilepsy and related disorders comprising administering to a subject in need thereof, co-therapy with a therapeutically effective amount of a benzo-fused heterocycle sulfamide derivative and a therapeutically effective amount of one or more anticonvulsant and/or anti-epileptic agents.
    Type: Application
    Filed: May 18, 2007
    Publication date: December 20, 2007
    Inventors: Virginia Smith-Swintosky, David McComsey, Michael Parker, Allen Reitz, Bruce Maryanoff
  • Substituted pyrrolines as kinase inhibitors
    Publication number: 20070213386
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Application
    Filed: May 8, 2007
    Publication date: September 13, 2007
    Inventors: Han-Cheng Zhang, Bruce Maryanoff, David McComsey, Kimberly White, Hong Ye, Leonard Hecker, Bruce Conway, Keith Demarest
  • Substituted pyrrolines as kinase inhibitors
    Publication number: 20070213387
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Application
    Filed: May 8, 2007
    Publication date: September 13, 2007
    Inventors: Han-Cheng Zhang, Bruce Maryanoff, David McComsey, Kimberly White, Hong Ye, Leonard Hecker, Bruce Conway, Keith Demarest
  • Substituted pyrroline kinase inhibitors
    Publication number: 20060205762
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
    Type: Application
    Filed: May 17, 2006
    Publication date: September 14, 2006
    Inventors: Han-Cheng Zhang, Gee-Hong Kuo, Bruce Maryanoff, Hong Ye, David O'Neill, Lan Shen, Keith Demarest, Bruce Conway, David McComsey
  • Substituted pyrroline kinase inhibitors
    Publication number: 20060205763
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
    Type: Application
    Filed: May 17, 2006
    Publication date: September 14, 2006
    Inventors: Han-Cheng Zhang, Gee-Hong Kuo, Bruce Maryanoff, Hong Ye, David O'Neill, Lan Shen, Keith Demarest, Bruce Conway, David McComsey
  • Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
    Publication number: 20060041008
    Abstract: The present invention is directed to novel sulfamide and sulfamate derivatives, pharmaceutical compositions containing them and their use in the treatment of epilepsy and related disorders.
    Type: Application
    Filed: June 16, 2005
    Publication date: February 23, 2006
    Inventors: David McComsey, Michael Parker, Allen Reitz, Bruce Maryanoff
  • Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
    Publication number: 20050282887
    Abstract: The present invention is directed to novel sulfamide and sulfamate derivatives, pharmaceutical compositions containing them and their use in the treatment of epilepsy and related disorders.
    Type: Application
    Filed: June 16, 2005
    Publication date: December 22, 2005
    Inventors: David McComsey, Michael Parker, Allen Reitz, Bruce Maryanoff
  • Indazolyl-substituted pyrroline compounds as kinase inhibitors
    Publication number: 20050004202
    Abstract: The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Application
    Filed: August 2, 2004
    Publication date: January 6, 2005
    Inventors: Han-Cheng Zhang, Bruce Maryanoff, Bruce Conway, Kimberly White, Hong Ye, Leonard Hecker, David McComsey
  • Heterocyclic derivatives useful in treating central nervous system disorders
    Patent number: 5968946
    Abstract: This invention relates to a series of substituted 3-oxo-pyrrolo[1,2-a]imidazopyridine derivatives of the formula 1 ##STR1## where X.sub.1 -X.sub.4, R.sub.1, R.sub.2 and Ar are defined herein. In addition the invention relates to pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention are ligands for the benzodiazepine site on the GABA-A receptor and display anxiolytic and anticonvulsant activity in animal models.
    Type: Grant
    Filed: October 5, 1998
    Date of Patent: October 19, 1999
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Bruce E. Maryanoff, David McComsey, James J. McNally, Samuel O. Nortey, Allen B. Reitz