Abstract: Tellurium nanowires synthesized using green chemistry methods and having unique morphologies and functional properties are provided. The nanowires have a core of hexagonal crystal phase tellurium and a polymer coating, and can be used for treating cancer without apparent cytotoxicity toward normal human cells.

Abstract: Provided herein are compounds identified as inhibitors of HDAC6 activity having the formula: or a pharmaceutically acceptable salt thereof, that can be used to treat various diseases and disorders.

Abstract: Disclosed herein are methods, systems, and computer-readable media for integrating a particular external application programming interface (API) with a natural language model user interface. In one embodiment, a method includes receiving a first input at the natural language model user interface, determining the first input includes a request to integrate the particular external application programming interface (API) with the natural language model user interface, identifying the particular external API based on the received input, integrating the particular external API with the natural language model user interface, accessing the particular external API based on the first input or a second input at the natural language model user interface, and transmitting, based on the accessing, a response message to the natural language model user interface, the response message including a result of the accessing.

Abstract: A continuous perfusion bioreactor for microbial synthesis of metallic nanoparticles provides synthesis of nanoparticles without washout of the microbial cells. The perfusion bioreactor includes an inlet fluidically coupled to a holding compartment with a first flow barrier, which disperses the medium into a reaction compartment suitable for culture of microbial cells which synthesize nanoparticles. A second flow barrier in the reaction compartment prevents washout of the microbial cells but enables collection of the nanoparticles suspended in depleted nutrient medium.

Abstract: Methods disclosed herein provide for an environmentally-friendly approach that employ citric extracts from fruits as unique reducing and stabilizing agents for making a tellurium nanomaterial. A particular method of making a tellurium nanomaterial includes combining citrus fruit extract with a tellurium salt to form a mixture of citrus fruit extract and dissolved tellurium salt; and heating the mixture of citrus fruit extract and dissolved tellurium salt, thereby making the tellurium nanomaterial. The resulting nanoparticles exhibit enhanced and desirable biomedical properties toward treatment of both infectious diseases and cancer.

Abstract: Green-synthesized tellurium nanowires (GREEN-TeNWs) are generated using a biopolymer as a unique reducing agent, purified, and used as a template for the growth of coated palladium nanoparticles (PdNPs) and platinum nanoparticles (PtNPs) on top of the GREEN-TeNWs, in a reaction that can take place in seconds, with no need for high temperature, stirring, or for additional reducing agent. The heterogeneous structure can contain palladium oxide or platinum oxide. The green-synthesized PdNPs-TeNWs (palladium nanoparticles with tellurium nanowires) and PtNPs-TeNWs (platinum nanoparticles with tellurium nanowires) show potential biomedical applications as antibacterial, anticancer, and antioxidant agents, and show low cytotoxicity for healthy human cells.

Abstract: Human dermal fibroblasts (HDF) and melanoma (MEL) cells are used herein for synthesis of metal nanoparticles. For example, synthesis of nanoparticles of gold (Au), palladium (Pd), platinum (Pt), and bimetallic formulations of gold-palladium (AuPd) and gold-platinum (AuPt) is demonstrated with HDF and MEL using a straightforward, eco-friendly and cost-effective approach. The nanostructures are purified and used in biomedical tests, which show selective behavior. The production of nanoparticles allows for stopping of the growth of cancer cells and the ability of new healthy cells to grow on top. The production of nanoparticles with the cells allows for an environmental-resistance behavior within the cells, showing the ability to stand for extreme environmental conditions.

Abstract: Selenium (Se) nanostructures are synthesized using bacteria, and the synthetic method provides options for specific functionalization of the nanostructures, targeting, as well as options for crystal form of and for additives to the composition. In addition to drug delivery and imaging options, the synthesized Se nanostructures provide methods of inhibiting drug resistant bacterial cells and cancer cells without cytotoxicity towards normal human cells and dermal fibroblasts. The green chemistry methods for synthesizing Se nanostructures do not produce toxic byproducts and do not require toxic reagents in comparison to traditional chemical synthetic methods for making Se nanostructures, while simultaneously producing new therapeutic benefits and treatments.

Abstract: Tellurium (Te) nanostructures are synthesized using green aloe vera chemistry methods, and the synthesized Te tructures provide methods of inhibiting bacterial cells and cancer cells without cytotoxicity towards normal cells. The aloe vera chemistry methods for synthesizing Te nanostructures do not produce toxic byproducts and do not require toxic reagents in comparison to traditional chemical synthetic methods for making Te nanostructures.

Abstract: An electrode humidifier device having a cartridge and a reconfigurable steam nozzle, connected to the cartridge that may be changeable between a direct and a remote mounting. Fill and drain valves on a manifold may be operated to add or drain water, respectively, in the cartridge. A sensor may indicate a water level in the cartridge. A controller may be connected to the sensor, and the fill and drain valves. A steam output capacity of the cartridge may be maintained at a predetermined magnitude by controlling the level of water with a controller. The cartridge may have one or more handles for easily inserting or removing the cartridge in a housing. The manifold may be installed in the drain pan for easier cartridge replacement. The humidifier device may be directly mounted on an air duct of a heating system or can be installed remotely.

Abstract: This sealing device for a railway, the railway including a housing extending between a side face of a rail and a side wall of a slot reserved in the ground for housing said rail, is characterized in that it is a sealing device inserted in the housing and fixed in the housing by a suitable putty, and in that it is a resiliently deformable profile, to be able to be inserted under stress in the housing and to be pressed against the side face of the rail and the side wall of the slot.

Abstract: Methods disclosed herein provide for an environmentally-friendly approach that employ citric extracts from fruits as unique reducing and stabilizing agents for making a tellurium nanomaterial. A particular method of making a tellurium nanomaterial includes combining citrus fruit extract with a tellurium salt to form a mixture of citrus fruit extract and dissolved tellurium salt; and heating the mixture of citrus fruit extract and dissolved tellurium salt, thereby making the tellurium nanomaterial. The resulting nanoparticles exhibit enhanced and desirable biomedical properties toward treatment of both infectious diseases and cancer.

Abstract: Tellurium nanowires synthesized using green chemistry methods and having unique morphologies and functional properties are provided. The nanowires have a core of hexagonal crystal phase tellurium and a polymer coating, and can be used for treating cancer without apparent cytotoxicity toward normal human cells.

Abstract: A nanoparticle formulation of tellurium nanorods. The tellurium nanoparticles are prepared using polyvinylpyrrolidone (PVP), which creates a functionalized coating on the outside of the particles. The nanorods have been shown to have antibacterial properties against both Gram-positive and Gram-negative bacteria, as well as anticancer properties when tested with human melanoma cells.

Abstract: A system and method for isolating secure communication events from a non-secure application are described herein. The method can include the steps of intercepting a communication event from an external communications network or an external communications device and determining whether the communication event is a secure communication event. If the communication event is a secure communication event, the secure communication event can be processed by a secure application. In addition, the secure communication event can be prevented from being processed by the non-secure application.

Abstract: This sealing device for a railway, the railway including a housing extending between a side face of a rail and a side wall of a slot reserved in the ground for housing said rail, is characterized in that it is a sealing device inserted in the housing and fixed in the housing by a suitable putty, and in that it is a resiliently deformable profile, to be able to be inserted under stress in the housing and to be pressed against the side face of the rail and the side wall of the slot.

Abstract: An electrode humidifier device having a cartridge and a reconfigurable steam nozzle, connected to the cartridge that may be changeable between a direct and a remote mounting. Fill and drain valves on a manifold may be operated to add or drain water, respectively, in the cartridge. A sensor may indicate a water level in the cartridge. A controller may be connected to the sensor, and the fill and drain valves. A steam output capacity of the cartridge may be maintained at a predetermined magnitude by controlling the level of water with a controller. The cartridge may have one or more handles for easily inserting or removing the cartridge in a housing. The manifold may be installed in the drain pan for easier cartridge replacement. The humidifier device may be directly mounted on an air duct of a heating system or can be installed remotely.

Abstract: A system and method for isolating secure communication events from a non-secure application are described herein. The method can include the steps of intercepting a communication event from an external communications network or an external communications device and determining whether the communication event is a secure communication event. If the communication event is a secure communication event, the secure communication event can be processed by a secure application. In addition, the secure communication event can be prevented from being processed by the non-secure application.

Abstract: A method and system for data usage accounting are described herein. As an example, the method can be practiced in a setting that includes both secure applications and unsecure applications. Via one of the secure applications, a request to access data can be received in which the request is intended for a content provider via a system service. The request that is intended for the content provider via the system service can be intercepted and modified, which can cause the system service to direct the request back to the secure application instead of the content provider. In addition, a connection can be established with the content provider for the request through the secure application to enable data usage accounting of data that is returned by the content provider.

Abstract: A method and system of selectively permitting a non-secure application to communicate with a secure application are described herein. The method can be practiced in a system that support an environment designed to restrict secure applications from processing requests from non-secure applications. In particular, a request can be received from a non-secure application by a system framework and, through the system framework, it can be determined that a secure application is capable of processing the request. The request can be delegated from the system framework to a secure framework. In addition, through the secure framework, it can be determined whether the non-secure application is an authorized non-secure application. If the non-secure application is an authorized non-secure application, the secure application can be permitted to process the request from the non-secure application.