Patents by Inventor David Messersmith
David Messersmith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230339915Abstract: Novel compounds, compositions, and methods of using and preparing the same, which maybe useful for treating alpha-1 antitrypsin deficiency (AATD).Type: ApplicationFiled: April 2, 2021Publication date: October 26, 2023Inventors: Simon GIROUX, Michael Philip CLARK, Qing TANG, Philippe Marcel NUHANT, Peter JONES, David MESSERSMITH, Upul Keerthi BANDARAGE, Kevin Michael COTTRELL, Michael Aaron BRODNEY, Gabrielle Simone FLEMING, Jian WANG, Jinwang XU, Kevin Brett DANIEL, Michael John BOYD, Mark A. MORRIS, Nathan D. WAAL, Philip Noel COLLIER, Sarathy KESAVAN, Steven M. RONKIN, Hongbo DENG, Diane Marie BOUCHER, Lev T.D. FANNING, Amy B. HALL, Dennis James HURLEY, Mac Arthur JOHNSON, Jr., John Patrick MAXWELL, Rebecca Jane SWETT, Timothy Lewis TAPLEY, Stephen A. THOMSON, Veronique DAMAGNEZ
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Patent number: 10766869Abstract: The invention relates to triazole compounds of formula I and I? or pharmaceutically acceptable salts thereof, useful as modulators of demyelinating diseases: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention, methods of using the compositions and kits thereof in the treatment of various demyelinating and neurodegenerative diseases, including multiple sclerosis.Type: GrantFiled: October 17, 2018Date of Patent: September 8, 2020Assignee: VERTEX PHARMACEUTCALS INCORPORATEDInventors: Robert J. Davies, Jingrong Cao, Meghan Elise Cockerill, Philip Noel Collier, Elisabeth Doyle, James Daniel Frantz, Huai Gao, Brian Anthony Goldman, Ronald Lee Grey, Jr., Anne-Laure Grillot, Wenxin Gu, James A. Henderson, Raul Eduardo Krauss, Adrianne Lynn Kolpak, Yusheng Liao, Sanjay Shivayogi Magavi, David Messersmith, Albert Charles Pierce, Emanuele Perola, Elizabeth Jin-Sun Ryu, Joshua Syken, Jian Wang, Michael Paul DeNinno, Francois Maltais
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Publication number: 20190185436Abstract: The invention relates to triazole compounds of formula I and I? or pharmaceutically acceptable salts thereof, useful as modulators of demyelinating diseases: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention, methods of using the compositions and kits thereof in the treatment of various demyelinating and neurodegenerative diseases, including multiple sclerosis.Type: ApplicationFiled: October 17, 2018Publication date: June 20, 2019Inventors: Robert J. Davies, Jingrong Cao, Meghan Elise Cockerill, Philip Noel Collier, Elisabeth Doyle, James Daniel Frantz, Huai Gao, Brian Anthony Goldman, Ronald Lee Grey, JR., Anne-Laure Grillot, Wenxin Gu, James A. Henderson, Raul Eduardo Krauss, Adrianne Lynn Kolpak, Yusheng Liao, Sanjay Shivayogi Magavi, David Messersmith, Albert Charles Pierce, Emanuele Perola, Elizabeth Jin-Sun Ryu, Joshua Syken, Jian Wang, Michael Paul DeNinno, Francois Maltais
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Patent number: 10183933Abstract: The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3K?. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.Type: GrantFiled: May 23, 2017Date of Patent: January 22, 2019Assignee: Vertex Pharmaceuticals IncorporatedInventors: Alex Aronov, Jon H. Come, Robert J. Davies, Albert Charles Pierce, Philip N. Collier, Ronald Lee Grey, Hardwin O'Dowd, James A. Henderson, Elaine B. Krueger, Anne-Laure Grillot, Arnaud Le Tiran, Yusheng Liao, David Messersmith, Jian Wang, Jingrong Cao, Upul Keerthi Bandarage, Suganthini S. Nanthakumar
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Patent number: 10118904Abstract: The invention relates to triazole compounds of formula I and I? or pharmaceutically acceptable salts thereof, useful as modulators of demyelinating diseases: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention, methods of using the compositions and kits thereof in the treatment of various demyelinating and neurodegenerative diseases, including multiple sclerosis.Type: GrantFiled: June 3, 2016Date of Patent: November 6, 2018Assignee: VERTEX PHARMACEUTICALS INCORPORATEDInventors: Robert J. Davies, Jingrong Cao, Meghan Elise Cockerill, Philip Noel Collier, Elisabeth Doyle, James Daniel Frantz, Huai Gao, Brian Anthony Goldman, Ronald Lee Grey, Jr., Anne-Laure Grillot, Wenxin Gu, James A. Henderson, Raul Eduardo Krauss Irarrazaval, Adrianne Lynn Kolpak, Yusheng Liao, Sanjay Shivayogi Magavi, David Messersmith, Albert Charles Pierce, Emanuele Perola, Elizabeth Jin-Sun Ryu, Joshua Syken, Jian Wang, Michael Paul DeNinno, Francois Maltais
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Publication number: 20170260175Abstract: The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3K?. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.Type: ApplicationFiled: May 23, 2017Publication date: September 14, 2017Inventors: Alex Aronov, Jon H. Come, Robert J. Davies, Albert Charles Pierce, Philip N. Collier, Ronald Lee Grey, Hardwin O'Dowd, James A. Henderson, Elaine B. Krueger, Anne-Laure Grillot, Arnaud Le Tiran, Yusheng Liao, David Messersmith, Jian Wang, Jingrong Cao, Upul Keerthi Bandarage, Suganthini S. Nanthakumar
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Patent number: 9685898Abstract: An apparatus includes a switch module that selectively turns on a switch to connect an input power conductor connected to a voltage source to a motor in a sequence. The switch for each phase is turned on for a portion of a cycle of a fundamental frequency of the voltage source. A source phase module determines a phase of the AC voltage source, a back-EMF phase module determines a phase of a back-EMF of the motor, and a torque module determines when a phase difference between the phase of the AC voltage source and the phase of the back-EMF is within a phase range indicative of a positive motor torque. A pulse module enables the switches in response to the phase difference having a phase within the phase range and disables the switches in response to the phase difference having a phase not in the phase range.Type: GrantFiled: July 1, 2014Date of Patent: June 20, 2017Assignee: ROCKWELL AUTOMATION TECHNOLOGIES, INC.Inventors: Kun Wei, HaiHui Lu, Andrew Jaap, David Messersmith, Randall Langer, Ping Lee
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Patent number: 9676759Abstract: The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3K?. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.Type: GrantFiled: May 7, 2013Date of Patent: June 13, 2017Assignee: Vertex Pharmaceuticals IncorporatedInventors: Alex Aronov, Jon H. Come, Robert J. Davies, Albert Charles Pierce, Philip N. Collier, Ronald Lee Grey, Hardwin O'Dowd, James A. Henderson, Elaine B. Krueger, Anne-Laure Grillot, Arnaud Le Tiran, Yusheng Liao, David Messersmith, Jian Wang, Jingrong Cao, Upul Keerthi Bandarage, Suganthini S. Nanthakumar
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Patent number: 9518570Abstract: A motor controller includes a motor winding heater function. The motor controller applies a predefined current to one or more of the motor windings without the use of additional dedicated motor winding heater devices. The motor controller serves to control the operation of the motor, while the motor windings serve both as a heater at times and to produce torque at times.Type: GrantFiled: April 12, 2012Date of Patent: December 13, 2016Assignee: Rockwell Automation Technologies, Inc.Inventors: David Messersmith, Andrew Jaap
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Publication number: 20160355488Abstract: The invention relates to triazole compounds of formula I and I? or pharmaceutically acceptable salts thereof, useful as modulators of demyelinating diseases: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention, methods of using the compositions and kits thereof in the treatment of various demyelinating and neurodegenerative diseases, including multiple sclerosis.Type: ApplicationFiled: June 3, 2016Publication date: December 8, 2016Inventors: Robert J. Davies, Jingrong Cao, Meghan Elise Cockerill, Philip Noel Collier, Elisabeth Doyle, James Daniel Frantz, Huai Gao, Brian Anthony Goldman, Ronald Lee Grey, Jr., Anne-Laure Grillot, Wenxin Gu, James A. Henderson, Raul Eduardo Krauss Irarrazaval, Adrianne Lynn Kolpak, Yusheng Liao, Sanjay Shivayogi Magavi, David Messersmith, Albert Charles Pierce, Emanuele Perola, Elizabeth Jin-Sun Ryu, Joshua Syken, Jian Wang, Michael Paul DeNinno, Francois Maltais
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Patent number: 9350275Abstract: An apparatus for a quasi variable frequency motor controller is includes a DFC module that applies a first frequency to a motor as part of a discrete frequency control (“DFC”) method for motor starting. The first frequency includes a discrete frequency in a plurality of discrete frequencies of the DFC method and each discrete frequency includes a frequency lower than a fundamental frequency of an alternating current (“AC”) voltage source providing power to the motor. The apparatus includes a torque module that determines when motor torque generated by the motor reaches a negative torque threshold and a next frequency module that applies a second frequency to the motor in response to the torque module determining that the motor torque has reached the negative torque threshold. The second frequency is a next frequency in the DFC method.Type: GrantFiled: July 1, 2014Date of Patent: May 24, 2016Assignee: ROCKWELL AUTOMATION TECHNOLOGIES, INC.Inventors: Kun Wei, HaiHui Lu, Andrew Jaap, David Messersmith, Randall Langer, Ping Lee
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Publication number: 20150333685Abstract: An apparatus includes a switch module that selectively turns on a switch to connect an input power conductor connected to a voltage source to a motor in a sequence. The switch for each phase is turned on for a portion of a cycle of a fundamental frequency of the voltage source. A source phase module determines a phase of the AC voltage source, a back-EMF phase module determines a phase of a back-EMF of the motor, and a torque module determines when a phase difference between the phase of the AC voltage source and the phase of the back-EMF is within a phase range indicative of a positive motor torque. A pulse module enables the switches in response to the phase difference having a phase within the phase range and disables the switches in response to the phase difference having a phase not in the phase range.Type: ApplicationFiled: July 1, 2014Publication date: November 19, 2015Inventors: Kun Wei, HaiHui Lu, Andrew Jaap, David Messersmith, Randall Langer, Ping Lee
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Publication number: 20150333663Abstract: An apparatus for a quasi variable frequency motor controller is includes a DFC module that applies a first frequency to a motor as part of a discrete frequency control (“DFC”) method for motor starting. The first frequency includes a discrete frequency in a plurality of discrete frequencies of the DFC method and each discrete frequency includes a frequency lower than a fundamental frequency of an alternating current (“AC”) voltage source providing power to the motor. The apparatus includes a torque module that determines when motor torque generated by the motor reaches a negative torque threshold and a next frequency module that applies a second frequency to the motor in response to the torque module determining that the motor torque has reached the negative torque threshold. The second frequency is a next frequency in the DFC method.Type: ApplicationFiled: July 1, 2014Publication date: November 19, 2015Inventors: Kun Wei, HaiHui Lu, Andrew Jaap, David Messersmith, Randall Langer, Ping Lee
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Publication number: 20150265635Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.Type: ApplicationFiled: June 5, 2015Publication date: September 24, 2015Applicant: PARATEK PHARMACEUTICALS, INC.Inventors: Peter Viski, Beena Bhatia, Tadeusz Warchol, David Messersmith
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Patent number: 9090541Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.Type: GrantFiled: July 12, 2012Date of Patent: July 28, 2015Assignee: Paratek Pharmaceuticals, Inc.Inventors: Peter Viski, Beena Bhatia, Tadeusz Warchol, David Messersmith
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Patent number: 8937064Abstract: The present invention relates to compounds of formula (I) useful as selective inhibitors of JAK2 kinase. The invention also provides pharmaceutical acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various diseases, conditions or disorders. The invention also provides processes for preparing the compounds of the invention.Type: GrantFiled: June 17, 2010Date of Patent: January 20, 2015Assignee: Vertex Pharmaceuticals IncorporatedInventors: Mark Ledeboer, Valerie Marone, Michelle Stewart, David Messersmith, John Duffy, Gabriel Martinez Botella, Jon Come, Huai Gao, Albert Pierce, Francesco Salituro
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Publication number: 20140315931Abstract: The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.Type: ApplicationFiled: April 11, 2014Publication date: October 23, 2014Applicant: Vertex Pharmaceuticals IncorporatedInventors: Mark Ledeboer, David Messersmith, Francois Maltais, Huai Gao, Tiansheng Wang, Jingrong Cao, John Duffy, Gabriel Martinez-Botella, Cornelia Forster, Marion Wannamaker, Francesco Salituro, Albert Pierce, Luc Farmer, Valerie Marone
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Publication number: 20140171454Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.Type: ApplicationFiled: December 10, 2013Publication date: June 19, 2014Applicant: Vertex Pharmaceuticals IncorporatedInventors: Mark Ledeboer, Albert Pierce, Guy Bemis, Luc Farmer, Tiansheng Wang, David Messersmith, John Duffy, Francesco Salituro, Jian Wang
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Patent number: 8741912Abstract: The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.Type: GrantFiled: April 5, 2007Date of Patent: June 3, 2014Assignee: Vertex Pharmaceuticals IncorporatedInventors: Mark Ledeboer, David Messersmith, Francois Maltais, Huai Gao, Tiansheng Wang, Jingrong Cao, John Duffy, Gabriel Martinez-Botella, Cornelia Forster, Marion Wannamaker, Francesco Salituro, Albert Pierce, Luc Farmer, Valerie Marone
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Publication number: 20140038936Abstract: The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3K?. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.Type: ApplicationFiled: May 7, 2013Publication date: February 6, 2014Inventors: Alex Aronov, Jon H. Come, Robert J. Davies, Albert Charles Pierce, Philip N. Collier, Ronald Lee Grey, Hardwin O'Dowd, James A. Henderson, Elaine B. Krueger, Anne-Laure Grillot, Arnaud Le Tiran, Yusheng Liao, David Messersmith, Jian Wang, Jingrong Cao, Upul Keerthi Bandarage, Suganthini S. Nanthakumar