Patents by Inventor David Mertz

David Mertz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stably-inverted organoids and methods of producing and using the same
    Patent number: 12560592
    Abstract: An exemplary embodiment of the present disclosure provides a 3D structure comprising a tissue layer having a first surface defining an interior chamber and an opposing second surface supporting a first plurality of cells outwardly positioned from the interior chamber, wherein the interior chamber comprises an extracellular matrix mixture. The present disclosure also provides a method of making a 3D structure, the method comprising mixing an extracellular matrix mixture at a first temperature with a culture medium at a second temperature, the second temperature greater than the first temperature, culturing a first plurality of cells in the extracellular matrix mixture and culture medium, and forming a 3D structure having an interior chamber enclosed by the first plurality of cells configured to interface with an environment external to the 3D structure.
    Type: Grant
    Filed: May 21, 2021
    Date of Patent: February 24, 2026
    Assignee: Georgia Tech Research Corporation
    Inventors: Eric Scott Parigoris, Ji Hoon Lee, Soojung Lee, David Mertz, Shuichi Takayama
  • STABLY-INVERTED ORGANOIDS AND METHODS OF PRODUCING AND USING THE SAME
    Publication number: 20230194506
    Abstract: An exemplary embodiment of the present disclosure provides a 3D structure comprising a tissue layer having a first surface defining an interior chamber and an opposing second surface supporting a first plurality of cells outwardly positioned from the interior chamber, wherein the interior chamber comprises an extracellular matrix mixture. The present disclosure also provides a method of making a 3D structure, the method comprising mixing an extracellular matrix mixture at a first temperature with a culture medium at a second temperature, the second temperature greater than the first temperature, culturing a first plurality of cells in the extracellular matrix mixture and culture medium, and forming a 3D structure having an interior chamber enclosed by the first plurality of cells configured to interface with an environment external to the 3D structure.
    Type: Application
    Filed: May 21, 2021
    Publication date: June 22, 2023
    Inventors: Eric Scott Parigoris, Ji Hoon Lee, Soojung Lee, David Mertz, Shuichi Takayama