Patents by Inventor David Meloni

David Meloni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TOPICAL SKIN FORMULATIONS OF A PHARMACEUTICALLY ACCEPTABLE SALT OF RUXOLITINIB
    Publication number: 20260053743
    Abstract: This invention relates to topical skin formulations comprising a pharmaceutically acceptable salt of ruxolitinib, and use in the treatment of skin disorders.
    Type: Application
    Filed: August 25, 2025
    Publication date: February 26, 2026
    Inventors: Russell ELLIOTT, Zhongjiang JIA, Gary LAWRENCE, Mei LI, Pingli LIU, Weiguo LIU, David MELONI, Yongchun PAN, Huifang WU, Jiacheng ZHOU
  • PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS
    Publication number: 20250340559
    Abstract: The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.
    Type: Application
    Filed: January 8, 2025
    Publication date: November 6, 2025
    Inventors: Jiacheng ZHOU, Qiyan Lin, Brian W. Metcalf, David Meloni, Yongchun Pan, James D Rodgers, Haisheng Wang
  • SOLID FORMS OF JAK INHIBITOR AND PROCESS OF PREPARING THE SAME
    Publication number: 20250270221
    Abstract: The present disclosure is related to solid forms of ruxolitinib di-hydrate and ruxolitinib free base, process of preparing the same, and compositions comprising the same.
    Type: Application
    Filed: May 7, 2025
    Publication date: August 28, 2025
    Inventors: Zhongjiang Jia, Weiguo Liu, Pingli Liu, David Meloni, Yongchun Pan, Jiacheng Zhou, Travis Houston
  • SALTS AND PROCESSES OF PREPARING A PI3K INHIBITOR
    Publication number: 20250129079
    Abstract: The present application provides processes for preparing (R)-4-(3-((S)-1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)pyrrolidin-2-one, which is useful as an inhibitor phosphoinositide 3-kinase-delta (PI3K?), as well as a salt form and intermediates related thereto.
    Type: Application
    Filed: May 8, 2024
    Publication date: April 24, 2025
    Inventors: Lei Qiao, Lingkai Weng, Chongsheng Eric Shi, David Meloni, Qiyan Lin, Michael Xia, Vaqar Sharief, William Frietze, Zhongjiang Jia, Yongchun Pan, Pingli Liu, Tai-Yuen Yue, Jiacheng Zhou, Jianji Wang
  • Process for preparing compositions comprising an enantiomeric excess of a substituted pyrrolo[2,3-d]pyrimidine
    Patent number: 12247030
    Abstract: The present invention is related to processes for preparing a composition comprising an enantiomeric excess of a substituted pyrrolo[2,3-d]pyrimidine utilizing chiral acids.
    Type: Grant
    Filed: February 16, 2021
    Date of Patent: March 11, 2025
    Assignees: Incyte Holdings Corporation, Incyte Corporation
    Inventors: Jiacheng Zhou, David Meloni, Yongchun Pan, Mei Li
  • SOLID FORMS OF JAK INHIBITOR AND PROCESS OF PREPARING THE SAME
    Publication number: 20250026760
    Abstract: The present disclosure is related to solid forms of ruxolitinib di-hydrate and ruxolitinib free base, process of preparing the same, and compositions comprising the same.
    Type: Application
    Filed: September 25, 2024
    Publication date: January 23, 2025
    Inventors: Zhongjiang Jia, Weiguo Liu, Pingli Liu, David Meloni, Yongchun Pan, Jiacheng Zhou, Travis Houston
  • PROCESS AND INTERMEDIATES FOR PREPARING A JAK INHIBITOR
    Publication number: 20240368171
    Abstract: The present disclosure is related to processes for preparing baricitinib, salts thereof, and related synthetic intermediate compounds and salts thereof.
    Type: Application
    Filed: July 16, 2024
    Publication date: November 7, 2024
    Inventors: Jiacheng Zhou, Shili Chen, Zhongjiang Jia, Pingli Liu, David Meloni, Yongchun Pan, Naijing Su, Michael Xia
  • Process and intermediates for preparing a JAK inhibitor
    Patent number: 12071439
    Abstract: The present disclosure is related to processes for preparing baricitinib, salts thereof, and related synthetic intermediate compounds and salts thereof.
    Type: Grant
    Filed: July 11, 2022
    Date of Patent: August 27, 2024
    Assignee: Incyte Corporation
    Inventors: Jiacheng Zhou, Shili Chen, Zhongjiang Jia, Pingli Liu, David Meloni, Yongchun Pan, Naijing Su, Michael Xia
  • Salts and processes of preparing a PI3K inhibitor
    Patent number: 12024522
    Abstract: The present application provides processes for preparing (R)-4-(3-((S)-1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)pyrrolidin-2-one, which is useful as an inhibitor phosphoinositide 3-kinase-delta (PI3K?), as well as a salt form and intermediates related thereto.
    Type: Grant
    Filed: July 1, 2021
    Date of Patent: July 2, 2024
    Assignees: Incyte Corporation, Incyte Holdings Corporation
    Inventors: Lei Qiao, Lingkai Weng, Chongsheng Eric Shi, David Meloni, Qiyan Lin, Michael Xia, Vaqar Sharief, William Frietze, Zhongjiang Jia, Yongchun Pan, Pingli Liu, Tai-Yuen Yue, Jiacheng Zhou, Jianji Wang
  • SOLID FORMS OF JAK INHIBITOR AND PROCESS OF PREPARING THE SAME
    Publication number: 20230399331
    Abstract: The present disclosure is related to solid forms of ruxolitinib di-hydrate and ruxolitinib free base, process of preparing the same, and compositions comprising the same.
    Type: Application
    Filed: June 14, 2023
    Publication date: December 14, 2023
    Inventors: Zhongjiang Jia, Weiguo Liu, Pingli Liu, David Meloni, Yongchun Pan, Jiacheng Zhou, Travis Houston
  • PROCESS AND INTERMEDIATES FOR PREPARING A JAK INHIBITOR
    Publication number: 20230059389
    Abstract: The present disclosure is related to processes for preparing baricitinib, salts thereof, and related synthetic intermediate compounds and salts thereof.
    Type: Application
    Filed: July 11, 2022
    Publication date: February 23, 2023
    Inventors: Jiacheng Zhou, Shili Chen, Zhongjiang Jia, Pingli Liu, David Meloni, Yongchun Pan, Naijing Su, Michael Xia
  • SALTS AND PROCESSES OF PREPARING A PI3K INHIBITOR
    Publication number: 20220024934
    Abstract: The present application provides processes for preparing (R)-4-(3-((S)-1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)pyrrolidin-2-one, which is useful as an inhibitor phosphoinositide 3-kinase-delta (PI3K?), as well as a salt form and intermediates related thereto.
    Type: Application
    Filed: July 1, 2021
    Publication date: January 27, 2022
    Inventors: Lei Qiao, Lingkai Weng, Chongsheng Eric Shi, David Meloni, Qiyan Lin, Michael Xia, Vaqar Sharief, William Frietze, Zhongjiang Jia, Yongchun Pan, Pingli Liu, Tai-Yuen Yue, Jiacheng Zhou
  • Processes for Preparing Jak Inhibitors and Related Intermediate Compounds
    Publication number: 20210253584
    Abstract: The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.
    Type: Application
    Filed: February 16, 2021
    Publication date: August 19, 2021
    Inventors: Jiacheng Zhou, Pingli Liu, Qiyan Lin, Brian W. Metcalf, David Meloni, Yongchun Pan, Michael Xia, Mei Li, Tai-Yuen Yue, James D. Rodgers, Haisheng Wang
  • Salts and processes of preparing a PI3K inhibitor
    Patent number: 11084822
    Abstract: The present application provides processes for preparing (R)-4-(3-((S)-1-(4-amino-3-methyl-1H-pyrazolo [3,4-d]pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)pyrrolidin-2-one, which is useful as an inhibitor phosphoinositide 3-kinase-delta (PI3K?), as well as a salt form and intermediates related thereto.
    Type: Grant
    Filed: June 21, 2019
    Date of Patent: August 10, 2021
    Assignee: Incyte Corporation
    Inventors: Lei Qiao, Lingkai Weng, David Meloni, Zhongjiang Jia, Jianji Wang, Jiacheng Zhou
  • SALTS AND PROCESSES OF PREPARING A PI3K INHIBITOR
    Publication number: 20190308979
    Abstract: The present application provides processes for preparing (R)-4-(3-((S)-1-(4-amino-3-methyl-1H-pyrazolo [3,4-d]pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)pyrrolidin-2-one, which is useful as an inhibitor phosphoinositide 3-kinase-delta (PI3K?), as well as a salt form and intermediates related thereto.
    Type: Application
    Filed: June 21, 2019
    Publication date: October 10, 2019
    Inventors: Lei Qiao, Lingkai Weng, David Meloni, Zhongjiang Jia, Jianji Wang, Jiacheng Zhou
  • Salts and processes of preparing a PI3K inhibitor
    Patent number: 10336759
    Abstract: The present application provides processes for preparing (R)-4-(3-((S)-1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)pyrrolidin-2-one, which is useful as an inhibitor phosphoinositide 3-kinase-delta (PI3K?), as well as a salt form and intermediates related thereto.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: July 2, 2019
    Assignee: Incyte Corporation
    Inventors: Lei Qiao, Lingkai Weng, David Meloni, Zhongjiang Jia, Jianji Wang, Jiacheng Zhou
  • Processes for preparing pyrazolyl-substituted pyrrolo[2,3-d]pyrimidines
    Patent number: 9908888
    Abstract: The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: March 6, 2018
    Assignees: Incyte Corporation, Incyte Holdings Corporation
    Inventors: Jiacheng Zhou, Pingli Liu, Qiyan Lin, Brian W. Metcalf, David Meloni, Yongchun Pan, Michael Xia, Mei Li, Tai-Yuen Yue, James D. Rodgers, Haisheng Wang
  • SALTS AND PROCESSES OF PREPARING A PI3K INHIBITOR
    Publication number: 20160257689
    Abstract: The present application provides processes for preparing (R)-4-(3-((S)-1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)pyrrolidin-2-one, which is useful as an inhibitor phosphoinositide 3-kinase-delta (PI3K?), as well as a salt form and intermediates related thereto.
    Type: Application
    Filed: February 26, 2016
    Publication date: September 8, 2016
    Inventors: Lei Qiao, Lingkai Weng, ChongShen Eric Shi, David Meloni, Qiyan Lin, Michael Xia, Vaqar Sharief, William Frietze, Zhongjiang Jia, Yongchun Pan, Pingli Liu, Tai-Yuen Yue, Jiacheng Zhou
  • Processes for preparing JAK inhibitors and related intermediate compounds
    Patent number: 9290506
    Abstract: The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.
    Type: Grant
    Filed: January 9, 2015
    Date of Patent: March 22, 2016
    Assignees: Incyte Corporation, Incyte Holdings Corporation
    Inventors: Jiacheng Zhou, David Meloni, Yongchun Pan, Mei Li, Pingli Liu, Brian W. Metcalf, Tai-Yuen Yue
  • Processes for preparing JAK inhibitors and related intermediate compounds
    Patent number: 9000161
    Abstract: The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.
    Type: Grant
    Filed: February 7, 2013
    Date of Patent: April 7, 2015
    Assignee: Incyte Corporation
    Inventors: Jiacheng Zhou, Pingli Liu, Qiyan Lin, David Meloni, Yongchun Pan, Michael Xia, Mei Li, Tai-Yuen Yue, Brian W. Metcalf