Abstract: Disclosed herein is a class of molecules termed remodilins that are effective in treating asthma, pulmonary fibrosis, and associated disorders. The molecules ameliorate asthma and pulmonary fibrosis symptoms by various mechanisms, including inhibiting airway smooth muscle contractile protein accumulation, reducing airway constrictor hyperresponsiveness, inhibiting bronchial fibroblast transformation into myofibroblasts, and/or treating or preventing airway or pulmonary fibrosis.

Abstract: Disclosed herein is a class of molecules termed remodilins that inhibit serum response factor (SRF). By inhibiting SRF, a number of downstream pathways can be targeted. The remodilins can be used to treat glaucoma, inhibit tumor cell growth, inhibit tumor metastasis, inhibit hypoxia-induced response, and/or reduce cellular metabolism.

Abstract: Disclosed herein is a class of molecules termed remodilins that are effective in treating asthma, pulmonary fibrosis, and associated disorders. The molecules ameliorate asthma and pulmonary fibrosis symptoms by various mechanisms, including inhibiting airway smooth muscle contractile protein accumulation, reducing airway constrictor hyperresponsiveness, inhibiting bronchial fibroblast transformation into myofibroblasts, and/or treating or preventing airway or pulmonary fibrosis.

Abstract: Disclosed herein is a class of molecules termed remodilins that inhibit serum response factor (SRF). By inhibiting SRF, a number of downstream pathways can be targeted. The remodilins can be used to treat glaucoma, inhibit tumor cell growth, inhibit tumor metastasis, inhibit hypoxia-induced response, and/or reduce cellular metabolism.

Abstract: An apparatus, according to an exemplary aspect of the present disclosure includes, among other things, a clip body having a vehicle side and a panel side. A first clip is on the vehicle side and a second clip is on the panel side. A seal is on the vehicle side. A method according to an exemplary aspect of the present disclosure includes, among other things, attaching the first clip to a vehicle body, and subsequently attaching a panel to the second clip such that the seal is positioned between the clip body and the vehicle body.

Abstract: Methods of generating structural models of highly deviated or horizontal wells may be generated from the measurement of true stratigraphic thickness in three dimensions (TST3D). In one aspect, methods may include generating a structural model from one or more deviation surveys of a horizontal well, one or more single channel log measurements, and a three-dimensional reference surface.

Abstract: An apparatus, according to an exemplary aspect of the present disclosure includes, among other things, a clip body having a vehicle side and a panel side. A first clip is on the vehicle side and a second clip is on the panel side. A seal is on the vehicle side. A method according to an exemplary aspect of the present disclosure includes, among other things, attaching the first clip to a vehicle body, and subsequently attaching a panel to the second clip such that the seal is positioned between the clip body and the vehicle body.

Abstract: A device for measuring tissue hardness of a subject comprising: a housing, the housing having a proximal end and a distal end; a contact probe configured to contact tissue arranged on the distal end of the housing; a sensor assembly configure to measure tissue hardness disposed within the housing; a microprocessor configured to receive input from the sensor assembly; a force transduction assembly disposed within the housing; a microprocessor receiving input from the displacement sensor and the force sensor; and a display, receiving input from the microprocessor, configured to display information to a user on the proximal end of the housing.

Abstract: Methods of generating structural models of highly deviated or horizontal wells may be generated from the measurement of true stratigraphic thickness in three dimensions (TST3D). In one aspect, methods may include generating a structural model from one or more deviation surveys of a horizontal well, one or more single channel log measurements, and a three-dimensional reference surface.

Abstract: Linking multiple identities from a single service includes for a user of a single service having multiple identities within the single service, authenticating a primary identity having a first buddy list associated with an account, authenticating a secondary identity having a second buddy list associated with the account, and creating an association between the primary identity and the secondary identity, where the primary identity and the secondary identity simultaneously share a common graphical user interface such that the primary identity interacts with the first buddy list and the secondary identity interacts with the second buddy list using the common graphical user interface.

Abstract: A computer-implemented method is provided that automatically characterizes and verifies stationarity of a training image for use in multipoint geostatistical analysis. The stationarity is preferably characterized by statistical measures of orientation stationarity, scale stationarity, and category distribution stationarity.

Abstract: An extermination device for exterminating pests includes a holder, trigger mechanism and a resilient ring mounted on the holder. When a pest actuates the trigger mechanism, the ring is released from the holder onto the pest, thereby killing the pest in a humane manner. A cover may be provided to protect the trigger mechanism from dirt and animals larger than target pest size. A loading device having a tapering body adapted to allow a resilient ring to be expanded from the narrow end to the wide end of the tapering body, wherein the wide end includes a formation adapted to engage with a holder of an extermination device.

Abstract: Aqueous corrosion inhibitor compositions, preferably storage-stable, useful in acidic cleaning solutions for cleaning the surfaces of metal, comprising reaction products of at least one rosin amine component, at least one non-flammable liquid ketone component, at least one carboxylic acid component, at least one paraformaldehyde component and water; aqueous acidic cleaners prepared therefrom; and methods of their use. The inventive corrosion inhibitor compositions are made by a simple process which reduces the presence of toxic and/or flammable raw materials, co-products, residual reactants and chloride ion while providing acid inhibition in aqueous acidic cleaners.

Abstract: A computer-implemented method is provided that automatically characterizes and verifies stationarity of a training image for use in multipoint geostatistical analysis. The stationarity is preferably characterized by statistical measures of orientation stationarity, scale stationarity, and category distribution stationarity.

Abstract: A vehicle occupant protection system includes a plurality of inflatable devices, at least one fluid source for supplying a pressurized fluid for the vehicle occupant protection system, and at least one gas-tight manifold coupled to the at least one fluid source for receiving pressurized fluid from the at least one fluid source. The at least one manifold is also coupled to the plurality of inflatable devices such that, upon activation of the vehicle occupant protection system, the plurality of inflatable devices receive from the at least one manifold sufficient pressurized fluid to inflate the plurality of inflatable devices.

Abstract: A gas generating system for use in an inflatable vehicle occupant protection system is provided wherein an end closure is coupled to an outer housing at a first end, in a metal-to-metal seal. The gas generating system may also include a baffle system having a plurality of flow orifices defining a flow path for generated gases through an interior of the gas generating system, and a plurality of particulate aggregation surfaces positioned along the flow path of the gases for changing a flow direction of gases impinging on the aggregation surfaces. Each aggregation surface of the plurality of aggregation surfaces is oriented such that a difference between a flow direction of the gases prior to impinging on the aggregation surface and a flow direction of the gases after impinging on the aggregation surface is at least approximately 90°, wherein particulates in gases impinging on the aggregation surfaces aggregate on the surfaces.

Abstract: Coaching methods and systems are provided in which assessment data is received from a user, the assessment data is used along with course selection rules to select a plurality of courses for the user, and a plurality of electronic messages comprising content of the plurality of courses is sent to the user on a scheduled basis.

Abstract: Aqueous concentrates of non-toxic corrosion inhibitors, preferably storage-stable, useful in acidic cleaning solutions for cleaning the surfaces of metal that contacts food or potable water, the concentrates comprising at least one polymer, which may be protein-derived or synthetic; at least one iodine ion providing compound; an acidifier; and optionally, at least one anionic, nonionic or amphoteric surfactant; at least one coupling agent; and a pH adjuster; the concentrates being substantially free of nonylphenol derivatives and compounds containing elemental iodine and providing an improved acid inhibition and less foaming than similar compositions comprising nonylphenol derivatives and elemental iodine when mixed with aqueous acidic cleaners; acidic solutions prepared therefrom; and methods of their use.