Abstract: This invention relates to the co-expression of KCNQ2 and KCNQ3 genes in an appropriate mammalian cell line (e.g., HEK 293E) to provide a preparation which could be used as a high-throughput screen for the discovery of agents that are either agonists or antagonists of the expressed potassium channel. Mutations in the voltage-gated potassium channel genes, KCNQ2 and KCNQ3, have been linked to inherited forms of epilepsy in humans. One or both of these genes are believed to encode the molecular identity of the M channel. Agonists of the M channel may be effective in the treatment of epilepsy, anxiety, insomnia or other hyperexcitability disorders whereas antagonists may be effective in the treatment of Alzheimer's disease, peripheral neuropathy or other neurodegenerative diseases.

Abstract: The present invention relates to the correction of planar focus in an electronic still or video camera. The camera includes: a detector array an objective lens arranged to direct optical radiation from an object plane onto the detector the lens defining an optical axis of the camera and the object plane being at an oblique angle to the optical axis movement device to change the relative orientation of the detector with respect to the lens so that the detector and lens may be moved relatively toward or away from each other along the optical axis and also tilted with respect to each other with at least one degree of freedom and focus detection device connected to the detector to detect when a portion of an image falling on the detector is in focus.

Abstract: A flexible multi-strip closure is supported in a vertically hanging position by means on horizontally oriented structural beads attached to each strip, which beads are retained in a horizontally oriented, inverted U-shape channel which includes an entrapment portion for supporting the beads against vertical forces and at least one lip to eliminate stress concentrations in the flexible strips when they are flexed. Releasable means are provided adjacent at least one end of the channel to restrict horizontal movement of the beads and to allow removal of the beads with their attached strips for cleaning and replacement.