Patents by Inventor David McGowan

David McGowan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10272085
    Abstract: This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.
    Type: Grant
    Filed: July 13, 2016
    Date of Patent: April 30, 2019
    Assignee: Janssen Sciences Ireland UC
    Inventors: David McGowan, Pierre Jean-Marie Bernard Raboisson, Werner Embrechts, Tim Hugo Maria Jonckers, Stefaan Julien Last, Serge Maria Aloysius Pieters, Jaromir Vlach
  • Publication number: 20180207155
    Abstract: This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.
    Type: Application
    Filed: January 10, 2018
    Publication date: July 26, 2018
    Inventors: David McGOWAN, Pierre Jean-Marie Bernard Raboisson, Werner Embrechts, Tim Hugo Maria Jonckers, Stefaan Julien Last, Serge Maria Aloysius Pieters, Jaromir Vlach
  • Patent number: 9584055
    Abstract: A voltage regulator system for regulating an output voltage of a genset includes a voltage regulator for reducing terminal voltage in response to a reduction in terminal frequency. A plurality of under-frequency roll-off (UFRO) states is provided in the voltage regulator, with each UFRO state being configured to implement a UFRO characteristic. An operational signal indicative of an operating condition of the genset forms the basis for selection of the UFRO characteristic.
    Type: Grant
    Filed: July 17, 2012
    Date of Patent: February 28, 2017
    Assignee: Caterpillar (NI) Limited
    Inventors: Alan Cooper, Keith Chambers, David McGowan, John Morrow
  • Patent number: 9324478
    Abstract: A high speed cable with terminating assemblies at the respective ends of the cable includes a ground wire, one or more signal wires, and a conductive layer enclosing the ground wire and the signal wires. The ground wire as well as the signal wires and the conductive layer extend into the terminating assemblies, in each of which corresponding inductive elements are coupled between the conductive layer and the ground wire. In each terminating assembly, the ground wire is shunted to the conductive layer by inductive elements, thus providing added low frequency connectivity in the cable, while at the same time blocking high frequency noise energy that may be present in the ground wire and preventing it from being coupled into, and transmitted through, the conductive layer.
    Type: Grant
    Filed: August 29, 2013
    Date of Patent: April 26, 2016
    Inventors: John Martin Horan, David McGowan, Padraig McDaid
  • Publication number: 20150236630
    Abstract: A voltage regulator system for regulating an output voltage of a genset includes a voltage regulator for reducing terminal voltage in response to a reduction in terminal frequency. A plurality of under-frequency roll-off (UFRO) states is provided in the voltage regulator, with each UFRO state being configured to implement a UFRO characteristic. An operational signal indicative of an operating condition of the genset forms the basis for selection of the UFRO characteristic.
    Type: Application
    Filed: July 17, 2012
    Publication date: August 20, 2015
    Applicant: Caterpillar (NI) Limited
    Inventors: Alan Cooper, Keith Chambers, David McGowan, John Morrow
  • Patent number: 9045463
    Abstract: Inhibitors of HCV replication of formula I including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein R and R* have the meaning defined in the claims. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HCV inhibitors, in the treatment or prophylaxis of HCV.
    Type: Grant
    Filed: August 6, 2010
    Date of Patent: June 2, 2015
    Assignee: Janssen R&D Ireland
    Inventors: David McGowan, Samuel Dominique Demin, Stefaan Julien Last, Koen Vandyck, Pierre Jean-Marie Bernard Raboisson
  • Patent number: 8916575
    Abstract: This invention relates to quinazoline derivatives, processes for their preparation, pharmaceutical compositions, and their use in therapy of disorders in which the modulation of toll-like-receptors is involved.
    Type: Grant
    Filed: May 18, 2012
    Date of Patent: December 23, 2014
    Assignee: Janssen R&D Ireland
    Inventors: David McGowan, Pierre Jean-Marie Bernard Raboisson, Tim Hugo Maria Jonckers, Stefaan Julien Last, Werner Embrechts, Serge Maria Aloysius Pieters
  • Publication number: 20140073642
    Abstract: This invention relates to quinazoline derivatives, processes for their preparation, pharmaceutical compositions, and their use in therapy of disorders in which the modulation of toll-like-receptors is involved.
    Type: Application
    Filed: May 18, 2012
    Publication date: March 13, 2014
    Applicant: Janssen R&D Ireland
    Inventors: David McGowan, Pierre Jean-Marie Bernard Raboisson, Tim Hugo Maria Jonckers, Stefaan Julien Last, Werner Embrechts, Serge Maria Aloysius Pieters
  • Publication number: 20140045849
    Abstract: This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.
    Type: Application
    Filed: April 10, 2012
    Publication date: February 13, 2014
    Inventors: David McGowan, Pierr Jeane-Marie Bernar Raboisson, Werner Embrechts, Tim Hugo Maria Jonckers, Stefaan Julien Last, Serge Maria Aloysius Pieters, Jaromir Vlach
  • Patent number: 8623899
    Abstract: Inhibitors of HCV replication of formula I including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein R and R? have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HCV inhibitors, in HCV therapy.
    Type: Grant
    Filed: August 6, 2010
    Date of Patent: January 7, 2014
    Assignee: Janssen Research & Development Ireland
    Inventors: David McGowan, Samuel Dominique Demin, Stefaan Julien Last, Koen Vandyck, Pierre Jean-Marie Bernard Raboisson
  • Publication number: 20140000924
    Abstract: A high speed cable with terminating assemblies at the respective ends of the cable includes a ground wire, one or more signal wires, and a conductive layer enclosing the ground wire and the signal wires. The ground wire as well as the signal wires and the conductive layer extend into the terminating assemblies, in each of which corresponding inductive elements are coupled between the conductive layer and the ground wire. In each terminating assembly, the ground wire is shunted to the conductive layer by inductive elements, thus providing added low frequency connectivity in the cable, while at the same time blocking high frequency noise energy that may be present in the ground wire and preventing it from being coupled into, and transmitted through, the conductive layer.
    Type: Application
    Filed: August 29, 2013
    Publication date: January 2, 2014
    Inventors: John Martin Horan, David McGowan, Padraig McDaid
  • Patent number: 8479248
    Abstract: A system for providing a power signal of a predetermined voltage to an input of a High Definition Multimedia Interface (HDMI) sink device is provided. The system includes an electronic device, generating HDMI signals transmitted on at least one differential signal line to another input of the HDMI sink device, and a startup circuit, providing the power signal of the predetermined voltage. The startup circuit includes a power harvesting circuit for obtaining an electrical power of a lower voltage, lower than the predetermined voltage, from at least one of the HDMI signals on the another input, and a voltage raiser circuit increasing the lower voltage to the predetermined voltage. A corresponding electronic cable containing the start-up circuit is also provided.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: July 2, 2013
    Inventors: John Martin Horan, David McGowan
  • Patent number: 8436036
    Abstract: Compounds of the formula I: including any possible stereoisomers thereof, or a pharmaceutically acceptable salt and/or solvate thereof, as well as pharmaceutical formulations and the use of compounds of formula I as HCV inhibitors.
    Type: Grant
    Filed: April 23, 2010
    Date of Patent: May 7, 2013
    Assignee: Janssen R&D Ireland
    Inventors: Samuel Dominique Demin, David McGowan, Stefaan Julien Last, Pierre Jean-Marie Bernard Raboisson
  • Patent number: 8272023
    Abstract: A High Definition Multimedia Interface (HDMI) cable carries high speed encoded data, which are transmitted differentially over data channels, along with a clock. A Mobile High-Definition Link (MHL) cable carries high speed data which are multiplexed to achieve smaller connectors with fewer pins. A MHL-to-HDMI cable is proposed, which includes an embedded MHL to HDMI adapter device for demultiplexing the received MHL-formatted signal and outputting an HDMI-formatted signal. The embedded circuit is powered by a combination of power sources, the power being harvested from the high-speed HDMI signals themselves, including a startup circuit harvesting power from a low speed HDMI signal when power from the high-speed HDMI signals is not available.
    Type: Grant
    Filed: June 9, 2010
    Date of Patent: September 18, 2012
    Assignee: Redmere Technology Ltd.
    Inventors: John Martin Horan, David McGowan
  • Publication number: 20120172368
    Abstract: Inhibitors of HCV replication of formula I including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein R and R? have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use in HCV therapy.
    Type: Application
    Filed: September 2, 2010
    Publication date: July 5, 2012
    Inventors: Koen Vandyck, David McGowan, Pierre Jean-Marie Bernard Raboisson
  • Patent number: 7674907
    Abstract: The present invention relates to furanopyridine compounds having the general Formula I: and stereoisomers, tautomers, solvates, pharmaceutically acceptable salts and derivatives, and prodrugs thereof.
    Type: Grant
    Filed: July 18, 2005
    Date of Patent: March 9, 2010
    Assignee: Amgen Inc.
    Inventors: Joseph J. Nunes, Matthew W. Martin, Ryan White, David McGowan, Jean E. Bemis, Frank Kayser, Jiasheng Fu, Jinqian Liu, XianYun Jiao
  • Publication number: 20070072862
    Abstract: The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including autoimmune disease and inflammation. In one embodiment, the compounds have a general Formula I wherein A1, A2, A3, A4, L, R1, R2 and R3 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of the present invention, methods of use such as treatment of Lck and/or c-Kit kinase mediated diseases by administering the compounds of the invention, or compositions including one or more compounds of the invention, and intermediates and processes useful for the preparation of compounds of the present invention.
    Type: Application
    Filed: August 11, 2006
    Publication date: March 29, 2007
    Inventors: Erin Dimauro, Jean Bemis, Stuart Chaffee, Ning Chen, Essu Hu, Roxanne Kunz, Matthew Martin, David McGowan, Shannon Rumfelt
  • Publication number: 20070054916
    Abstract: The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation, cancer and related conditions. The compounds have a general Formula I wherein A1, A2, A3, B, R1, R2, R3 and R4 are defined herein. Accordingly, the invention also comprises pharmaceutical compositions comprising the compounds of the invention, methods for the prophylaxis and treatment of kinase mediated diseases using the compounds and compositions of the invention, and intermediates and processes useful for the preparation of compounds of the invention.
    Type: Application
    Filed: September 30, 2005
    Publication date: March 8, 2007
    Inventors: Vinod Patel, Joseph Kim, Stephanie Geuns-Meyer, Stuart Chaffee, Victor Cee, Brian Hodous, Steven Bellon, Jean-Christophe Harmange, Philip Olivieri, Maya Thaman, Erin DiMauro, John Buchanan, David McGowan, Brian Albrecht, Holly Deak, Jean Bemis, Ryan White, Matthew Martin, Gregory Habgood, Paul Tempest, Craig Masse, William Buckner, Bradley Herberich, Russell Graceffa, Dawei Zhang, Shimin Xu, Kelvin Sham, Robert Rzasa, James Falsey, Partha Chakrabarti, Guo-Qiang Cao, Susan Tomlinson, Liping Pettus, Adrian Smith, Nick Paras, Gang Liu, Frenel DeMorin, Andrew Tasker, Anthony Reed
  • Patent number: 7186090
    Abstract: An article of manufacture having a nominal profile substantially in accordance with Cartesian coordinate values of X, Y and Z set forth in a table. The table selected from the group of tables consisting of TABLES 1S–16S, 1R–17R, and IGV. Wherein X and Y are distances in inches which, when connected by smooth continuing arcs, define airfoil profile sections at each distance Z in inches. The profile sections at the Z distances being joined smoothly with one another to form a complete airfoil shape.
    Type: Grant
    Filed: November 12, 2004
    Date of Patent: March 6, 2007
    Assignee: General Electric Company
    Inventors: Steven Eric Tomberg, Roger Beharrysingh, Timothy E. DeJoris, William J. Miller, Paul Deivernois, Venkata Siva P. Chaluvadi, Adrian Mircea Mistreanu, Michael James Dutka, Nathan S. Race, Jeffrey Boyd, Christopher David McGowan, Peter Gaines Cleveland, Jason Thomas Harrell, Carl G. Schott, John David Stampfli, Ronald Stuart Denmark, Steven Mark Schirle, Jennifer B. Michenfelder, John F. Ryman
  • Publication number: 20060241115
    Abstract: Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
    Type: Application
    Filed: January 24, 2005
    Publication date: October 26, 2006
    Inventors: Michele Potashman, Tae-Seong Kim, Steven Bellon, Shon Booker, Yuan Cheng, Joseph Kim, Andrew Tasker, Ning Xi, Shimin Xu, Jean-Christophe Harmange, George Borg, Matthew Weiss, Brian Hodous, Russell Graceffa, William Buckner, Craig Masse, Deborah Choquette, Matthew Martin, Julie Germain, Lucian DiPietro, Stuart Chaffee, Joseph Nunes, John Buchanan, Gregory Habgood, David McGowan, Douglas Whittington